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921.
Comparison of the Cancer Risk of Methylene Chloride Predicted from Animal Bioassay Data with the Epidemiologic Evidence 总被引:1,自引:0,他引:1
Linda Tollefson Ronald J. Lorentzen Robert N. Brown Janet A. Springer 《Risk analysis》1990,10(3):429-435
Methylene chloride has been shown to be a lung and liver carcinogen in the mouse; yet, the current epidemiologic data show no adverse health effects associated with chronic exposure to this compound. Hearne et al. have compared the results of a large mortality study on occupational exposure to methylene chloride to the human risk predictions based on the rodent bioassay to point out the inconsistency between the animal toxicologic and human epidemiologic data. The maximum number of lung and liver cancers predicted due to methylene chloride exposure based on the rodent bioassay data was 24 compared to 14 deaths from these cancers actually observed in the Hearne et al. epidemiology study. We assess the minimum risk detectable by the human study in order to calculate the upperbound potency of methylene chloride and compare it to the potency derived from the bioassay data. Results from the epidemiology study imply an upperbound potency of 1.5 x 10(-2) per ppm, compared to 1.4 x 10(-2) per ppm calculated using the most conservative analysis of the animal data. We conclude that the negative epidemiology study of Hearne et al. is not sufficiently powerful to show that the risk is inconsistent with the human risk estimated by modeling the rodent bioassay data. Specifically, the doses to which the workers were exposed, the population studied, and the latency period were not adequate to determine that the risks are outside the bounds of the risk estimates predicted by low-dose modeling of the animal data. 相似文献
922.
Margaret Lloyd Michael Preston-Shoot Bogusia Temple With Robert Wuu 《Disability & Society》1996,11(3):301-316
The NHS and Community Care Act 1990 (NHSCCA) requires that local authorities should consult with service users in their review and planning of services. This requirement is open to various levels of interpretation. The exercise becomes more complex when planning and review are based on a funded research project, in which the voice of users can easily be lost or their participation only nominal. This article examines some of the key issues and dilemmas in partnership research, through critical evaluation of a research project in which the authors were involved. Paradoxically, it is issues of power, control, expertise, authority and accountability which emerge as recurrent themes in examination of the practice of partnership. 相似文献
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Robert Platt 《The Sociological review》1989,37(4):636-667
The paper examines, and seeks to develop, the sociological concept of reflexivity. It identifies two senses of reflexivity, one associated with ethnomethodological accounts of members’practical reasoning, the other with a more philosophical sense of conscious self-referencing, and analyses their relationship. The paper argues that the development of this form of analysis leads to a form of propositional undecidability which makes it typically ‘postmodern’. The development is linked to ideas of recursion, as these are expounded in computer science and mathematics, and to Derrida's interpretation of ‘textual fold’— this also being used to ground the association of reflexivity with postmodernism. The analysis ‘returns to the social’by considering aspects of Niklas Luhmann's explication of social reflexivity. It concludes by examining the understanding that a postmodern sociology might have of a postmodern society in which the grounds for social order have become undecidable. 相似文献
927.
Robert E. Frederick Ph.D. W. Michael Hoffman Ph.D. 《International Journal of Value-Based Management》1989,2(1):19-29
An analysis of the place of Business Ethics in the curriculum. 相似文献
928.
Workplace exposures to airborne chemicals are regulated in the U.S. by the Occupational Safety and Health Administration (OSHA) via the promulgation of permissible exposure limits (PELs). These limits, usually defined as eight-hour time-weighted average values, are enforced as concentrations never to be exceeded. In the case of chronic or delayed toxicants, the PEL is determined from epidemiological evidence and/or quantitative risk assessments based on long-term mean exposures or, equivalently, cumulative lifetime exposures. A statistical model was used to investigate the relation between the compliance strategy, the PEL as a limit never to be exceeded, and the health risk as measured by the probability that an individual's long-term mean exposure concentration is above the PEL. The model incorporates within-worker and between-worker variability in exposure, and assumes the relevant distributions to be log-normal. When data are inadequate to estimate the parameters of the full model, as it is in compliance inspections, it is argued that the probability of a random measurement being above the PEL must be regarded as a lower bound on the probability that a randomly selected worker's long-term mean exposure concentration will exceed the PEL. It is concluded that OSHA's compliance strategy is a reasonable, as well as a practical, means of limiting health risk for chronic or delayed toxicants. 相似文献
929.
This article shows that in Nepal breastfeeding almost completely explains the effects of following birth interval on childhood mortality during the first 18 months of age and partially explains the effect of following birth interval on childhood mortality between 18 and 60 months of age. Breastfeeding does not explain the effect of preceding birth interval on childhood mortality. The analysis is based on application of hazard models to data from the 1976 Nepal Fertility Survey. 相似文献
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