Off-label medication use

Prescribing medications for off-label uses is not illegal. Off-label prescribing includes using medications for unapproved indications; using a drug outside of the recommended dosage range or duration of use; using a drug in certain unapproved patient populations, such as those defined by age, sex, or particular clinical parameters; or intentionally using a medication in a patient who has a known contraindication. Medications would be considered appropriate for off-label use based on their known clinical pharmacology, evidence from clinical studies, and sometimes from the personal experience of the prescriber. The decision to use a drug off label should be based on a careful assessment of the patient's treatment history and the drug's potential risks and benefits. Patients should be given adequate informed consent about how the drug is being used off label and why, along with appropriate information about known risks and side effects.     

Patterns of intimate partner violence in young adult couples: nonviolent, unilaterally violent, and mutually violent couples

This study examined nonviolent (NV), unilaterally violent (UV), and mutually violent (MV) patterns of perpetrated intimate partner violence in relation to dyadic relationship quality and partner injury. The respondents were 1,294 young adult, Add Health partners (AHP) and their non-Add Health partners (NAHP), in dating, engaged, or in marital relationships, who were participants in Wave III of the National Longitudinal Study of Adolescent Health (Add Health). Using both partner reports of perpetration to classify intimate partner violence (IPV) patterns resulted in 25% of couples with a MV pattern, and 75% of couples with a UV pattern; among those couples (41%) reporting any perpetrated IPV. Results also showed poorer relationship quality and higher partner sensation-seeking scores among MV and UV couples when contrasted with NV couples. Those couples with MV patterns were more likely to contain partner injury than those with UV patterns.     

Links between childhood physical abuse and intimate partner aggression: the mediating role of anger expression

Research linking childhood physical abuse (CPA) and adult intimate partner aggression (IPA) has focused on individuals without sufficient attention to couple processes. In this study, 109 couples reported on histories of CPA, IPA, and anger expression. Actor-partner interdependence model (APIM) was used to examine links between CPA and revictimization and perpetration of IPA, with anger suppression as a potential mediator. Women's CPA histories were associated with more physical aggression towards and more revictimization by partners. Men's CPA histories were only associated at the trend level with their revictimization. Anger suppression fully mediated the link between women's CPA and both revictimization and perpetration of IPA. Findings suggest that women with CPA histories are more prone to suppress anger, which leaves them at greater risk for revictimization and perpetration of IPA.     

Mentoring Siblings of Gang Members: A Template for Reaching Families of Gang Members?

Mentoring has become a popular model of intervention to reduce the risk of offending, and has been proposed as an effective tool to tackle the risk of gang membership. This paper reviews the existing literature on mentoring and reports on a qualitative evaluation of a mentoring programme targeted at young people ‘at risk’ of gang membership in an English city. The study highlights important issues around these interventions. Although we found it a useful way to engage otherwise hard‐to‐reach families, important limitations remain: their potential labelling impact and their limited impact in isolation from other more ambitious measures.     

Movement-in-depth, cognitive impairment, and crash risk

In this study, 243 cognitively intact and cognitively impaired older participants' movement-in-depth (looming) abilities were assessed using a portable device that we had previously developed in our laboratory. Results indicated normative relationships between looming ability and age, looming ability and driving violation records, and age and driving violation records. Findings also confirmed the validity and reliability of the measurements taken with the device. In conclusion, this device may be useful for identifying drivers at risk for rear-end collisions, developing effective training interventions, and creating fair and valid driver licensing tests.     

Review of walking hazards for railroad workers

This is a review of walking tasks in the railroad environment, and the injuries that result from slips, trips, falls, or other acute or even non-traumatic exposures. The lack of federal regulations for railroad walkways has led several states to develop and enforce their own regulations. Support from the research literature for such regulations has come from biomechanical studies of the effects of walking on railroad ballast, which will be reviewed.     

Expressing Gambling-Related Cognitive Biases in Motor Behaviour: Rolling Dice to Win Prizes

Cognitive perspectives on gambling propose that biased thinking plays a significant role in sustaining gambling participation and, in vulnerable individuals, gambling problems. One prominent set of cognitive biases include illusions of control involving beliefs that it is possible to influence random gaming events. Sociologists have reported that (some) gamblers believe that it is possible to throw dice in different ways to achieve gaming outcomes (e.g., ‘dice-setting’ in craps). However, experimental demonstrations of these phenomena are lacking. Here, we asked regular gamblers to roll a computer-simulated, but fair, 6 sided die for monetary prizes. Gamblers allowed the die to roll for longer when attempting to win higher value bets, and when attempting to hit high winning numbers. This behaviour was exaggerated in gamblers motivated to keep gambling following the experience of almost-winning in gambling games. These results suggest that gambling cognitive biases find expression in the motor behaviour of rolling dice for monetary prizes, possibly reflecting embodied substrates.     

Gender identity and lexical variation in social media

We present a study of the relationship between gender, linguistic style, and social networks, using a novel corpus of 14,000 Twitter users. Prior quantitative work on gender often treats this social variable as a female/male binary; we argue for a more nuanced approach. By clustering Twitter users, we find a natural decomposition of the dataset into various styles and topical interests. Many clusters have strong gender orientations, but their use of linguistic resources sometimes directly conflicts with the population‐level language statistics. We view these clusters as a more accurate reflection of the multifaceted nature of gendered language styles. Previous corpus‐based work has also had little to say about individuals whose linguistic styles defy population‐level gender patterns. To identify such individuals, we train a statistical classifier, and measure the classifier confidence for each individual in the dataset. Examining individuals whose language does not match the classifier's model for their gender, we find that they have social networks that include significantly fewer same‐gender social connections and that, in general, social network homophily is correlated with the use of same‐gender language markers. Pairing computational methods and social theory thus offers a new perspective on how gender emerges as individuals position themselves relative to audiences, topics, and mainstream gender norms.     

Globalization and Collective Labor Rights

The impact of globalization has been a perennial source of contention, and issues regarding labor rights have been a visible aspect of this struggle. Despite the popular controversy about a potential “race to the bottom” regarding globalization and labor rights, the empirical record on these linkages remains mixed. Moreover, despite the multifaceted nature of globalization, extant literature in this area has focused purely on several specific facets of economic globalization, such as trade and FDI. We focus on two additional aspects of globalization, social and political integration, as well as a broadly based measure of economic globalization, and examine how they influence collective labor rights—both in terms of labor laws, as well as their enforcement in practice—in the developing world from 1986 to 2002. We find that all three facets of globalization are negatively related to labor rights. Specifically, social, political, and economic globalization are related to the decoupling of labor practices from extant labor laws; that is, labor practices deteriorate while labor laws remain largely unaffected.     

Does media coverage influence public attitudes towards welfare recipients? The impact of the 2011 English riots

Following the shooting of Mark Duggan by police on 4 August 2011, there were riots in many large cities in the UK. As the rioting was widely perceived to be perpetrated by the urban poor, links were quickly made with Britain's welfare policies. In this paper, we examine whether the riots, and the subsequent media coverage, influenced attitudes toward welfare recipients. Using the British Social Attitudes survey, we use multivariate difference‐in‐differences regression models to compare attitudes toward welfare recipients among those interviewed before (pre‐intervention: i.e. prior to 6 August) and after (post‐intervention: 10 August–10 September) the riots occurred (N = 3,311). We use variation in exposure to the media coverage to test theories of media persuasion in the context of attitudes toward welfare recipients. Before the riots, there were no significant differences between newspaper readers and non‐readers in their attitudes towards welfare recipients. However, after the riots, attitudes diverged. Newspaper readers became more likely than non‐readers to believe that those on welfare did not really deserve help, that the unemployed could find a job if they wanted to and that those on the dole were being dishonest in claiming benefits. Although the divergence was clearest between right‐leaning newspaper and non‐newspaper readers, we do not a find statistically significant difference between right‐ and left‐leaning newspapers. These results suggest that media coverage of the riots influenced attitudes towards welfare recipients; specifically, newspaper coverage of the riots increased the likelihood that readers of the print media expressed negative attitudes towards welfare recipients when compared with the rest of the population.