Titin--springing back to youth?

Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive elasticity on the cardiomyocyte. Several titin isoforms exist, and they display varying size and degrees of elasticity. We review two interesting reports that show how variations in titin isoforms might be implicated in cardiac failure.     

True patient safety begins at the top. Leaders at one large health system rally around safety,avoid blame game

Making patient safety the No. 1 priority at a hospital or clinic sounds like a easy task. It isn't. At one Oklahoma health system, an improved patient safety program is a massive effort requiring input and participation from every member of the staff. Figuring out how to convince employees that patient safety is their first priority means developing an extensive communication and education program.     

The impact of childhood abuse and neglect on adult mental health: a prospective study

This paper examines the impact of three types of victimization in childhood--sexual abuse, physical abuse, and neglect--on lifetime measures of mental health among adults. In contrast to research that relies on retrospective recall of childhood victimization, this work uses a prospective sample gathered from records of documented court cases of childhood abuse and neglect in a midwestern city around 1970. These subjects were interviewed about twenty years later. In addition, this research compares outcomes of the 641 members of the abuse and neglect group with a matched control group of 510 persons who did not have documented cases of abuse or neglect. The results indicate that men who were abused and neglected as children have more dysthymia and antisocial personality disorder as adults than matched controls, but they did not have more alcohol problems. Abused and neglected women report more symptoms of dysthymia, antisocial personality disorder, and alcohol problems than controls. After controlling for stressful life events, however, childhood victimization had little direct impact on any lifetime mental health outcome. This research indicates the importance of adopting an approach that places childhood victimization in the context of other life stressors and of prospective changes over the life course.     

Assessing the impact of administrative policy on use of deadly force by on- and off-duty police

Deadly force research typically does not distinguish between shootings by on-duty and off-duty police. This article uses Philadelphia police shooting data from two time periods (1970-1978 and 1987-1992) and a unique quasi-experimental design to examine the comparative effects upon on- and off-duty police shootings of an administrative policy that limited police shooting discretion but that did not address questions of police weapons carrying and access to firearms. The article draws important distinctions between when to shoot and carry administrative policies and considers their impact on deadly force by on- and off-duty police.     

Who Reaps the Benefits,Who Bears the Risks? Comparative Optimism,Comparative Utility,and Regulatory Preferences for Mobile Phone Technology

Although the issue of risk target (e.g., self, others, children) is widely acknowledged in risk perception research, its importance appears underappreciated. To date, most research has been satisfied with demonstrating comparative optimism, i.e., lower perceived risk for the self than others, and exploring its moderators, such as perceived controllability and personal exposure. Much less research has investigated how the issue of target may affect benefit perceptions or key outcomes such as stated preferences for hazard regulation. The current research investigated these issues using data from a public survey of attitudes toward mobile phone technology (N= 1,320). First, results demonstrated comparative optimism for this hazard, and also found moderating effects of both controllability and personal exposure. Second, there was evidence of comparative utility, i.e., users believed that the benefits from mobile phone technology are greater for the self than others. Third, and most important for policy, preferences for handset regulation were best predicted by perceptions of the risks to others but perceived benefits for the self. Results suggest a closer awareness of target can improve prediction of stated preferences for hazard regulation and that it would be profitable for future research to pay more attention to the issue of target for both risk and benefit perceptions.     

Estimating the Structure of Agricultural Investment: A Stochastic- Coefficients Approach

Two approaches, a flexibie-accelerator model and a stochastic-coefficients alternative, are used to estimate the structure of aggregate agricultural investment. Structural estimates of the adjustment rates for each model differ. The stochastic-coefficients model, however, performs better in out-of-sample forecasting.     

Diversity in sociology: Problem or solution?

Some of sociology’s recent internal critics (e.g., Turner and Turner, 1990; Halliday and Janowitz, 1992; Collins, 1986; Gans, 1990; Crane and Small, 1992) suggest that the discipline's diversity of theoretical, methodological and substantive foci leave it in a weakened position for achieving individual and collective ends. Other sociologists (e.g., D'Antonio, 1992; Roos and Jones, 1993; Stacey and Thorne, 1985) argue that substantive diversity has made the discipline attractive to a greater variety of previously underrepresented groups, particularly women, groups that have, in turn, contributed to sociology’s substantive diversity. This paper reports on a content analysis of 2,016 articles from North American sociology journals in 1936, 1956, 1976, and 1996 as well as from chemistry, anthropology, economics, political science, and psychology journals in 1996. The analysis focused on a number of, often contradictory, hypotheses drawn from the competing views of sociology's diversity with respect to its substantive concerns and its gender composition. It finds, for instance, that there is more substantive diversity in today's sociology journal articles than there was earlier, at least when diversity is measured in terms of fields that are reputed to be attractive to women. This may not be surprising, since more women are writing sociology journal articles than ever before. Moreover, the substantive diversity seems to be related to more, not less, funding of sociological research. It is, of course, a trite remark — one made more frequently by sociologists than by their gibing critics — that sociology has not yet come to the development which commands from its adherents wholehearted agreement as to the objectives to be aimed at, the field to he limited, and the methods to be used. Gladys Bryson, 1936     

Children of Adolescent Mothers: Cognitive and Behavioral Status at Age Six

The cognitive and behavioral status at age six years of 185 children of adolescent mothers (60.5% boys) were assessed using the mother (CBCL) and teacher (TRF) report forms of the Child Behavior Checklist and the Bracken Basic Concepts Scale. There was evidence for impairment in all areas of functioning. More than half of the sample exceeded the borderline clinical cutoff (T = 60) on either the CBCL or TRF Total Problem score, and nearly half the sample had Bracken scores that were more than 1 SD below the normative mean. Only 26.9% of the children were in the normal range on all three measures. These results are discussed in terms of implications for social work practice with children and adolescent mother families.