A class of bivariate regression models for discrete and/or continuous responses

ABSTRACT

A general class of models for discrete and/or continuous responses is proposed in which joint distributions are constructed via the conditional approach. It is assumed that the distributions of one response and of the other response given the first one belong to exponential family of distributions. Furthermore, the marginal means are related to the covariates by link functions and a dependency structure between the responses is inserted into the model. Estimation methods, diagnostic analysis and a simulation study considering a Bernoulli-exponential model, a particular case of the class, are presented. Finally, this model is used in a real data set.     

Spatial Matching of Multiple Configurations of Points with a Bioinformatics Application

In this article, we present a general model to deal with the problem of matching multiple objects or configurations of points from a Bayesian point of view. We study both labeled and non labeled cases. Our model generalizes, in terms of non singular affine transformations and multiple configurations, previous two-terms matching models. As a practical application in Bioinformatics, we consider data from a microarray experiment of gorilla, bonobo, and human-cultured fibroblasts. We find out the matchings and the best affine transformation between the projections of genes on a two-dimensional space, obtained by a multidimensional scaling technique.     

A Matrix Variate Closed Skew-Normal Distribution with Applications to Stochastic Frontier Analysis

In this article, we introduce the matrix extension of the closed skew-normal distribution and give two constructions for it: a marginal one and another based on hidden truncation. Important basic properties of the distribution are presented such as its closure under linear transformation and moment generating function. We also give distributional results for quadratic forms involving random matrices distributed according to two particular cases of it. Using an additive construction, we derive a submodel which can be employed to describe the compound error structure of a very general multivariate stochastic frontier model. Finally, we consider the skew-elliptical extension of the proposed distribution.     

Likelihood-Based Inference for Multivariate Skew-Normal Regression Models

In this article, we present EM algorithms for performing maximum likelihood estimation for three multivariate skew-normal regression models of considerable practical interest. We also consider the restricted estimation of the parameters of certain important special cases of two models. The methodology developed is applied in the analysis of longitudinal data on dental plaque and cholesterol levels.     

Strong consistency of presmoothed Kaplan–Meier integrals when covariables are present

It is known that the Kaplan–Meier estimation may be improved via presmoothing methods. In this article, we introduce an extended presmoothed Kaplan–Meier estimator in the presence of covariates. The main result is the strong consistency of general empirical integrals based on such an estimator. As applications, one can obtain a consis-tent multivariate empirical distribution under censoring, and also can obtain a consistent estimation of regression parameters. We illustrate the new estimation methods through simulations and real data analysis.     

Convergence of non-linear functionals of smoothed empirical processes and kernel density estimates

We consider regularizations by convolution of the empirical process and study the asymptotic behaviour of non-linear functionals of this process. Using a result for the same type of non-linear functionals of the Brownian bridge, shown in a previous paper [4], and a strong approximation theorem, we prove several results for the p-deviation in estimation of the derivatives of the density. We also study the asymptotic behaviour of the number of crossings of the smoothed empirical process defined by Yukich [17] and of a modified version of the Kullback deviation.     

On asymptotic posterior normality for controlled branching processes

For a controlled branching process (CBP) with offspring distribution belonging to the power series family, the asymptotic normality of the posterior distribution of the basic parameter and the offspring mean is proved. As practical applications, we calculate asymptotic high probability density credibility sets for the offspring mean and we provide a rule to make inference about the value of this parameter. Moreover, the asymptotic posterior normality of the respective parameters of two classical branching models, namely the standard Galton–Watson process and the Galton–Watson process with immigration, is derived as particular cases of the CBP.     

Bayesian factor models in characterizing molecular adaptation

Assessing the selective influence of amino acid properties is important in understanding evolution at the molecular level. A collection of methods and models has been developed in recent years to determine if amino acid sites in a given DNA sequence alignment display substitutions that are altering or conserving a prespecified set of amino acid properties. Residues showing an elevated number of substitutions that favorably alter a physicochemical property are considered targets of positive natural selection. Such approaches usually perform independent analyses for each amino acid property under consideration, without taking into account the fact that some of the properties may be highly correlated. We propose a Bayesian hierarchical regression model with latent factor structure that allows us to determine which sites display substitutions that conserve or radically change a set of amino acid properties, while accounting for the correlation structure that may be present across such properties. We illustrate our approach by analyzing simulated data sets and an alignment of lysin sperm DNA.     

On time-irreversibility and other non-linear features in time series

Time-irreversibility, asymmetry of the distribution, and the occurrence of sudden bursts are considered, amongst others, as non-linear features in time series modeling. The implication is often made that time series showing these features must be analyzed using non-linear models. In contrast, this paper shows that time-irreversible asymmetric time series showing certain types of sudden bursts may be generated by linear models with adequate input sequences. Thus some non-linear time series features may be caused by the pattern in the input sequence rather than by non-linearity in the model. Examples are considered to illustrate the situation.     

Heterogeneous data modeling with two-component Weibull–Poisson distribution

The mixture distribution models are more useful than pure distributions in modeling of heterogeneous data sets. The aim of this paper is to propose mixture of Weibull–Poisson (WP) distributions to model heterogeneous data sets for the first time. So, a powerful alternative mixture distribution is created for modeling of the heterogeneous data sets. In the study, many features of the proposed mixture of WP distributions are examined. Also, the expectation maximization (EM) algorithm is used to determine the maximum-likelihood estimates of the parameters, and the simulation study is conducted for evaluating the performance of the proposed EM scheme. Applications for two real heterogeneous data sets are given to show the flexibility and potentiality of the new mixture distribution.