Extension to higher dimensions of the jaeschke-eicker result on the standardized empirical process

The asymptotic distribution of the sup-norm of the heavily weighted empirical process is established in the multidimensional case. This theorem extends in particular the famous result in Jaeschke (1975, 1979) to higher dimensions. There is a striking difference between the behaviour for higher dimensions and that for dimension one, especially the limiting distribution is now a simple transformation of a standard exponential random variable.     

Inverse-gaussian acceptance sampling plans by variables

Variable sampling plans to control fraction defective are obtained using the Inverse-Gaussian (IG) distribution. OC curves are obtained and impact of sample size and specification limits on these curves are discussed. Simulation studies are used to investigate sensitivity of the sampling plans under the more commonly used normal distribution.     

Marginally oversaturated designs

A special class of supersaturated design, called marginally over saturated design (MOSD), in which the number of variables under investigation (k) is only slightly larger than the number of experimental runs (n), is presented. Several optimality criteria for supersaturated designs are discussed. It is shown that the resolution rank criterion is most appropriate for screening situations. The construction method builds on two major theorems which provide an efficient way to evaluate resolution rank. Examples are given for the cases n=8, 12, 16, and 20. Potential extensions for future work are discussed.     

Goodness of fit for thei ordered categories discrete uniform distribution

Goodness of fit for thei ordered categories discrete uniform distribution can be carried out using Pearson's X² _pstatistic and its components. Applications of this technique are considered and comparisons made with recently suggested empirical uniform distribution     

A note on second order slope rotatable designs over all directions

Hader and Park (1978) introduced second order slope rotatability in axial directions. Park (1987) introduced second order slope rotatabilty over all directions. It is shown that these designs have the additional properly that the sum of the variances of estimates of slopes in all directions at any point is a function of the distance of the point from the design origin.     

The effects of covariate adjustment in generalized linear models

Results from classical linear regression regarding the effects of covariate adjustment, with respect to the issues of confounding, the precision with which an exposure effect can be estimated, and the efficiency of hypothesis tests for no treatment effect in randomized experiments, are often assumed to apply more generally to other types of regression models. In this paper results pertaining to several generalized linear models involving a dichotomous response variable are given, demonstrating that with respect to the issues of confounding and precision, for models having a linear or log link function the results of classical linear regression do generally apply, whereas for other models, including those having a logit, probit, log-log, complementary log-log, or generalized logistic link function, the results of classical linear regression do not always apply. It is also shown, however, that for any link function, covariate adjustment results in improved efficiency of hypothesis tests for no treatment effect in randomized experiments, and hence that the classical linear regression results regarding efficiency do apply for all models having a dichotomous response variable.     

A generalized negative binomial and applications

A generalized negative binomial distribution is derived from the Markov Bernoulli sequence of successes and failures. We study the properties and applications of this distribution. The properties are illustrated by two examples of discrete time queueing systems. The distribution is then fitted to two data sets, the eruption record of Mt. Sangay, and a record of computer disk failure accesses. In the first case there is a strong serial dependence in the data and the generalized negative binomial provides a good fit, while in the second case, although there is a significant serial dependence, it is insufficient to justify the additional parameter of the distribution. We conclude by demonstrating the usefulness of the distribution in the field of statistical quality control.     

P-value adjustment for multiple binary endpoints

The p-value-based adjustment of individual endpoints and the global test for an overall inference are the two general approaches for the analysis of multiple endpoints. Statistical procedures developed for testing multivariate outcomes often assume that the multivariate endpoints are either independent or normally distributed. This paper presents a general approach for the analysis of multivariate binary data under the framework of generalized linear models. The generalized estimating equations (GEE) approach is applied to estimate the correlation matrix of the test statistics using the identity and exchangeable working correlation matrices with the model-based as well as robust estimators. The objectives of the approaches are the adjustment of p-values of individual endpoints to identify the affected endpoints as well as the global test of an overall effect. A Monte Carlo simulation was conducted to evaluate the overall family wise error (FWE) rates of the single-step down p-value adjustment approach from two adjustment methods to three global test statistics. The p-value adjustment approach seems to control the FWE better than the global approach Applications of the proposed methods are illustrated by analyzing a carcinogenicity experiment designed to study the dose response trend for 10 tumor sites, and a developmental toxicity experiment with three malformation types: external, visceral, and skeletal.