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Bayesian predictive power: choice of prior and some recommendations for its use as probability of success in drug development 下载免费PDF全文
Bayesian predictive power, the expectation of the power function with respect to a prior distribution for the true underlying effect size, is routinely used in drug development to quantify the probability of success of a clinical trial. Choosing the prior is crucial for the properties and interpretability of Bayesian predictive power. We review recommendations on the choice of prior for Bayesian predictive power and explore its features as a function of the prior. The density of power values induced by a given prior is derived analytically and its shape characterized. We find that for a typical clinical trial scenario, this density has a u‐shape very similar, but not equal, to a β‐distribution. Alternative priors are discussed, and practical recommendations to assess the sensitivity of Bayesian predictive power to its input parameters are provided. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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The paper focuses on the solution business. Here we argue that the strategy can only lead a company to perform better if it encompasses a direct and positive effect on satisfaction with a supplier’s consulting capabilities. Hence we introduce the concept of consulting satisfaction, identify antecedents and analyze its consequences. To do so, we apply a mixed-methods approach. Content analysis from open interviews with company professionals yields a list of antecedents of consulting satisfaction used to devise a set of hypotheses. The latter was translated into a questionnaire based measurement instrument in order to first collect and then analyze data from a larger sample survey. Since three of the antecedents could not be supported by our study, possible explanations are presented. With our approach we tap new dimensions of solutions research. First, we inaugurate research on buying behavior within the field of solutions. Second, we stress the role of capabilities in this field and extend service–profit chain thinking. And third, we present consulting satisfaction as a lever to translate the S-D logic of marketing into more practical applications. To our knowledge this is a novel insight and can help industry decision makers better prepare for the solution business. 相似文献
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In SSR 40 (3), we proposed two new measures for happiness inequality, which have spurred a debate. With this rebuttal we disprove the arguments of our critics and demonstrate that our recommended measure, the percent-maximum standard deviation, is a valuable tool for cross-national comparative research. 相似文献
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Ulrich Steger Christoph Nedopil 《经理人》2007,(9):88-89
由于公司丑司的不断出现,许多国家都加强了公司治理的力度,其中一个方面就是要求公司用一种正确而透明的方式来处理董事会成员们身上的利益冲突问题。 相似文献
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ABSTRACTThe ecological crisis has intensified in many respects. Prominent proposals to deal with the crisis are discussed under the header ‘sustainability transformations’ or even ‘Great Transformation’. We argue that most contributions suffer from a narrow analytical approach to transformation ignoring the largely unsustainable dynamics of global capitalism and the power relations involved in it. Thus, a ‘new critical orthodoxy’ of knowledge about transformation is emerging which runs the danger to contribute to a spatially and socially highly uneven green capitalism. This article claims that the current debate on social-ecological transformation can be enriched by a Polanyian understanding but also based on regulation theory. We distinguish between three types of transformation: incremental adaptation of the current institutional systems, institutional change in favour of a new ‘green’ phase of capitalism, and a post-capitalist great transformation that implies a profound structural change of the mode of production and living. 相似文献
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We examine the relationship between preferences for the public funding of school children day care and the share of foreign pupils in German jurisdictions. To this end, we employ multilevel models to analyze individual-level data from the 1997 and 2002 waves of the German Socio-Economic Panel and data on different jurisdiction-levels from official sources. In contrast to a number of recent studies that investigate the link between redistributive preferences and immigration, we find no evidence for a negative association between the two variables. The specifications either indicate no relationship or a weak positive relationship. Our analysis supports two main conclusions: First, the direction of the relationship between redistributive preferences and immigration depends on the specific domain of the welfare state. Second, we demonstrate that the magnitude of the relationship differs across the different levels of jurisdictions. This second result suggests that the patterns found in the previous literature may not be robust to a disaggregation of the data to lower level of jurisdictions. Further research is necessary once more data is available. 相似文献