Association between sarcopenia and erectile dysfunction in males with type II diabetes mellitus

Background: The prevalence rates for both sarcopenia and erectile dysfunction (ED) gradually increase in middle-aged and elderly diabetic male population and they impair physical functioning, sexual functioning, and quality of life. The aim of the present study was to evaluate the sarcopenia in patients with diabetic ED.

Methods: The study included 98 male patients with type II diabetes mellitus (DM) aged 18–80?years. Blood chemistry and hormone levels were obtained. The International Index of Erectile Function (IIEF-5) questionnaire was administered to the patients. The patients were divided into three groups according to the IIEF-5 score; a score of 5–10 points indicated severe ED, a score of 11–20 indicated moderate ED, and a score of 21–25 points indicated no ED. The muscle mass, handgrip strength, timed up and go test, upper mid-arm circumference, calf circumference, and body mass index were obtained. The statistical analysis was performed using MedCalc Statistical Software version 12.7.7. All parameters were compared between the three groups.

Results: Of 98 patients included in the study, 84 patients had severe sarcopenia, 13 had moderate sarcopenia, while only one patient had normal muscle mass. The mean age was 56.59?±?11.46?years. When patients were divided into three groups according to IIEF-5 score, 38 had severe ED, 39 had moderate ED, and 21 had no ED. There was a significant difference between the three groups in terms of handgrip strength, timed up and go test scores, upper mid-arm circumference, and calf circumference (p?Conclusions: Although muscle mass remains unchanged, muscle strength and physical performance decrease in diabetic ED patients. Diabetic patients with severe and moderate ED have lower muscle strength and physical performance.     

Does Low Willingness to Respond Introduce a Bias? Results from a Socio-epidemiological study among Young Men and Women

The aim of this study was to investigate if willingness to respond can introduce bias in a population survey and to study the socio-economic characteristics of those with high and low willingness to respond. Two groups of final-year pupils at compulsory school were surveyed five years after leaving school, at the age of 21. The data were collected during class meetings, by mailed questionnaires, telephone and personal interviews. The response rates in the studies were proportionally high – about 98% and 90% respectively. In both surveys there were more men compared to women who were late respondents or non-respondents. Long-term unemployment and lack of upper secondary school for both men and women, as well as living with a partner for men, corresponded to low willingness to respond to a survey. A higher alcohol consumption – between 1.5 to 6.5 times – was observed among those with lower willingness to respond. Even a low rate of non-response can introduce a serious bias and produce uncertain results in, for example, studies on the consequences of youth unemployment on alcohol consumption.     

The zero-inflated Poisson model and the decayed, missing and filled teeth index in dental epidemiology

For frequency counts, the situation of extra zeros often arises in biomedical applications. This is demonstrated with count data from a dental epidemiological study in Belo Horizonte (the Belo Horizonte caries prevention study) which evaluated various programmes for reducing caries. Extra zeros, however, violate the variance–mean relationship of the Poisson error structure. This extra-Poisson variation can easily be explained by a special mixture model, the zero-inflated Poisson (ZIP) model. On the basis of the ZIP model, a graphical device is presented which not only summarizes the mixing distribution but also provides visual information about the overall mean. This device can be exploited to evaluate and compare various groups. Ways are discussed to include covariates and to develop an extension of the conventional Poisson regression. Finally, a method to evaluate intervention effects on the basis of the ZIP regression model is described and applied to the data of the Belo Horizonte caries prevention study.     

转基因生物安全立法的动力、压力、阻力探析

法律的制定是一系列力量共同作用的结果,其中既有动力,也有压力和阻力。认真厘清和分析转基因生物安全立法的动力、压力和阻力,有利于推进转基因生物安全的立法进程、提高转基因生物安全法的立法质量。     

Estimating the error distribution function in semiparametric additive regression models

We consider semiparametric additive regression models with a linear parametric part and a nonparametric part, both involving multivariate covariates. For the nonparametric part we assume two models. In the first, the regression function is unspecified and smooth; in the second, the regression function is additive with smooth components. Depending on the model, the regression curve is estimated by suitable least squares methods. The resulting residual-based empirical distribution function is shown to differ from the error-based empirical distribution function by an additive expression, up to a uniformly negligible remainder term. This result implies a functional central limit theorem for the residual-based empirical distribution function. It is used to test for normal errors.     

Sorting people out: The uses of one-dimensional classificatory schemes in a multi-dimensional world

This paper examines how people are classified as part of a labour market project aimed at establishing a process for recognizing prior learning among immigrants to Sweden in order to integrate them more quickly with the labour market and society. The paper suggests that, in Sweden, this work prioritizes procedural effectiveness over a more comprehensive understanding of the competence and qualifications of the immigrant worker. By exploring the process of classification in which cognitive structuring of the perceived world results in organizational, administrative and structural enactment, the study provides further insights into how practices of classification are a central part of organizational life. The concept of intersectionality contributes by showing how individuals are situated at the intersection of a variety of classificatory schemes, and together with classification, intersectionality points to how organizational categories are never given, but a result of bureaucratic power procedures strengthening, weakening and/or negotiating away categories used to sort people out.     

Waivers of parental consent for sexual minority youth

ABSTRACT

The Society for Adolescent Health and Medicine emphasizes the need for research to focus on the health outcomes of sexual minority youth (i.e., lesbian, gay, bisexual, transgender, queer). However, sexual minority youth (SMY) are often less willing to participate in research studies where parental consent is required due to potential victimization and discrimination. This is a major concern given that more research is needed to understand the health needs of this population, especially in terms of suicide, substance use, and HIV prevention. The National Suicide Prevention Strategy classifies SMY as a high-risk group, emphasizing the need to explore suicide risks (along with other health outcomes) among this group. However, this high-risk classification also increases the safeguards necessary to conduct research with this population. Many researchers have argued for waivers of parental consent, but such waivers present with several ethical implications. This article discusses ethical principles, risks, benefits, safeguards, and potential alternative approaches to waivers of parental consent for SMY. We conclude by emphasizing the need for policy changes to allow parental consent waivers for research targeting SMY.     

Identifying and controlling for program-level differences in comparative cost analysis: lessons from the economic evaluation of the National Breast and Cervical Cancer Early Detection Program

Performing economic evaluations of established health care programs is essential to identify and control for underlying program-level variations and to make valid comparisons. At a time when the need for such evaluations is growing, health care professionals have limited information on the methodological challenges of performing these evaluations. In this study, we used the National Breast and Cervical Cancer Early Detection Program to illustrate these potential underlying variations. We performed site visits to four grantees and collected activity-based cost data from nine additional representative programs. We identified five specific types of cost factors that should be considered when evaluating and comparing health care programs: clinical services, service mix, in-kind contributions, indirect costs, and year-to-year expenditures of specific activities. A key lesson is that case studies and pilot testing should be performed before initiating cost analysis to identify underlying variation and to test appropriate methods to adequately control for these differences.     

论竞优及其管理

在阐述竞优行为及竞优思想的基础上,提出了竞优内核的概念,并分析了竞优内核的特性,指出了竞优活动的6个特点,对竞优管理的主要内容和流程进行了分析和阐述。研究表明,竞优是以认识和利用事物规律为前提,以知识为驱动,以展示行为主体优良为目的的一种主流行为;竞优观念可以改善人们认识事物的角度;差异性是竞优的必然现象,而多元化则是竞优群体的某种类型选择结果;竞优能够有效提升行为主体的社会价值,并促进社会组织的发展;建立健全民主集中制是竞优管理的基本要求。