Three-stage designs for monitoring clinical trials

Optimal three-stage designs with equal sample sizes at each stage are presented and compared to fixed sample designs, fully sequential designs, designs restricted to use the fixed sample critical value at the final stage, and to modifications of other group sequential designs previously proposed in the literature. Typically, the greatest savings realized with interim analyses are obtained by the first interim look. More than 50% of the savings possible with a fully sequential design can be realized with a simple two-stage design. Three-stage designs can realize as much as 75% of the possible savings. Without much loss in efficiency, the designs can be modified so that the critical value at the final stage equals the usual fixed sample value while maintaining the overall level of significance, alleviating some potential confusion should a final stage be necessary. Some common group sequential designs, modified to allow early acceptance of the null hypothesis, are shown to be nearly optimal in some settings while performing poorly in others. An example is given to illustrate the use of several three-stage plans in the design of clinical trials.     

Tell Your Stories about China

I have just finished writing my new book and I appreciate the efforts of everyone who has written stories for "My Foreign Teacher and I "essay contest. Those which I read left me with the knowledge that their experiences were all worth sharing and writing about. Whether foreign teachers or Chinese students, both have had     

The folder feedback system: Making research content more understandable,enjoyable, and usable 1

This paper describes the use and evaluation of the folder feedback system. The folder feedback system is a useful teaching tool based in principles of adult learning. It is designed to help organize student learning, increase communication with the instructor, insert an element of fun into the class, and assist with student/teacher relationship building. An evaluation of the teaching tool produced mixed results. The treatment group received higher grades than the comparison group, yet in all other measures no differences were found.     

The impact of newsroom changes and the rise of social media on the practice of media relations

Recent changes in American media have resulted in direct impacts on the work of PR professionals, from newsroom reductions in traditional media outlets to the rise of social media. This study examines changes in the media relations dynamic with qualitative, in-depth interviews from 12 PR professionals in a medium, eastern U.S. city. Findings include PR professionals doing less traditional media relations, mostly attributable to downsized newsrooms, and frustration with the resulting dearth of institutional knowledge, influx of young, inexperienced reporters, and shallow stories. While participants see opportunities to inject unfiltered messages in media, overall they value reporter relationships and using social media in communication with them and in their job. Although new media are seen as one more task on an already very full PR plate, participants acknowledge their importance and growing relevance. Overall, PR professionals see their and the industry's future including both traditional and new media.     

Extension of two-sided test to multiple treatment trials

In a two-treatment trial, a two-sided test is often used to reach a conclusion, Usually we are interested in doing a two-sided test because of no prior preference between the two treatments and we want a three-decision framework. When a standard control is just as good as the new experimental treatment (which has the same toxicity and cost), then we will accept both treatments. Only when the standard control is clearly worse or better than the new experimental treatment, then we choose only one treatment. In this paper, we extend the concept of a two-sided test to the multiple treatment trial where three or more treatments are involved. The procedure turns out to be a subset selection procedure; however, the theoretical framework and performance requirement are different from the existing subset selection procedures. Two procedures (exclusion or inclusion) are developed here for the case of normal data with equal known variance. If the sample size is large, they can be applied with unknown variance and with the binomial data or survival data with random censoring.     

Accounting for Everyday Incivility: an Australian study

The question of how we live among strangers in daily life is an established concern in contemporary social analysis. A key topic has been the achievements of the individual in rendering daily life among unknown others possible. Yet, questions of residual failure await full development. The study aims to describe the results of an Australian study that examined the significance and meaning of interactional breakdown with strangers in everyday life for the contemporary individual. Focus group methodology is used to describe common threads of understanding that ordinary people have developed around such events in terms of prevalence, reasons and remedies. Noteworthy findings are (i) the use of period and generational kinds of historical thinking in lay reflections on the state of everyday incivility (ii) the materialization of excessive individualism, runaway capitalist values and diminished community as key ideas within lay talk about the generators of everyday incivility, and (iii) the articulation of communitarianism as a preferred panacea to everyday incivility for lay actors.     

After the highwayman: Syntax and successful placement of press releases in newspapers

This study proves once again that too many press releases are poorly written and over-written, with long sentences and paragraphs, and poor syntax as well as weak and passive construction. In their use of press releases, journalists almost always have to make them simpler, shorter, easier to read, and less passive.The authors conclude that success in writing of press releases requires brevity and simplicity, shorter paragraphs, sentences, and words, and the elimination of the passive voice.Timothy Walters is an assistant professor of communication at Stephen F. Austin State University in Nacogdoches, TX. Lynne Walters is associate professor of journalism and Douglas Starr professor of journalism, both at Texas A&M University, College Station. Lynne Walters is currently a Fulbright professor at the American Journalism Center in Budapest, where her husband Timothy is also on a one-year appointment as a visiting professor.     

The psychological development of prelinguistic deaf infants

This paper will discuss the emotional developmental problems displayed by those who are deaf at birth. In order to provide an in-depth understanding of the emotional needs of the prelinguistic infant the distinctive perspectives and concerns of various developmental psychologies will be reviewed. The tremendous need for mental health and social work services for the deaf population and their families has been rarely discussed, therefore, the last stage of this presentation will provide some suggestions for clinical treatment and prevention programs for deaf individuals.     

Ego Development and Adolescent Academic Achievement

This study investigated ego developmental differences in adolescent academic orientations and academic achievement. A sample of 142 male and female high school students completed the Washington University Sentence Completion Test and self‐report measures assessing academic locus of control, learning orientation (LO), and grade orientation (GO). With increasing ego development, adolescents demonstrated increased internal academic locus of control, stronger LOs, diminished GOs, and higher class rank. Regression analysis indicated that ego level was a significant predictor of academic achievement after controlling for the effects of verbal intelligence and gender. Implications for fostering academic success through theoretically relevant interventions are discussed.