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1.
Stephen J. Ruberg Frank E. Harrell Jr. Margaret Gamalo-Siebers Lisa LaVange J. Jack Lee Karen Price 《The American statistician》2019,73(1):319-327
ABSTRACTThe cost and time of pharmaceutical drug development continue to grow at rates that many say are unsustainable. These trends have enormous impact on what treatments get to patients, when they get them and how they are used. The statistical framework for supporting decisions in regulated clinical development of new medicines has followed a traditional path of frequentist methodology. Trials using hypothesis tests of “no treatment effect” are done routinely, and the p-value < 0.05 is often the determinant of what constitutes a “successful” trial. Many drugs fail in clinical development, adding to the cost of new medicines, and some evidence points blame at the deficiencies of the frequentist paradigm. An unknown number effective medicines may have been abandoned because trials were declared “unsuccessful” due to a p-value exceeding 0.05. Recently, the Bayesian paradigm has shown utility in the clinical drug development process for its probability-based inference. We argue for a Bayesian approach that employs data from other trials as a “prior” for Phase 3 trials so that synthesized evidence across trials can be utilized to compute probability statements that are valuable for understanding the magnitude of treatment effect. Such a Bayesian paradigm provides a promising framework for improving statistical inference and regulatory decision making. 相似文献
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Tracy AJ Erkut S 《Sociological perspectives : SP : official publication of the Pacific Sociological Association》2002,45(4):445-466
Athletics is the most prominent extracurricular activity in U.S. secondary schools in terms of student participation and school budgets. The latter is often justified on the grounds that healthy bodies produce healthy minds, that school sports boost school spirit, and that participation in school-based sports increases students' self-esteem. In this article we examine the interrelationships among participation in a school-based sport and the benefits assumed to be associated with it. Specifically, we test a model that postulates that school spirit, operationalized as attachment to school, and healthy bodies, operationalized as a sense of physical well-being, mediate the relationship between school sports and self-esteem. Data from the National Longitudinal Study of Adolescent Health on Caucasian and African American girls and boys were employed to test the model. School attachment and physical well-being absorbed the statistical effect of participating in a sport for all four gender-by-race groups. Among Caucasian girls a negative residual effect of sports participation was observed, which suggests that sports participation encapsulates multiple effects with contradictory influences. For African American girls school attachment by itself was not a significant mediator of the effect of sports participation on self-esteem. For all groups a sense of physical well-being was the more powerful mediator. 相似文献
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In light of use by airline unions of partial-strike tactics, such as concerted refusals to bid for overtime work and so-called
” CHAOS” tactics involving unannounced refusals to fly after passengers have been ticketed and are ready to board, the authors
examine whether the Railway Labor Act (RLA) should be interpreted to permit employers to discipline employees for engaging
in such tactics, or whether these are a protected form of economic pressure. Although in many respects bargaining duties and
economic weapons under the RLA are read consonant with precedents under the National Labor Relations Act (NLRA) (which governs
all industries other than rail and air transport), there are a few decisions suggesting that during the period when self-help
may be resorted to, employees can engage in partial strike activities as long as they violate no court order but are subject
to permanent replacement in limited circumstances. These decisions, the authors submit, fail to take account of Supreme Court
decsions since the 1930s that some economic pressures by unions, such as slowdowns and sitins, may not violate the labor laws
but nor are they protected by those laws so as to immunize partial strikers from employer discipline. These decisions are
not based on unique features of the NLRA. Rather, they give recognition to the background assumptions of Congress that employers
may act to protect their property interests as long as they do not run afoul of NLRA or RLA protections and that employees
who engage in partial-strike activities are subject to employer discipline even where not strictly necessary to maintain operations.
Moreover, these tactics skew the bargaining process by giving employees an essentially risk-free gambit to pressure their
economic position through planned disruption of carrier operations.
Professor Estreicher is also labor and employment counsel to O’Melveny & Myers, LLP. The views expressed herein are the authors’
and should not be attributed to any organization. Hannah Breshin and Tom Jerman of O’Melveny & Myers, assisted the authors
with this article. We also thank Professor Herbert Northrup for his helpful comments. 相似文献
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Concurrent and longitudinal associations between peer crowd affiliation and internalized distress were examined in a sample of 246 youth (148 girls, 98 boys). Children completed measures of depression, social anxiety, loneliness, and self‐esteem when they were in grades 4 to 6 (Time 1), and again 6 years later during adolescence (grades 10 – 12; Time 2). At Time 2, adolescents also reported their self‐concept and their identification with reputation‐based peer crowds, including Populars, Jocks, Brains, Burnouts, Non‐Conformists, and None/Average crowds. Results indicated that adolescents' report of peer crowd affiliation was concurrently associated with self‐concept and levels of internalizing distress. Follow‐back analyses of internalizing trajectories revealed that Populars/Jocks had experienced significant declines in internalizing distress across development, whereas Brains exhibited some increases in internalizing distress between childhood and adolescence. 相似文献
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Peter Van Der Veer 《全球网;跨国事务杂志》2002,2(2):95-109
In this article I deal with transnational Hindu and Muslim movements. I reject the common assertion that migrant communities are conservative in religious and social matters by arguing that ‘traditionalism’ requires considerable ideological creativity and that this significantly transforms previous practices and discourses. I suggest that religious movements, active among migrants, develop cosmopolitan projects that can be viewed as alternatives to the cosmopolitanism of the European Enlightenment. This raises a number of challenges concerning citizenship, integration and political loyalty for governmentality in the nation‐states in which these cosmopolitan projects are carried out. I suggest that rather than looking at religious migrants as at best conservative and at worst terrorist one should perhaps pay some attention to the creative moments in human responses to new challenges and new environments. 相似文献