Issues in blinded sample size re-estimation

The utility of blinded sample size re-estimation for clinical trials depends on the ability to estimate variability without providing information about the true treatment difference, and on some reasonable assurance that the method is not likely to cause the sample size to be increased when the treatment effect is better than anticipated. We show that violations of these properties are unlikely to occur in practice.     

360 Video: A prototyping process for developing virtual reality interventions

Abstract

Virtual reality (VR) has emerged as a promising technological intervention for anxiety disorders. However, there are no existing standards and best practices to evaluate the effectiveness of environments to achieve their intervention goals. The purpose of this study was to develop a VR intervention for student veterans with social anxiety disorder and test feasibility utilizing a three-stage development model. The development of a therapeutic VR environment may benefit from an interdisciplinary collaboration of researchers from various fields of study. Utilizing three stages of prototyping with two virtual reality platforms, fully immersive video (n?=?6) and three-dimensional (3-D) immersive virtual reality (n?=?8), the research team designed an intervention for student veterans with social anxiety disorder, testing bio-reactivity of participants. Results of prototyping include user feedback validating increased stress levels and increased bio-reactivity specifically in galvanic skin response and heart rate elevation. Implications include the use of 360° video for prototyping 3-D virtual reality interventions.     

Parenting and child-caretaking among black men who have sex with men and associated sexual and reproductive health factors: a brief report

Abstract

The purpose of this exploratory study was to examine the prevalence of parenting and child-caretaking among a sample of black men who have sex with men (MSM), as well as associations between parenting roles and sexual and reproductive health (SRH) factors. Parenting and SRH data were derived from a survey of 199 black MSM. Nearly half of the sample reported being a father or father-figure (44.4%), almost a third indicated serving as caretaker of a child (29.1%), and one in five have a biological child (20.1%). Over half of the sample reported at least one of these three parenting/child-caretaking roles (52.5%). Two significant differences were observed for sexual health variables: men with biological children were significantly more likely to report using condoms inconsistently (55.0% vs. 35.7%, p = .026) and engaging in transactional sex work (36.8% vs. 21.0%, p = .041). Given the observed prevalence, parenting and child-caretaking among black MSM warrant further inquiry as factors that may influence SRH outcomes and care utilization. Services and interventions tailored to black MSM should consider these men’s potential roles and responsibilities as parents and caretakers of children.     

Attitudes Toward Inheritance Following Divorce and Remarriage

The purpose of this study is to examine attitudes regarding who should be included in wills following divorce and remarriage. Respondents were 268 men and 439 women. In mailed vignettes, they indicated whom they thought should be included in an elder's will. Three variables were examined: (a) family closeness, (b) contact after divorce, and (c) remarriage. Three factors were associated with inheritance obligations: (a) genetic ties, (b) patriarchal lineage, and (c) family ties, which were defined more broadly than genetic relationships. Few respondents mentioned factors such as family closeness and reciprocity. There was little agreement regarding who is and who is not in the family, but inheritance clearly was limited to family. Obligation to include the next of kin in the will supersedes obligations based upon closeness and frequency of contact.     

Long range planning in Bell Canada

The objectives and activities of Bell Canada's Business Planning group are outlined. The Business Planning process of obtaining inputs, organizing the data base, and creating outputs is elaborated. Inputs are derived from original research efforts such as trend extrapolation, Delphi research and survey research. Selected results from Business Planning studies are illustrated. Inputs obtained through secondary research activities are also outlined. The creation of a key-word-indexed on-line information retrieval system to organize the data base is described. The underlying group philosophy of developing outputs that support and/or stimulate the executive decision making process is stressed in the development of Business Planning Outputs.     

Learning by Objectives for Adaptive Shop-Floor Scheduling*

Effective production scheduling requires consideration of the dynamics and unpredictability of the manufacturing environment. An automated learning scheme, utilizing genetic search, is proposed for adaptive control in typical decentralized factory-floor decision making. A high-level knowledge representation for modeling production environments is developed, with facilities for genetic learning within this scheme. A multiagent framework is used, with individual agents being responsible for the dispatch decision making at different workstations. Learning is with respect to stated objectives, and given the diversity of scheduling goals, the efficacy of the designed learning scheme is judged through its response under different objectives. The behavior of the genetic learning scheme is analyzed and simulation studies help compare how learning under different objectives impacts certain aggregate measures of system performance.     

Nuclear Risk Management on Stage: A Decision Analysis Perspective on the UK's Committee on Radioactive Waste Management

In 2003, the UK government set up a broad-based Committee on radioactive waste management (CoRWM) to look at the UK's policy on radioactive waste management with a view to jumpstarting a stalled policy process. The committee's brief was to come up with a set of recommendations that would protect the public and the environment, and be capable of inspiring public confidence. After consulting widely with the public and stakeholders, and drawing on advice from scientists and other experts, CoRWM arrived at a remarkably well-received set of recommendations. On the basis of our experiences of working on CoRWM's multi-criteria decision analysis of different management options, study of CoRWM documentation, and interviews with committee members, we describe the explicit and implicit principles that guided CoRWM. We also give an account of the process by which CoRWM arrived at its conclusions, covering four phases: framing, shortlisting, option assessment, and integration; and four cross-cutting activities: public and stakeholder engagement (PSE), science and engineering input, ethics and social science input, and learning from overseas practice. We finish by outlining some of the key developments in the UK's radioactive waste management process, which followed on from the publication of CoRWM's report, and present our reflections for the benefit of the risk and decision analysts of future committees that, like CoRWM, are charged with recommending to government on the management of technically complex and risky technologies, drawing on extensive public and stakeholder consultation.