Nonparametric estimation of the survival distribution in censored data

Two nonparametric estimators o f the survival distributionare discussed. The estimators were proposed by Kaplan and Meier (1958) and Breslow (1972) and are applicable when dealing with censored data. It is known that they are asymptotically unbiased and uniformly strongly consistent, and when properly normalized that they converge weakly to the same Gaussian process. In this paper, the properties of the estimators are carefully inspected in small or moderate samples. The Breslow estimator, a shrinkage version of the Kaplan-Meier, nearly always has the smaller mean square error (MSE) whenever the truesurvival probabilityis at least 0.20, but has considerably larger MSE than the Kaplan-Meier estimator when the survivalprobability is near zero.     

Comparison of tests for bivariate symmetry versus location and/or scale alternatives

This paper studies the performance of tests which use a null hypothesis of bivariate symmetry and detect the broad class of location and/or scale alternatives . The conditionally distribution-free tests of Sen (1967) and Hollander (1971) and parametric tests related to those of Bell and Haller (1969) are compared in a Monte Carlo study which also includes a new conditionally distribution-free test.     

An approximation for analyzing a broad class of implicitly and explicitly defined estimators

An approximation is presented that can be used to gain insight into the characteristics – such as outlier sensitivity, bias, and variability – of a wide class of estimators, including maximum likelihood and least squares. The approximation relies on a convenient form for an arbitrary order Taylor expansion in a multivariate setting. The implicit function theorem can be used to construct the expansion when the estimator is not defined in closed form. We present several finite-sample and asymptotic properties of such Taylor expansions, which are useful in characterizing the difference between the estimator and the expansion.     

A four-moment approach and other practical solutions to the behrens-f1sher problem

Fixed sample size approximately similar tests for the Behrens-Fisher problem are studied and compared with various other tests suggested in current sttistical methodelogy texts. Several fourmoment approxiamtely similar tests are developed and offered as alternatives. These tests are shown to be good practical solutions which are easily implemented in practice.     

Handling cause of death in equivocal cases using the em algorithm

The statistical analysis of animal bioassays fore carcinogenicity often involves utilizing the cause of death of each animal. There is considerable disagreement among veterinary pathologists as to the reliability of cause of death information. Recent recommendations for assigning cause of death in animal studies have allowed for uncertainty on the part of the pathologist. This has given rise to data that contain acknowledged equivocal cases with respect to cause of death. The present paper proposes a method for incorporating these equiYocal cases into an existing estimation procedure that requires distinguishing between tumors that caused death and those that did not.     

Option pricing for generalized distributions

The Black Scholes formula has been widely used to price financial instruments. The derivation of this formula is based on the assumption of lognormally distributed returns which is often in poor agreement with actual data. An option pricing formula based on the generalized beta of the second kind (GB2) is presented. This formula includes the Black Scholes formula as a special case and accommodates a wide variety of nonlognormally distributed returns. The sensitivity of option values to departures from the skewness and kurtosis associated with the lognormal distribution is investigated.     

Approximating discrete multivariate distributions prom known moments

To approximate the joint distribution of the two-colony stepping-stone model, a finite mixture approach is proposed for constructing discrete multi-variate distributions. This approach generahzes the classic method of linear combinations of independent variables. The stepping-stone model is approximated through matching known moments. Numerical examples from entomology are given. Comparisons are made with the work by Wehrly et al (1993).     

Assessing multiple endpoints with ordered alternatives

Nonparametric approaches to the analysis of multiple endpoints in clinical studies can be of particular value when the endpoints are heterogeneous or distributional assumptions are suspect. We describe a multivariate Terpstra-Jonckheere U-statistic for assessing multiple endpoints with ordered alternatives, and illustrate its use with data arising from a recent clinical study.     

Sample design for observing classes of objects

We consider optimal sample designs for observing classes of objects. Suppose we will take a simple random sample of equal-sized sectors from a study population and observe the classes existing on these sectors. The classes might be many different things, for example, herbaceous plant species (in sampling quadrats), microinvertebrate species (in sampling cores), and side effects from a drug (in conducting medical trials). Under a nonparametric mixture model and data from a previous related study, we first estimate the optimal number of sample sectors of a given size. Then for negative binomial dispersions of individuals with a common aggregation parameter k, we consider the optimal size as well as number of sample sectors. A simple test exists to check our common k assumption and our optimal size method requires far less data than would be required by a grid method or other method which utilizes data from sample sectors of several different sizes.