Titin--springing back to youth?

Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive elasticity on the cardiomyocyte. Several titin isoforms exist, and they display varying size and degrees of elasticity. We review two interesting reports that show how variations in titin isoforms might be implicated in cardiac failure.     

Childhood behavioral and emotional disorders

We reviewed the literature on family treatment for childhood behavioral and emotional disorders and found an increase in the number of studies since 1995; however there was significant variation by disorder and therapy model. There is substantially more research on externalizing disorders (i.e., conduct disorder, attention deficit hyperactivity disorder, oppositional defiant disorder) then internalizing disorders, depression and anxiety disorders. The data support the conclusion that family-based interventions produce results comparable to individually oriented interventions, and in some cases family-based interventions are superior to individual treatments. To date, cognitive behavioral family therapy and parent management have been the two models studied, almost exclusively. Implications for family therapy and future research are considered.     

Estimating the Structure of Agricultural Investment: A Stochastic- Coefficients Approach

Two approaches, a flexibie-accelerator model and a stochastic-coefficients alternative, are used to estimate the structure of aggregate agricultural investment. Structural estimates of the adjustment rates for each model differ. The stochastic-coefficients model, however, performs better in out-of-sample forecasting.     

Diversity in sociology: Problem or solution?

Some of sociology’s recent internal critics (e.g., Turner and Turner, 1990; Halliday and Janowitz, 1992; Collins, 1986; Gans, 1990; Crane and Small, 1992) suggest that the discipline's diversity of theoretical, methodological and substantive foci leave it in a weakened position for achieving individual and collective ends. Other sociologists (e.g., D'Antonio, 1992; Roos and Jones, 1993; Stacey and Thorne, 1985) argue that substantive diversity has made the discipline attractive to a greater variety of previously underrepresented groups, particularly women, groups that have, in turn, contributed to sociology’s substantive diversity. This paper reports on a content analysis of 2,016 articles from North American sociology journals in 1936, 1956, 1976, and 1996 as well as from chemistry, anthropology, economics, political science, and psychology journals in 1996. The analysis focused on a number of, often contradictory, hypotheses drawn from the competing views of sociology's diversity with respect to its substantive concerns and its gender composition. It finds, for instance, that there is more substantive diversity in today's sociology journal articles than there was earlier, at least when diversity is measured in terms of fields that are reputed to be attractive to women. This may not be surprising, since more women are writing sociology journal articles than ever before. Moreover, the substantive diversity seems to be related to more, not less, funding of sociological research. It is, of course, a trite remark — one made more frequently by sociologists than by their gibing critics — that sociology has not yet come to the development which commands from its adherents wholehearted agreement as to the objectives to be aimed at, the field to he limited, and the methods to be used. Gladys Bryson, 1936     

Validation of a Multi‐Dimensional Measure of Strategy Development Processes

In this paper, we present evidence on the measurement properties of an instrument that assesses six dimensions of organizational strategy development. These dimensions are labelled planning, incrementalism, cultural, political, command and enforced choice. Using data from 5332 managers, results indicate the instrument has acceptable reliability and validity. Exploratory factor analysis confirms its underlying structure. Generally, the sub‐scales have acceptable internal reliability and inter‐rater reliability at the organizational level (n = 770 organizations). Further, using data aggregated at the organizational level, the sub‐scales are judged to have acceptable validity from the pattern of correlations amongst the six dimensions and with other variables.