Fitting E(max) models to clinical trial dose-response data

We consider fitting Emax models to the primary endpoint for a parallel group dose–response clinical trial. Such models can be difficult to fit using Maximum Likelihood if the data give little information about the maximum possible response. Consequently, we consider alternative models that can be derived as limiting cases, which can usually be fitted. Furthermore we propose two model selection procedures for choosing between the different models. These model selection procedures are compared with two model selection procedures which have previously been used. In a simulation study we find that the model selection procedure that performs best depends on the underlying true situation. One of the new model selection procedures gives what may be regarded as the most robust of the procedures.     

The context of decision-making in cases of child neglect

This paper explores professional decision-making in cases of child neglect within the context of child protection practice in Britain. The literature on the nature of neglect is reviewed. Difficulties associated with decision-making are then examined within a framework that addresses the social, political and organizational context of child protection practice. It is argued that the current system, which focuses on incidents of abuse rather than the context of children's lives, provides inadequate protection for many children experiencing chronic neglect. Conclusions are drawn with regard to the development of practice that supports vulnerable parents while still remaining the child's welfare as paramount. © 1998 John Wiley & Sons, Ltd.     

Victimization and Violence: An Exploration of the Relationship Between Child Sexual Abuse,Violence, and Delinquency

Child sexual abuse (CSA) continues to be a major public health issue with significant short- and long-term consequences. However, little contemporary research has examined the relationship between CSA and delinquent and violent behavior in adolescence. Children who have been sexually abused experience a unique form of victimization compared to children who have endured other forms of maltreatment, as CSA can result in feelings of shame, powerlessness and boundary violations. The purpose of this study was to examine the effect of CSA on delinquent and violent behavior in adolescence. We examined self-report data at the age 18 interview from the Longitudinal Studies of Child Abuse and Neglect (LONGSCAN) on measures of sexual abuse experience, and engagement in delinquent and violent behavior in the past year. All participants reported either a history of maltreatment or were identified at-risk based on demographic risk factors. Participants included 368 males and 445 females who self-reported experiences of CSA and delinquent and violent behavior (N = 813). Findings indicated that, when controlling for gender and race, the odds of engagement in delinquent and violent behavior for those who have experienced CSA are 1.7 times higher than for those who have not. Additionally, female victims of CSA were .52 times less likely to engage in violent and delinquent behavior compared to their male counterparts. Further efforts are needed to examine the effects of CSA on violent and delinquent behavior to better guide treatment efforts that prevent juvenile justice involvement.     

Entre « passion » et incertitude : la socialisation au métier de footballeur professionnel

On the basis of a socioethnographic survey conducted in a professional soccer training center in France, the means of occupational socialization are analyzed in this demanding, captivating institution. Light is shed on how trainees appropriate this professional world and its requirements. As they enter this social universe, they encounter a key tension. On the one hand, training calls for a heavy investment that trainers and trainees experience as a “passion” and understand as being separate from the world of “ordinary” work. On the other hand, it is also a major source of uncertainty as to trainees’ prospects, given its intense selectivity and the few outlets in the labor market. It requires of trainees a strong commitment in time, body and spirit with prospects so uncertain that the course of training is seldom free from periods of soul-searching.     

The effects of preconception desires and intentions on pregnancy wantedness

Do preconception intentions to conceive add to the prediction of pregnancy wantedness beyond the effect of preconception desires? This paper addresses that question, using data regarding the most recent pregnancy of 2,299 women respondents to the 2002 U.S. National Survey of Family Growth. We test a structural equation model predicting a woman’s pregnancy wantedness with her preconception desires, her perception of her partner’s preconception desires, and her preconception intentions. In this multivariate setting, preconception intentions do not predict pregnancy wantedness in the overall sample. However, they do predict wantedness in certain demographic contexts. We identify three patterns of change in our model that occur in selected contexts. We then use these patterns to hypothesize three psychosocial mechanisms by which preconception intentions may increase the wantedness of a pregnancy beyond that resulting from the woman’s preconception desires to get pregnant and her perception of her partner’s preconception desires.     

META-DESIGN CONSIDERATIONS IN DEVELOPING MODEL MANAGEMENT SYSTEMS*

This paper examines cognitive considerations in developing model management systems (MMSs). First, two approaches to MMS design are reviewed briefly: one based on database theory and one based on knowledge-representation techniques. Then three major cognitive issues—human limitations, information storage and retrieval, and problem-solving strategies—and their implications for MMS design are discussed. Evidence indicates that automatic modeling, which generates more complicated models by integrating existing models automatically, is a critical function of model management systems. In order to discuss issues pertinent to automatic modeling, a graph-based framework for integrating models is introduced. The framework captures some aspects of the processes by which human beings develop models as route selections on a network of all possible alternatives. Based on this framework, three issues are investigated: (1) What are proper criteria for evaluating a model formulated by an MMS? (2) If more than one criterion is chosen for evaluation, how can evaluations on each of the criteria be combined to get an overall evaluation of the model? (3) When should a model be evaluated? Finally, examples are presented to illustrate various modeling strategies.     

“Roll back the years”: A study of grandparent special guardians' experiences and implications for social work policy and practice in England

Growing numbers of grandparent special guardians (GSGs) are assuming responsibility for increasing numbers of children in the care system in England. Special guardianship arrangements are increasingly used as a permanency option as they allow children to remain in their kinship networks rather than in local authority care or be adopted; yet there is a scarcity of research on GSG carers' experiences. This paper reports a small qualitative research study where 10 sets of grandparents were interviewed to explore their journey to becoming GSGs and to theorize their subsequent experiences. Two themes emerge. First, experiences of the assessment process are elaborated, decisions often being made at a time of family crisis, impacting on GSGs: financial, employment, and relational. Second, GSGs' experiences of managing often challenging relationships and contact arrangements between the grandchildren and the parents reveal three main relationship management approaches emerging: containing‐flexible, containing‐controlled, and uncontained/defeated approaches. Anthropological concepts of affinity help theorize the GSGs' ambivalent responses to becoming carers in later life, enabling reconfigured kinship relationships in new family forms. Family policy and social work practice is critiqued as GSGs appear often left alone to “roll back the years,” to heal previous harms done to the grandchildren who end up in their care.     

Sklair,L. The Icon Project: Architecture,Cities and Capitalist Globalization 2017 New York: Oxford University Press 352 pp. £26.49 (hardback) ISBN: 9780190464189

Architecture embeds capital. Theoretical and empirical sociology has addressed a wide variety of social contexts with the aim of illuminating how architecture provides both i) the sites and settings in which labour relations are manifest; and ii) a symbolic intervention that sees accumulation and power celebrated. Against this backdrop, Leslie Sklair's book The Icon Project: Architecture, Cities and Capitalist Globalization contributes significantly to our understanding of how architecture is entangled with the contemporary operation of international capital. Sklair's account argues that iconic architecture ‐ those landscape‐dominating buildings designed by so‐called ‘starchitects’ who are famous in their own right and have a strong aesthetic brand‐exists through and for the further generation of surplus value. Particularly sociological in orientation, The Icon Project adds much to our understanding of the architectural celebration of the transnational consumption and production practices that underpin deeply uneven cities the world over.