Margaret B. Thwaits 《Serials Review》2013,39(2):21-26

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Yann B. Ferrand  Michael J. Magazine  Uday S. Rao 《决策科学》2014,45(5):819-847

In hospitals, the management of operating rooms faces a trade‐off between the need to be responsive to emergency surgeries and to conduct scheduled elective surgeries efficiently. Operating rooms can be configured as flexible and handle both electives and emergencies, or as dedicated to focus on either electives or emergencies. With flexible rooms, the prioritization of emergencies over scheduled electives can lead to schedule disruptions. Focused rooms can lead to imbalances between capacity and surgery workload. Whereas hospital administrators typically handle this trade‐off by employing either flexible rooms (complete flexibility) or dedicated rooms (complete focus), we investigate whether a combination of flexible and dedicated rooms (partial flexibility) could be a preferable alternative. The ensuing question is what is the right combination of flexible and dedicated rooms? A versatile simulation model is developed to evaluate different resource allocation policies under various environmental parameters and performance metrics, including patient wait time, staff overtime, and operating room utilization. The main result is that partial flexibility configurations outperform both complete flexibility and complete focus policies by providing solutions with improved values of expected wait time for both emergency and elective patients.  相似文献   

    

Robert J. Mitkus  David B. King  Mark O. Walderhaug  Richard A. Forshee 《Risk analysis》2014,34(4):735-750

The use of thimerosal preservative in childhood vaccines has been largely eliminated over the past decade in the United States because vaccines have been reformulated in single‐dose vials that do not require preservative. An exception is the inactivated influenza vaccines, which are formulated in both multidose vials requiring preservative and preservative‐free single‐dose vials. As part of an ongoing evaluation by USFDA of the safety of biologics throughout their lifecycle, the infant body burden of mercury following scheduled exposures to thimerosal preservative in inactivated influenza vaccines in the United States was estimated and compared to the infant body burden of mercury following daily exposures to dietary methylmercury at the reference dose established by the USEPA. Body burdens were estimated using kinetic parameters derived from experiments conducted in infant monkeys that were exposed episodically to thimerosal or MeHg at identical doses. We found that the body burden of mercury (AUC) in infants (including low birth weight) over the first 4.5 years of life following yearly exposures to thimerosal was two orders of magnitude lower than that estimated for exposures to the lowest regulatory threshold for MeHg over the same time period. In addition, peak body burdens of mercury following episodic exposures to thimerosal in this worst‐case analysis did not exceed the corresponding safe body burden of mercury from methylmercury at any time, even for low‐birth‐weight infants. Our pharmacokinetic analysis supports the acknowledged safety of thimerosal when used as a preservative at current levels in certain multidose infant vaccines in the United States.  相似文献   

    

Steven B. Kim  Ralph L. Kodell  Hojin Moon 《Risk analysis》2014,34(3):453-464

In chemical and microbial risk assessments, risk assessors fit dose‐response models to high‐dose data and extrapolate downward to risk levels in the range of 1–10%. Although multiple dose‐response models may be able to fit the data adequately in the experimental range, the estimated effective dose (ED) corresponding to an extremely small risk can be substantially different from model to model. In this respect, model averaging (MA) provides more robustness than a single dose‐response model in the point and interval estimation of an ED. In MA, accounting for both data uncertainty and model uncertainty is crucial, but addressing model uncertainty is not achieved simply by increasing the number of models in a model space. A plausible set of models for MA can be characterized by goodness of fit and diversity surrounding the truth. We propose a diversity index (DI) to balance between these two characteristics in model space selection. It addresses a collective property of a model space rather than individual performance of each model. Tuning parameters in the DI control the size of the model space for MA.  相似文献   

    

Sondra S. Teske  Mark H. Weir  Timothy A. Bartrand  Yin Huang  Sushil B. Tamrakar  Charles N. Haas 《Risk analysis》2014,34(5):911-928

The effect of bioaerosol size was incorporated into predictive dose‐response models for the effects of inhaled aerosols of Francisella tularensis (the causative agent of tularemia) on rhesus monkeys and guinea pigs with bioaerosol diameters ranging between 1.0 and 24 μm. Aerosol‐size‐dependent models were formulated as modification of the exponential and β‐Poisson dose‐response models and model parameters were estimated using maximum likelihood methods and multiple data sets of quantal dose‐response data for which aerosol sizes of inhaled doses were known. Analysis of F. tularensis dose‐response data was best fit by an exponential dose‐response model with a power function including the particle diameter size substituting for the rate parameter k scaling the applied dose. There were differences in the pathogen's aerosol‐size‐dependence equation and models that better represent the observed dose‐response results than the estimate derived from applying the model developed by the International Commission on Radiological Protection (ICRP, 1994) that relies on differential regional lung deposition for human particle exposure.  相似文献   

    

D. B. Owen  Faming Ju 《统计学通讯:模拟与计算》2013,42(2):167-179

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A.D.C. Nascimento  G.J.A. Amaral  B.B. Achic  J.T.M. Cruz 《统计学通讯:理论与方法》2013,42(9):2714-2729

Abstract

The aim of this paper is to investigate how some results related to the complex normal distribution are relevant in size and shape analysis. Our main focus is on the derivation of influential measures. In particular, Cook and Kullback–Leibler distances are combined with their respective asymptotic results as well as to an alternative process of defining cut-off points. Some numerical examples illustrate how these measures are used in practice. We perform an application to simulated and actual data. Results provide evidence that the methodology based on Kullback–Leibler distance outperforms one in terms of the Cook classic distance.  相似文献   

    

Stergios B. Fotopoulos  Venkata K. Jandhyala  Kim Heng Chen 《统计学通讯:理论与方法》2013,42(3):613-628

Analytical properties of regression and the variance–covariance matrix of asymmetric generalized scale mixture of multivariate Gaussian variables are presented. The analysis includes an in-depth analytical investigation of the first two conditional moments of the mixing variable. Exact computable expressions for the prediction and the conditional variance are presented for the generalized hyperbolic distribution using the inversion theorem for Fourier transforms. An application to financial log returns is demonstrated via the classical Euler approximation. The methodology is illustrated by analyzing the regression of intraday log returns for CISCO against the corresponding data from S&P 500.  相似文献   

    

Hyung-Tae Ha  Serge B. Provost 《统计学通讯:模拟与计算》2013,42(6):1135-1151

It is shown in this article that, given the moments of a distribution, any percentage point can be accurately determined from an approximation of the corresponding density function in terms of the product of an appropriate baseline density and a polynomial adjustment. This approach, which is based on a moment-matching technique, is not only conceptually simple but easy to implement. As illustrated by several applications, the percentiles so obtained are in excellent agreement with the tabulated values. Whereas statistical tables, if at all available or accessible, can hardly ever cover all the potentially useful combinations of the parameters associated with a random quantity of interest, the proposed methodology has no such limitation.  相似文献   

    

Víctor H. Lachos  Heleno Bolfarine  Reinaldo B. Arellano-Valle  Lourdes C. Montenegro 《统计学通讯:理论与方法》2013,42(9):1769-1786

In this article, we present EM algorithms for performing maximum likelihood estimation for three multivariate skew-normal regression models of considerable practical interest. We also consider the restricted estimation of the parameters of certain important special cases of two models. The methodology developed is applied in the analysis of longitudinal data on dental plaque and cholesterol levels.  相似文献