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Martin J. Wolfsegger Alexander Bauer Detlew Labes Helmut Schütz Richardus Vonk Benjamin Lang Stephan Lehr Thomas F. Jaki Werner Engl Michael D. Hale 《Pharmaceutical statistics》2021,20(2):272-281
For the clinical development of a new drug, the determination of dose-proportionality is an essential part of the pharmacokinetic evaluations, which may provide early indications of non-linear pharmacokinetics and may help to identify sub-populations with divergent clearances. Prior to making any conclusions regarding dose-proportionality, the goodness-of-fit of the model must be assessed to evaluate the model performance. We propose the use of simulation-based visual predictive checks to improve the validity of dose-proportionality conclusions for complex designs. We provide an illustrative example and include a table to facilitate review by regulatory authorities. 相似文献
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Serrat Rodrigo Scharf Thomas Villar Feliciano 《Voluntas: International Journal of Voluntary and Nonprofit Organizations》2022,33(3):615-626
VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - Research on older people’s civic engagement has increased significantly in the last two decades, as have policy and... 相似文献
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Under the high‐stakes accountability regime, narrower curricula and/or teaching to narrower tests can restrict the range of skills students acquire. We develop a theory of skill range restriction at the state level. The analysis focuses on math and reading skills in fourth and eighth grade between 2003 and 2009. At both grade levels, the average student’s range of math and reading skills expanded, but there was considerable between‐state variation. In fourth grade, math and reading skills were affected in different ways by percentages of African American and Hispanic students in the state, average class size, and political conservatism. In eighth grade, math and reading skills were restricted, respectively, by lower per‐pupil revenue and lower average adult income. Skill range restriction was associated with greater proficiency gains, since students needed to demonstrate proficiency in fewer skills. An exception was in fourth‐grade reading, for which we observed the opposite pattern. 相似文献
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Ian Thomas 《Child & Family Social Work》2019,24(3):407-408
This paper offers a brief consideration of the internal and external factors impacting children and young people who have become in conflict with the law. 相似文献
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