Publication bias and outcome reporting bias: agomelatine as a case example

Publication bias and outcome reporting bias contribute to distorted perceptions of drug efficacy and the underreporting of adverse events. To demonstrate these biases, this article describes how the clinical profile of the antidepressant agent agomelatine (Valdoxan(?)) has been presented in the literature. Agomelatine has been systematically assessed in 10 short-term placebo-controlled studies and three long-term placebo-controlled relapse prevention studies. Five published trials demonstrated clinically modest but statistically significant benefits over placebo. Five unpublished trials did not find agomelatine more effective than placebo, but in two of these studies the active comparison drug (fluoxetine [Prozac(?)] or paroxetine [Paxil(?)]) was more effective than placebo. Agomelatine was more effective than placebo in one of three relapse prevention studies, but only the positive study was published. Based on what is evident in the entire published and unpublished dataset, agomelatine does not have a tremendously superior sleep and sexual effects profile. The risk of liver toxicity is also not prominently highlighted in the published literature.     

The Value of Seeking Financial Advice

Retirement planning data gathered from an online survey at a large university in October 2009 are used to examine differences in a variety of retirement planning measures between people who have and have not met with a financial advisor. Problems of self-selection and endogeneity are addressed through the use of propensity scores. The study’s major finding is that working with an advisor is related to several important financial planning activities, including goal setting, calculation of retirement needs, retirement account diversification, use of supplemental retirement accounts, accumulation of emergency funds, positive behavioral responses to the recent economic crisis, and retirement confidence. Use of a financial advisor was not related to self-reported retirement savings or short-term growth in retirement account asset values.     

Sentencing outcomes of convicted child sex offenders

This research examines the sentencing outcomes of convicted child sexual offenders from data collected over an eight year period. Multiple regression and nominal log linear regression are used to examine length of prison sentence, length of probation sentence, and whether the convicted offender is actually sent to prison or to probation. While many independent variables appear to be related to sentence outcome, they fall into three categories: characteristics of the offender, characteristics of the victim, and characteristics of the crime. Additionally, while many variables appear related at the bivariate level, when multivariate analysis is applied, fewer variables remain significant, and these are mostly from the characteristics of the offense.     

Preventing impaired driving opportunities and problems

Impaired driving remains a significant public health problem in the United States. Although impressive reductions in alcohol-related fatalities occurred between 1982 and 1997, during which all 50 States enacted the basic impaired-driving laws, progress has stagnated over the last decade. Substantial changes in the laws and policies or funding for the enforcement of the criminal offense of driving while intoxicated (DWI) are needed for further substantial progress in reducing alcohol-related crash injuries. However, research indicates that evidence-based laws in the 50 States and current best practices in DWI enforcement are not being fully adopted or used. It seems, however, that effective operations, such as the low-staff check points that are routinely applied in many communities, could be extended to many more police departments. In addition, several enforcement methods have been proposed but never fully tested.     

Behavioural criteria of managerial and leadership effectiveness within Egyptian and British public sector hospitals: an empirical case study and multi-case/cross-nation comparative analysis

This paper reports the results of a study of managerial and leadership effectiveness carried out within an Egyptian public sector hospital in which concrete examples of ‘effective’ and ‘least effective/ineffective’ manager and managerial leader behaviour, as observed by superiors, peers and subordinates, were collected using the critical incident technique. These critical incidents were then content analyzed to identify a smaller number of discrete behavioural statements and criteria of effectiveness. The paper also reports the results of a subsequent comparative analysis of these Egyptian findings against equivalent behavioural criteria that emerged from studies in two different British NHS Trust hospitals. This latter multi-case/cross-nation study revealed high degrees of overlap, commonality, and relative generalization across all three organizations. The results lend strong empirical support to those who believe in ‘generic’ and ‘universalistic’ explanations of the nature of managerial and leadership effectiveness.     

Going global: professional mobility and concerns for LGBT workers

The world of work has regularized the practice of people moving from one country to another to accept job assignments. Travel and relocation are stress-laden endeavours. For LGBT people, the risks can be more complicated than they are for heterosexuals. This article explores particular challenges that LGBT people face when they travel and relocate for business, both domestically and internationally. The article is contextualized with a literature review on sexual minorities and workplace issues, and uses auto-ethnographic stories of three of the authors’ lived experiences as sexual minorities relocating for professional reasons in order to examine issues related to LGBT relocation. These issues include legal, social, cultural and familial considerations. Implications and suggestions for human resource developers are presented, which include acquiring awareness around the psychological and physiological reactions to new and diverse ecologies, or ‘eco-shocks’.     

The impact of international experience on cultural intelligence: an application of contact theory in a structured short-term programme

The objective of this study is to examine the impact of a short-term international experience, which is designed to address the conditions outlined in Allport’s (Allport, G.W. 1954. The Nature of Prejudice. New York: Perseus Book Group) contact hypothesis, on each of the four factors which make up cultural intelligence (CQ). A sample of 135 university students was broken up into test and control groups. The results for the test group suggest that the short-term experience ranging from 7 to 12 days within a structured study abroad service programme, including modest pre-trip preparation, found a significant increase in each of the four factors of CQ. At the same time, there was no significant change in the control group. Implications for human research development research and practice as well as limitations and suggested areas for future research are discussed.     

Note on inventory models with Weibull distribution deterioration

This article explores the inventory model with a general demand rate function in which both the Weibull distributed deterioration and partial backlogging are considered. The inventory model discussed here is based on the important finding by Wu [Wu, K.S., 2001. An EOQ inventory model for items with Weibull distribution deterioration, ramp type demand rate and partial backlogging. Production Planning and Control, 12, 787–793]. There are four parts in our research. First, we derive the analytical framework of the inventory model for a general demand rate function1 1.?Based on detailed suggestions of Professor Wafik H. Iskander, Email: whiskander@mail.wvu.edu . Second, for the ramp type demand, we improve Wu's model to find the criterion to guarantee the existence and uniqueness of the optimal solution. Third, we develop a new model to compensate for the missing case in Wu's article. Fourth, we combine our results to show that our findings are applicable to the ramp type demand inventory model, so that the optimal solution is independent of the demand function. Finally, some numerical examples and graphs are provided to illustrate our discovery and demonstrate the application of our analytical framework.     

Conceptualizing social-ecological drivers of change in urban forest patches

Urban Ecosystems - We introduce a conceptual model of the urban forest patch as a complex social-ecological system, incorporating cross-scale interactions. We developed this model through an...