On parallel policies for ranking and selection problems

In this paper we develop and test experimental methodologies for selection of the best alternative among a discrete number of available treatments. We consider a scenario where a researcher sequentially decides which treatments are assigned to experimental units. This problem is particularly challenging if a single measurement of the response to a treatment is time-consuming and there is a limited time for experimentation. This time can be decreased if it is possible to perform measurements in parallel. In this work we propose and discuss asynchronous extensions of two well-known Ranking & Selection policies, namely, Optimal Computing Budget Allocation (OCBA) and Knowledge Gradient (KG) policy. Our extensions (Asynchronous Optimal Computing Budget Allocation (AOCBA) and Asynchronous Knowledge Gradient (AKG), respectively) allow for parallel asynchronous allocation of measurements. Additionally, since the standard KG method is sequential (it can only allocate one experiment at a time) we propose a parallel synchronous extension of KG policy – Synchronous Knowledge Gradient (SKG). Computer simulations of our algorithms indicate that our parallel KG-based policies (AKG, SKG) outperform the standard OCBA method as well as AOCBA, if the number of evaluated alternatives is small or the computing/experimental budget is limited. For experimentations with large budgets and big sets of alternatives, both the OCBA and AOCBA policies are more efficient.     

Agent Rationality Behind Network Formation

We search for agent behavior rules which lead to the emergence of social networks that exhibit empirically observed phenomena: small-world property, scale-free degree distribution and stability in time. We assume that agents form and sever links using a cost-benefit analysis. Agents receive benefit from own links and from links that their friends form. On the other hand, link formation, deletion and keeping is costly. We find that a simple model structure which relies only on convex cost of link upkeep leads to stable networks which exhibit the small-world property.     

Insulin resistance,oxidative stress markers and the blood antioxidant system in overweight elderly men

The purpose of the study was to examine in the blood of overweight men aged from 62 to 83 years, the relationships between age and insulin resistance, selected parameters of the oxidative stress, and the antioxidant defense system. The population studied was divided into two groups: the group ‘young-old’ consisted of men aged 62 to 74 years old, and the group ‘old-old’– of men aged between 75 and 83 years. The total antioxidative status (TAS) and concentrations of thiobarbituric acid reactive substances (TBARS) were measured in the blood plasma. In the serum samples, the levels of antibodies against oxidized LDL (oLAB), glucose, total cholesterol, HDL-cholesterol, triglycerides and insulin were measured. Homeostasis Model Assessment of Insulin Resistance (HOMA_IR) was calculated. Concentration of reduced glutathione (GSH) and glutathione peroxidase activity (GPx) were determined in the red blood cells hemolysate. The results of the study did not show significant differences between groups investigated with respect to concentrations of TBARS, TAS, GSH and GPx. However, significantly higher concentrations of glucose and antibodies against oxLDL (p < 0.05) were observed in the group of men over 74 years old in comparison to the group of ‘young-old’ men. It was indicated that the increased insulin resistance and hyperglycemia in elderly men are related to body mass and that they cause intensified oxidative modifications of LDL.     

Post-finasteride syndrome – does it really exist?

Abstract

Inhibitors of 5α-steroid reductase are drugs used to treat androgen-dependent conditions including prostate diseases and androgenic alopecia. Finasteride was the first on the market and is currently the most widely used inhibitor. Dutasteride was the second inhibitor to be approved and has a similar safety profile. Common adverse events of treatment consist of sexual disorders and a negative affect balance. It was described that the prolonged use of 5α-steroid reductase inhibitors in patients with alopecia can cause persistent side effects called a post-finasteride syndrome (PFS), that is not just a simple coexistence of events, but rather a definite syndrome with an iatrogenic background. PFS occurs in susceptible individuals even after small doses of the drug and can last for a long time after the discontinuation of treatment. A deterioration in the quality of life in affected individuals does not justify use of the drug. Wider recognition of PFS symptoms, its incidence, course, prevention, and treatment possibilities will allow the indications for drug use to be reconsidered and treatment to be more personalized. Knowledge about PFS will also help to provide the best treatment for affected individuals and to properly educate patients before obtaining an informed consent for therapy with 5α-steroid reductase inhibitors.     

Two dynamics of globalization in the context of a sports mega-event: the case of UEFA EURO 2012 in Poland

ABSTRACT

The article uses the theoretical framework of Saskia Sassen’s two dynamics of globalization in order to analyse the relations between a nation-state and a non-state global actor when applying and preparing for a sports mega-event, namely UEFA Euro 2012 in Poland. The first dynamic of globalization is created by global institutions, organizations – such as global sport organizations, regimes, and processes. UEFA used the application process, and preparation, to confirm and consolidate its role as a global governor of an increasingly important area of globalization. The way Polish public institutions accommodated the UEFA requirements illustrates the second dynamic of globalization. The context of sports mega-events – ‘organized’ by global sports organizations and ‘hosted’ by nation-states – merges the two dynamics and makes it possible to emphasize the mechanisms involved in forming the new global order, defined by the complex interplay between the nation-state and non-state actors.     

The Transformation of Poland’s Economic System: 1985–1995

Proceeding from Lord Acton’s insight that “exile is the nursery of nationality,” this paper examines a peculiar historical instance of dislocation as a relevant matrix for the articulation of national identity. I inquire into aspects of the elaboration of French national consciousness among French émigrés of the revolutionary period in Russia, approaching the subject at two levels: first, the maîtres à danser, the run-of- the-mill émigrés who abandon cosmopolitan certitudes or pretensions of a “monde français” and abstractions of dynastic loyalty, in favour of nostalgic attachment to a tangible patrie, very much at odds with the Russian otherness into which they have been thrust. Second, the maîtres à penser, those émigré thinkers in whom the Revolution provokes a reconsideration of established universals and who conceptualize Russia in terms of a project to reconcile universal and particular or national values. I examine the dilemmas and ultimate failure of such a projection by focusing on the work of Joseph de Maistre. On both levels, the historical case studied here is an exemplification of the proposition that nationalism is founded on a disenchantment with the world, and that physical estrangement from both the world to which one believes oneself to belong as well as spiritual estrangement from the world in which one treads, may provide a critical context for defining collective identity.     

Historical Heritage in Contemporary Polish Law Relating to Foreigners

The Polish diaspora living around the world is best described as an inheritance of the turbulent history of Poland. For decades, citizens of Polish origin from various states have been trying to maintain ties with their kin and country. During communist times, citizens of Eastern European countries (including the Soviet republics) could not enjoy free contacts across borders. Poland's accession to the European Union and Schengen area has created new barriers for third country nationals willing to come and stay in Poland. Therefore, any facilitation or exemption from visa requirements is very attractive for them. Legal instruments relating to foreigners which have recently been adopted in Poland affect the situation of Polish minorities and the rights of their members. The author reveals the historical roots of the legal solutions and indicates the specificity of Polish immigration law. First, she considers the historical background of the links between immigration law and minority rights, particularly in the area of economy, culture and education. She comes to the conclusion that well-constructed immigration provisions may be useful in filling gaps in the protection of minorities and that the new ways of acquisition of citizenship may to some extent compensate old harms and injustice.