Studies of resilience among youth experiencing homelessness: A systematic review

This article systematically reviews studies exploring resilience among youth experiencing homelessness. We searched eight databases, and 21 articles fit the inclusion criteria and represented four methodologies: qualitative (n = 7, 33.3%), survey and secondary data analysis (n = 8, 38.1%), quantitative (n = 4, 19.1%), and mixed-method (n = 2, 9.5%) designs. Studies indicate that youth experiencing homelessness rely on informal social networks for survival, and that spirituality, mental health, and creativity are associated with enhanced coping. More experimental and intervention studies are necessary to support evidence-based resilience practices. Additionally, researchers need to exercise more self-awareness about how stereotypical pejorative paradigms may constrain innovative, strengths-based scholarship.     

Brave new brains: sociology,family and the politics of knowledge

This article critically explores sociological arguments for greater biosocial synthesis, centring contemporary developments in public policy to demonstrate how such a reframing of humanity tends to reinforce existing political orders and socially patterned normativities. The case for further amalgamation of the social and life sciences is examined to suggest that production of somatic markers of truth from relational encounters largely relies upon an anaemic and politically contained version of the social as acquired in early childhood. More specifically, the gendered, classed and culturally specific practice of parenting children has come to occupy a new significance in accounts of social brains and environmentally reactive genomes. This is highlighted through a discussion of ‘early intervention’ as a heavily biologized policy rationale framing opportunities for biosocial collaboration. It is argued that late capitalist objectives of personal investment and optimization are driving this assimilation of the social and life sciences, pursuing an agenda that traces and re‐scores long‐standing social divisions in the name of progress.     

Optimising the trade-off between type I and II error rates in the Bayesian context

For any decision-making study, there are two sorts of errors that can be made, declaring a positive result when the truth is negative, and declaring a negative result when the truth is positive. Traditionally, the primary analysis of a study is a two-sided hypothesis test, the type I error rate will be set to 5% and the study is designed to give suitably low type II error – typically 10 or 20% – to detect a given effect size. These values are standard, arbitrary and, other than the choice between 10 and 20%, do not reflect the context of the study, such as the relative costs of making type I and II errors and the prior belief the drug will be placebo-like. Several authors have challenged this paradigm, typically for the scenario where the planned analysis is frequentist. When resource is limited, there will always be a trade-off between the type I and II error rates, and this article explores optimising this trade-off for a study with a planned Bayesian statistical analysis. This work provides a scientific basis for a discussion between stakeholders as to what type I and II error rates may be appropriate and some algebraic results for normally distributed data.     

Telephone surveys under different frame constructions—evaluating differences in estimates,precision, and cost

Dual-frame, random-digit-dialing (DFRDD) surveys, using a frame of landline telephone numbers and a frame of cell phone numbers, have become the norm for telephone surveys. Two alternative frame constructions sample exclusively from a cell phone frame, referred to as the ‘single-frame cell,’ and sample from the listed landline frame and the cell phone frame, referred to as ‘listed/cell.’ The listed/cell frame construction differs from the DFRDD in that it does not select unlisted-landline frame members. We observe in our simulated data that the listed/cell frame construction results in estimates that more closely approximate the estimates from DFRDD compared with the single-frame cell, results in an improvement in precision compared with the DFRDD that is not as large as the improvement in the single-frame cell, and has lower cost than both the DFRDD and the single-frame cell. We conclude that a listed/cell frame construction might be a better solution than either a DFRDD or single-frame cell frame construction.     

Using Bayesian analysis in repeated preclinical in vivo studies for a more effective use of animals

Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repeated in vivo studies where there is a considerable amount of data from historical control groups, which has potential value. This paper describes our experience with introducing Bayesian analysis for such studies using a Bayesian meta‐analytic predictive approach. This leads naturally either to an informative prior for a control group as part of a full Bayesian analysis of the next study or using a predictive distribution to replace a control group entirely. We use quality control charts to illustrate study‐to‐study variation to the scientists and describe informative priors in terms of their approximate effective numbers of animals. We describe two case studies of animal models: the lipopolysaccharide‐induced cytokine release model used in inflammation and the novel object recognition model used to screen cognitive enhancers, both of which show the advantage of a Bayesian approach over the standard frequentist analysis. We conclude that using Bayesian methods in stable repeated in vivo studies can result in a more effective use of animals, either by reducing the total number of animals used or by increasing the precision of key treatment differences. This will lead to clearer results and supports the “3Rs initiative” to Refine, Reduce and Replace animals in research. Copyright © 2016 John Wiley & Sons, Ltd.     

Advantages of a wholly Bayesian approach to assessing efficacy in early drug development: a case study

This paper illustrates how the design and statistical analysis of the primary endpoint of a proof‐of‐concept study can be formulated within a Bayesian framework and is motivated by and illustrated with a Pfizer case study in chronic kidney disease. It is shown how decision criteria for success can be formulated, and how the study design can be assessed in relation to these, both using the traditional approach of probability of success conditional on the true treatment difference and also using Bayesian assurance and pre‐posterior probabilities. The case study illustrates how an informative prior on placebo response can have a dramatic effect in reducing sample size, saving time and resource, and we argue that in some cases, it can be considered unethical not to include relevant literature data in this way. Copyright © 2015 John Wiley & Sons, Ltd.     

HowParadigms Shape the Stories We Tell: Paradigm Shifts in Gender and Health

The stories we tell about the linkages between gender and health are shaped by the paradigms that guide our inquiries. Paradigms direct our attention away from certain phenomena and toward others. In particular, the dominant paradigms in the study of gender and health have promoted studies of differences, not similarities. Even in the face of strong challenges, many old paradigms persist. Continued reliance on flawed and insensitive paradigms is a major social issue. The aim of this article is to illustrate where we have come from, where we are now, and where we are heading in the study of gender and health. I will do this by tracking changes in the underlying paradigms that have shaped this research area, focusing on the literature in the area of gender and psychosocial factors, especially social-role experiences, and stress-related mental and physical health, to highlight changes that have taken place in these paradigms.     

Spatial heterogeneity in drinking water sources in the Greater Accra Metropolitan Area (GAMA), Ghana

Population and Environment - Universal access to safe drinking water is essential to population health and well-being, as recognized in the Sustainable Development Goals (SDG). To develop targeted...     

Reduced-hours careers in medicine: A strategy for the professional community and the family

This paper discusses the part-time professional career option, a career alternative thought to promote work-family integration, and asks whether this alternative would increase responsiveness to fluctuations in the demand for professionals. For illustrative purposes, we focus on the current oversupply of physicians in the United States, and discuss: (a) existing strategies to reduce this supply; (b) how current full-time schedules restrict professionals' ability to successfully combine work and family; and (c) the potential consequences of promoting part-time careers for the professional community and for families. Este papel describe la opcion de la carrera profesional tiempo medio, una carrera alternativa que se supone provee la integracion de trabajo y familia y hace la pregunta si esta alternativa aumentaria respuestas a altas y bajas en la demanda de profesionales. Para ilustrar, enfocamos en la actual sobre fuente de medicos en los Estados Unidos y discutimos: (a) estrategias existentes para reducir esta fuente; (b) como horarios de tiempo completo existentes resrictan a profesionales que equivale a la abilidad de positivamente combinar el trabajo y la familia; y (c) las consecuencias potenciales de promover carreras a tiempo medio para la comunidad profesional y sus familiares.