Analysis of a factorial quantal response assay using inverse regression

An inverse regression approach to analyzing quantal response assays with one quanritative independent- variable and any number of qualitative independent variables is presented. A general factorial model ror LQC- inverted relationship and methods of testing hypotheses estimating qulitative Interest are developed. This naper provides a modified method of analysis which is easier to apply than previously existing methods.     

Asymptotic distribution of regression type estimators of parameters of stable laws

Asymptotic distributions of regression-type estimators for the parameters of stable distributions am obtained. The asymptotic normalized standard deviations of the estimators are computed for various values of the parameters and various choices of the number of points used in getting the regression estimates.     

Age-period-cohort analysis: an illustration of the problems in assessing interaction in one observation per cell data

This paper discusses the specific problems of age-period-cohort (A-P-C) analysis within the general framework of interaction assessment for two-way cross-classified data with one observation per cell. The A-P-C multiple classification model containing the effects of age groups (rows), periods of observation (columns), and birth cohorts (diagonals of the two-way table) is characterized as one of a special class of models involving interaction terms assumed to have very specific forms. The so-called A-P-C identification problem, which results from the use of a particular interaction structure for detecting cohort effects, is shown to manifest itself in the form of an exact linear dependency among the columns of the design matrix. The precise relationship holding among these columns is derived, as is an explicit formula for the bias in the parameter estimates resulting from an incorrect specification of an assumed restriction on the parameters required to solve the normal equations. Current methods for modeling A-P-C data are critically reviewed, an illustrative numerical example is presented, and one potentially promising analysis strategy is discussed. However, gien the large number of possible sources for error in A-P-C analyses, it is strongly recommended that the results of such analyses be interpreted with a great deal of caution.     

The asymptotic distribution of a pivotal quantity for a capture-recapture model

A pivotal quantity for a capture-recapture model is introduced and used to construct an asymptotic confidence region for (ε,N), where ε is the capture efficiency and N is the population size. The true confidence levels of certain regions are obtained by simulation. Certain confidence regions for (ε,N) are drawn to show the size of the regions and to show how confidence limits for N depend on ε.     

Asymptotocally nonparametric tests with censored paired data

A class of asymptotically nonparametric test with contains a test proposed by Wei(1980), is considered for testing the equality of two continuous distribution funcitons when paired observations are subject to arbitrary right censorship. It is shown that under the null hypothesis each test statistic converges in distribution to the standard normal random variable. Furthermore. the Monte Carlo simulation results indicate that some tests in this class are more powerful than Wei's test. A generalization to incomplete censored paired data is also included.     

Bayesian shrinkage estimates for regression coefficients in m populations

For a linear regression model over m populations with separate regression coefficients but a common error variance, a Bayesian model is employed to obtain regression coefficient estimates which are shrunk toward an overall value. The formulation uses Normal priors on the coefficients and diffuse priors on the grand mean vectors, the error variance, and the between-to-error variance ratios. The posterior density of the parameters which were given diffuse priors is obtained. From this the posterior means and variances of regression coefficients and the predictive mean and variance of a future observation are obtained directly by numerical integration in the balanced case, and with the aid of series expansions in the approximately balanced case. An example is presented and worked out for the case of one predictor variable. The method is an extension of Box & Tiao's Bayesian estimation of means in the balanced one-way random effects model.     

On a nonparametric test for the mixed-model

Nonparametric tests for the null hypothesis of no treatment effect in the mixed-model experiment which involves n randomly chosen subjects who respond once to each of ρ distinct treatments have been developed by Koch and Sen (1968), These tests were based on the assumption of compound symmetry of the error vectors and on the weaker assumption of diagonal symmetry of the error vectors. This paper considers an alternative (permutationally) distribution-free test under this latter assumption. The new test follows the same type of distribution theory as those in Koch and Sen, but utilizes the inherent invariance structure in a more visable and direct way.     

Optimum spacings for the joint estimation and tests of hypothesis of location and scale parameters of the cauchy distribution

A simultaneous test for the location and scale parameters of the Cauchy distribution is considered based on selected order statistics.. It is shown that optimum spacings that maximise the Pitman ARE of the test coincide with that of the optimum spacings for the estimation problem.     

Screening procedures using quadratic forms

In quality control, a performance variable having a two-sided specification limit is common for assessing lot quality. Sometimes it is difficult or impossible to measure the performance variable directly; for example, when testing is destructive, expensive, or when the performance variable is related to the lifetime of the product. However, it may happen that there are several concomitant variables which are easily measured and which correlate highly with the variable of interest. Thus, one may use measurements on these variables to select or screen product which will have a high conditional probability of meeting product specification. We consider this situation when all variables have a joint multivariate normal distribution and the specification limits on the performance variable are two-sided.