Structure and Parameterization of Pharmacokinetic Models: Their Impact on Model Predictions

There has been an increasing interest in physiologically based pharmacokinetic (PBPK)models in the area of risk assessment. The use of these models raises two important issues: (1)How good are PBPK models for predicting experimental kinetic data? (2)How is the variability in the model output affected by the number of parameters and the structure of the model? To examine these issues, we compared a five-compartment PBPK model, a three-compartment PBPK model, and nonphysiological compartmental models of benzene pharmacokinetics. Monte Carlo simulations were used to take into account the variability of the parameters. The models were fitted to three sets of experimental data and a hypothetical experiment was simulated with each model to provide a uniform basis for comparison. Two main results are presented: (1)the difference is larger between the predictions of the same model fitted to different data se1ts than between the predictions of different models fitted to the dame data; and (2)the type of data used to fit the model has a larger effect on the variability of the predictions than the type of model and the number of parameters.     

Working part‐time: achieving a successful ‘work‐life’ balance?1

The role of part-time employment in the balancing of women's employment and family lives has generated an immense literature. Using data on women working part-time and full-time in different level occupations in the British Household Panel Survey, this paper argues that it is now vital to move these balancing debates on from their location within work-family rhetoric and to re-position the study of women's working time in broader work-life discussions. Work-family debates tend to neglect a number of key domains that women balance in their lives, in addition to family and employment, including their financial security and their leisure. The paper shows that examining the financial situations and the leisure lives of female part-timers in lower level jobs reveals a less positive picture of their 'life balancing' than is portrayed in much work-family literature. Instead, they emerged as the least financially secure employees and, linked to this, less satisfied with their social lives too. It is concluded that since the work-life system is multi- and not just two-dimensional, it is important to examine how all life domains interrelate with each other. In this way, we would be in a better position to begin to assess all the benefits and disadvantages associated with working part-time and with other work-life balancing strategies.     

嘉士伯的“必胜之战”

2001年，嘉士伯和奥克拉两家公司合并组成了现在的嘉士伯酒业，一时间，公司在销售渠道和品牌阵容上实力大增。但由于啤酒行业的竞争正变得日趋激烈，这次合并只能被看成是嘉士伯漫长旅程的开始。     

SIN,SAINTS, AND SHEEP IN SARDINIA 1

Narratives of Catholicism, gender, and criminality are entangled with social constructions of ‘resistance’ to a new Gennargentu National Park on areas of traditional common lands in central Sardinia, Italy. Embodied identities are strategically implicated in moral discourses of grassroots opposition to a park. The notion of Sardinian resistance as a form of cultural authenticity is rooted in a local sphere of social practices and expectations that are not shared by the wider Italian or European public. Ethnography in the town of Orgosolo demonstrates that a ‘politics of the weak’ can reframe relations of authority in local spheres and work to empower cultural recognition and control over common lands. Transgressive acts of violence, however, highlight embedded tensions, ambiguities, and disruptions in local identity practices. The gendered construction of cultural discourses in Orgosolo points to the paradox of a politics that seeks to affirm the authority of embodied traditions yet actually perpetuates ambivalent stereotypes based on cultural essentialism.     

The Role of Heritage Camps in Identity Development Among Korean Transnational Adoptees: A Relational Dialectics Approach

This study contributes to the literature on transracial adoptions in two important ways: (1) it compares how parents and transnational adoptees negotiate racial and family identities through the use of heritage camps and (2) it informs that comparison with insights garnered from the theory of relational dialectics. The results, which are based on interviews with Korean-born children and Caucasian-American parents (matched parent-child pairs), suggest that parents utilized camps to both downplay their children's racial differences and give credence to their children's “unique” lives. Adoptees, in contrast, were not concerned with downplaying race; instead, they reported that although camps were fun, they did not impact their sense of identity significantly because they did not do enough to address the racial challenges they faced. These results suggest a potential disjuncture between parental purposes for utilizing heritage camps and the actual experiences of adoptees while at these camps. Moreover, they suggest that additional empirical attention should be paid to adoption policies and practices that explicitly address the racial and ethnic needs of transnational adoptees.     

Properties of the sociolinguistic monitor1

This paper investigates the perceptual aspect of quantitative sociolinguistic variation in order to derive properties of a sociolinguistic monitor integrated into linguistic processing in real time. A series of experiments measured listeners’ sensitivity to frequencies in the form of variable percentages of the non‐standard apical form of the variable (ING). Subjects heard ten trial readings of broadcast news from the same speaker, and rated them on a seven‐point Likert scale of professional suitability. Responses conformed closely to a logarithmic function in which the effect of each deviation from the norm was proportional to the percent increase in deviations. The logarithmic pattern of responses was replicated in group and individual experiments in Philadelphia, Pennsylvania, and in group experiments in Columbia, South Carolina and Durham, New Hampshire. South Carolina subjects were less critical of the /in/ variant in news broadcasting but showed the identical logarithmic function in reacting to Northern and Southern speakers. Inferences are drawn on the window of temporal resolution of the sociolinguistic monitor, its sensitivity and the pattern of attenuation over time.     

旅游地居民对旅游业发展认知及影响因素研究

方差分析结果表明,居民的年龄、月收入、受教育程度均影响了居民对旅游业发展所持的态度。典型相关分析的结果显示,居民对旅游业发展带来正面影响的认知与支持旅游业发展之间存在正相关关系。但研究也发现,居民对旅游业发展带来负面影响的认知与居民支持旅游业发展之间不存在显著相关关系。     

Measuring the influence of built neighborhood environments on walking in older adults

There is a need for greater understanding of how perceptions and objective measures of the physical environment influence physical activity among seniors. The goal of this study was to examine the degree of association between perceived and objective characteristics of the neighborhood environment and the relation of each type of measurement to neighborhood walking in older adults. Data on self-reported frequency of walking in the neighborhood and perceived measures of neighborhood environment from 105 older adults were linked to objective measures assessed by geographic information systems and an audit instrument. Perceived and objective measurements of the built environment exhibited a low degree of agreement (kappas: <.20). After adjustment for education, age, and gender, presence of a mall was positively associated with neighborhood walking in both the objective and perceived models.