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Human longevity is a complex phenotype with a strong genetic contribution. The search for allelic variation that impacts on longevity often involves population-based association studies of long-lived individuals (centenarians and nonagenarians) and younger controls. A major methodological problem with this approach is that the cases and controls in these experiments are often born several generations apart. The inherent absence of "age matching" can lead to serious misinterpretations. For example, allele frequency differences between long-lived individuals and younger controls may not reflect an effect on longevity but rather a change in population structure over time or different gene-environment interactions across generations. 相似文献
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Stefan Mittnik 《统计学通讯:理论与方法》2013,42(11):3825-3831
Closed form expressions for the theoretical autocovariance and autocorrelation function of mixed autoregressive moving average processes are presented. The results provide insight into the construction of autocovariances and autocorrelatians and are useful in theoretical analysis, model identification as well as in implementing maximum likelihood estimation algorithms. 相似文献
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Komalsingh Rambaree Stefan Sjöberg Päivi Turunen 《Journal of Community Practice》2019,27(3-4):231-248
ABSTRACTThe aim of this article was to identify and discuss ecosocial changes and community resilience mechanisms in a coastal fishing community of Sweden – Bönan. Data were collected through eight semi-structured interviews and field observations. An abductive thematic analysis was used to analyze data and background literature. The findings showed that Bönan has been exposed to a combination of ecosocial changes that have transformed the community, and therefore required community resilience interventions. This article concludes that social workers need to take an active part in ecosocial work for enhancing community resilience. 相似文献
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[Abstract] Based on a single and on two independent samples, joint confidence regions for parameters of Pareto distributions are proposed with minimum volume properties and without assigning the confidence level to dimensions. In the one-sample case, comparisons are made to former simultaneous confidence sets for Pareto parameters by means of simulation and a real data set. The two-sample case is studied in various set-ups and comprises simultaneous confidence regions for the shape parameters, the scale parameters, and higher-dimensional vectors of these parameters, where common shape and common scale models are also considered. 相似文献
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Katinka Fischer Christoph Bothung Felix Lieder Stefan Wolfart Holger Schwender 《Journal of applied statistics》2019,46(10):1822-1842
In several research areas such as psychology, social science, and medicine, studies are conducted in which objects should be ranked by different judges/raters and the concordance of the different rankings is then analyzed. In such studies, it is also frequently of interest to compare the rankings between different groups of judges, e.g. female vs. male judges or judges from different professions. In the two-group case, the two-group concordance test of Schucany & Frawley can be employed for such a comparison. In this article, we propose an extension of this test enabling the comparison of rankings from more than two groups of judges. This test aims to detect disagreement in the average rankings of the objects between k groups with an at least moderate intra-group concordance. We evaluate this test in an extensive simulation study and in an application to data from an aesthetics study. This simulation study shows that the proposed test is able to detect differences between average rankings and performs well even in situations in which the disagreement is comparably small or the intra-group concordance is inhomogeneous. 相似文献
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Emelie Shanks Ulf Jonsson Stefan Wiklund Alexander Rozental 《Child & Family Social Work》2020,25(1):92-99
Research concerning outcomes for children who have been placed in out‐of‐home care has indicated that the care may have unwanted consequences. However, there has been no coherent terminology for differentiating between different types of such unwanted consequences. In this article therefore, we attempt to disentangle different aspects of potentially harmful care for looked after children, as well as to discuss potential pathways to more systematically approach and report adverse events for this group. In this endeavour, we turn to two adjacent disciplines, medicine and psychology, where these issues have received more interest. The applicability of the concepts used in these fields is discussed, and it is concluded that although they provide some help in categorizing different aspects of harmful care, the complexity of out‐of‐home care makes existing models difficult to adopt without adjustments. This has consequences for the possibility of evaluating care in research, as well as for monitoring adverse events in practice. Importantly, the causality will often be unknown. We therefore suggest that it is essential to shed more light on how decisions should be made about when to intervene or not in out‐of‐home care, despite limited information. 相似文献