排序方式: 共有36条查询结果,搜索用时 765 毫秒
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Conditional power calculations are frequently used to guide the decision whether or not to stop a trial for futility or to modify planned sample size. These ignore the information in short‐term endpoints and baseline covariates, and thereby do not make fully efficient use of the information in the data. We therefore propose an interim decision procedure based on the conditional power approach which exploits the information contained in baseline covariates and short‐term endpoints. We will realize this by considering the estimation of the treatment effect at the interim analysis as a missing data problem. This problem is addressed by employing specific prediction models for the long‐term endpoint which enable the incorporation of baseline covariates and multiple short‐term endpoints. We show that the proposed procedure leads to an efficiency gain and a reduced sample size, without compromising the Type I error rate of the procedure, even when the adopted prediction models are misspecified. In particular, implementing our proposal in the conditional power approach enables earlier decisions relative to standard approaches, whilst controlling the probability of an incorrect decision. This time gain results in a lower expected number of recruited patients in case of stopping for futility, such that fewer patients receive the futile regimen. We explain how these methods can be used in adaptive designs with unblinded sample size re‐assessment based on the inverse normal P‐value combination method to control Type I error. We support the proposal by Monte Carlo simulations based on data from a real clinical trial. 相似文献
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Raeymaeckers Peter Vermeiren Caroline Noël Charlotte Van Puyvelde Stijn Willems Jurgen 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》2020,31(5):1037-1048
VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - In this research, we focus on the governance role of the coordinator affiliated to the leading agency in... 相似文献
24.
Families of adult people with disability: Their experience in the use of services run by social cooperatives in Italy 下载免费PDF全文
Social cooperation has historically played a pivotal role in developing socio‐educational services for people with disability, thereby contributing to counteracting the social isolation often associated with this condition. Using a mixed‐method methodology, this study maps the diversity of perspectives on how the use of disability‐related services run by social cooperatives impacts on and becomes meaningful to family life. One hundred twenty‐nine interviews with family members of adults with different kinds of disability were studied using emotional textual analysis. It provides a multi‐dimensional model to read and map the multiplicity of emotional meanings related to disability and the use of services, shedding light on key diversities in how family members emotionally make sense of care and support. The results reveal the importance of supporting family‐carers on two main issues: accessing a less passive representation of their relative with disability; and being able to test and acknowledge limits without succumbing to a sense of powerlessness. 相似文献
25.
Although face-to-face events starring film professionals have become increasingly popular, they have rarely been studied, especially from the perspective of production. Focusing on the phenomenon of Chinese movie roadshows, this study explores the motivations and techniques used to produce popular media events in the Chinese film industry. Based on expert interviews with 15 media practitioners, the results showed that roadshows are staged as ritualized events that are centered on the performance of a symbolic boundary between “inside” and “outside” the media. Film industry professionals embrace face-to-face communication with audiences and use such events to display sincerity, producing them as a seemingly “unmediated” peek behind the veil of an otherwise hidden world. Moreover, communication on social media is another form of ritualized practice. We conclude that, by thus mediating the “unmediated,” movie roadshows offer an insightful perspective on the machinery of media power in China. 相似文献
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Stijn Joye 《Sociology Compass》2014,8(8):993-1003
This article provides an overview of the research and literature on media and disasters. Drawing on the central idea of a disaster as a social and media construction, I identify this young and rapidly emerging body of research as an inherent interdisciplinary area that has attracted the interest of many disciplines within social sciences. A first section of the article focuses on a characterization of (mediated) disasters and the question of academic relevance. Second, I adopt a historical perspective to reflect on issues of disciplinary concern, followed by an outline of the contemporary body of literature. In the final section, directions to advance future research on media and disasters are discussed. 相似文献
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Performance Analysis of Exponential Multi-Server Production Lines with Fluid Flow and Finite Buffers
This article presents an approximation method for fluid flow production lines with multi-server workstations and finite buffers. Each workstation consists of parallel identical servers, which are subject to operation-dependent failures with exponentially distributed uptimes and downtimes. The proposed method decomposes the production line into single-buffer subsystems, each described by a continuous state Markov process, the parameters of which are determined iteratively. The approximation method is appropriate for the analysis of longer production lines, able to accurately estimate performance characteristics (e.g., throughput and mean buffer content), and shown to perform well on a large test set. 相似文献
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Stijn Daenekindt 《Social indicators research》2017,133(1):15-30
The dissociative thesis states that social mobility is a disruptive and detrimental experience for the individual. Despite the absence of convincing evidence either for or against it, this thesis is generally accepted in sociology. I investigate this thesis by considering three dimensions of dissociation—i.e., social isolation, utilitarian individualism, and social disorientation. I use data from a large-scale survey in Flanders (Belgium) and apply Diagonal Reference Models to study consequences of intergenerational social mobility. I find support for asymmetric acculturation for each dimension, i.e., upwardly mobile individuals adapt more to the new social status position, compared to downwardly mobile individuals. Moreover, both for social disorientation and utilitarian individualism, I find detrimental effects of the experience of downward social mobility. As I find no detrimental consequences of both upward and downward mobility, the results do not provide evidence for the dissociative thesis. 相似文献
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Claudia Claes Geert Van Hove Jos van Loon Stijn Vandevelde Robert L. Schalock 《Social indicators research》2010,98(1):61-72
As the concept of quality of life (QOL) has evolved from a theoretical concept to both a measurable construct and an action-oriented
change agent in the field of intellectual disabilities, there has emerged a corresponding need to develop, implement, and
use a systematic approach to the assessment of domain-referenced quality of life outcomes. The purpose of this article is
to suggest eight principles based on published literature and the authors’ experiences that should underlie the assessment
of QOL-related personal outcomes in the field of intellectual disabilities. Data from the development of the personal outcomes scale are used to exemplify each principle. The article’s premise is that model development and test construction should work in
tandem, and that a ‘quality of life assessment instrument’ should be based on an empirically derived QOL conceptual and measurement
framework/model. 相似文献
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Elga Sikkens Stijn Sieckelinck Marion van San Micha de Winter 《Child & Family Social Work》2017,22(2):1044-1053
This paper focuses on radicalization from a parenting perspective; we propose an approach that sees radicalization as a possibility in adolescent development, and as part of the interaction with the adolescent's social environment and socialization. The aim of the study is to discover how parents react when their adolescent develops extreme ideals. Using 55 in‐depth interviews with young people who have extreme ideals and their parents, the parental reactions towards these ideals are explored. Subsequently, the reactions are categorized according to two dimensions (control and support). This study shows how parents struggle when confronted with radicalization and shift to less demanding responses due to powerlessness, dissociation and parental uncertainty. 相似文献