Accent on Teaching Materials

This department includes the two sections New Developments in Statistical Computing and Statistical Computing Software Reviews; suitable contents for each of these sections are described under the respective section heading. Articles submitted for the department, outside the two sections, should not be highly technical and should be relevant to the teaching or practice of statistical computing.

An unbiased estimator of e is used to motivate a simple simulation exercise that requires only observations from the distribution uniform on (0, 1). Antithetic variables are introduced and applied to the simulation problem to give a second unbiased estimator of e with reduced variance.     

Detection and Interpretation of a Multivariate Signal Using Combined Charts

A control procedure is presented in this article that is based on jointly using two separate control statistics in the detection and interpretation of signals in a multivariate normal process. The procedure detects the following three situations: (i) a mean vector shift without a shift in the covariance matrix; (ii) a shift in process variation (covariance matrix) without a mean vector shift; and (iii) both a simultaneous shift in the mean vector and covariance matrix as the result of a change in the parameters of some key process variables. It is shown that, following the occurrence of a signal on either of the separate control charts, the values from both of the corresponding signaling statistics can be decomposed into interpretable elements. Viewing the two decompositions together helps one to specifically identify the individual components and associated variables that are being affected. These components may include individual means or variances of the process variables as well as the correlations between or among variables. An industrial data set is used to illustrate the procedure.     

An improved comorbidity summary score for measuring disease burden and predicting mortality with applications to two national cohorts

Abstract

Research involving administrative healthcare data to study patient outcomes requires the investigator to account for the patient’s disease burden in order to reduce the potential for biased results. Here we develop a comorbidity summary score based on variable importance measures derived from several statistical and machine learning methods and show it has superior predictive performance to the Elixhauser and Charlson indices when used to predict 1-year, 5-year, and 10-year mortality. We used two large Veterans Administration cohorts to develop and validate the summary score and compared predictive performance using the area under ROC curve (AUC) and the Brier score.     

A new approximation to the distribution function of the studentized maximum root

The Studentized maximum root (SMR) distribution is useful for constructing simultaneous confidence intervals around product interaction contrasts in replicated two-way ANOVA. A three-moment approximation to the SMR distribution is proposed. The approximation requires the first three moments of the maximum root of a central Wishart matrix. These values are obtained by means of numerical integration. The accuracy of the approximation is compared to the accuracy of a two-moment approximation for selected two-way table sizes. Both approximations are reasonably accurate. The three-moment approximation is generally superior.     

A generating algorithm for linear trend-free and nearly linear trend-free block designs

The theory and properties of trend-free (TF) and nearly trend-free (NTF) block designs are wel1 developed. Applications have been hampered because a methodology for design construction has not been available.

This article begins with a short review of concepts and properties of TF and NTF block designs. The major contribution is provision of an algorithm for the construction of linear and nearly linear TF block designs. The algorithm is incorporated in a computer program in FORTRAN 77 provided in an appendix for the IBM PC or compatible microcomputer, a program adaptable also to other computers. Three sets of block designs generated by the program are given as examples.

A numerical example of analysis of a linear trend-free balanced incomplete block design is provided.     

Ridge Regression: Degrees of Freedom in the Analysis of Variance

It appears to be common practice with ridge regression to obtain a decomposition of the total sum of squares, and assign degrees of freedom, according to established least squares theory. This discussion notes the obvious fallacies of such an approach, and introduces a decomposition based on orthogonality, and degrees of freedom based on expected mean squares, for non-stochastic k.     

Response transformations in repeated measures and growth curve models

This article describes estimation and inference procedures for the parameters of the Box-Cox and foided-power transformations in repeated measures and growth curve models. Procedures for computing maximum likelihood estimates of the transformation and covariance parameters under several covanance structures (omnibus sphericity, local sphericity, and unstructured) are described. Lack of fit statistics and hypothesis tests for comparing these structures also are described. The procedures are illustrated on three data sets. Software for performing the analyses in the SAS System is described and is available from the authors.     

Maximum likelihood ridge displays

I illustrate likelihood methods for estimating the consequences of shrinkage along any ridge path as well as methods for picking a two-hyperparameter path of optimal curvature and the optimal point on that path. In addition to my published "classical" methods, I also illustrate both the empirical Bayes and the random coefficient maximum likelihood approaches. Traces of risks for known parameters and losses for simulated responses are followed by traces of estimates that can reveal the same general information.