Efficacy of newer medications for lower urinary tract symptoms attributed to benign prostatic hyperplasia: a systematic review

We conducted a systematic review to evaluate the efficacy and adverse effects of newer drugs used to treat lower urinary tract symptoms (LUTS). The drugs were either Food and Drug Administration (FDA) approved for benign prostatic hyperplasia (BPH) or not FDA approved for BPH but have been evaluated for treatment of BPH since 2008. We searched bibliographic databases through September 2017. We included randomized controlled trials (RCTs) lasting one month or longer published in English. Outcomes of interest were LUTS assessed by validated measures. Efficacy was interpreted using established thresholds indicating clinical significance that identified the minimal detectable difference. Twenty-three unique, generally short-term, RCTs evaluating over 9000 participants were identified. Alpha-blocker silodosin and phosphodiesterase type 5 inhibitor tadalafil were more effective than placebo in improving LUTS (moderate strength evidence) but these drugs had more adverse effects, including abnormal ejaculation (silodosin). Anticholinergics were only effective versus placebo when combined with an alpha-blocker. Evidence was generally low strength or insufficient for other drugs. Evidence was insufficient to assess long-term efficacy, prevention of symptom progression, need for surgical intervention, or long-term adverse effects. Longer trials are needed to assess the effect of these therapies on response rates using established minimal detectable difference thresholds, disease progression, and harms.     

Strangers are friends I haven't met yet: a positive approach to young people's use of social media

This article reports on a recent research project undertaken in the UK that investigated young people's use of a range of prominent social media tools for socialising and relationship building. The research was conducted by a way of online survey. The findings suggest that this sample of British young people's socialising and relationship-building practices via the range of prominent social media tools reflect similar behavioural categories used offline. The use of these social media tools provides young people with an opportunity to manage, simultaneously, different categories of relationships in a multiplicity of ‘spaces’ created by these tools. The findings challenge the widely held belief that young people expose themselves to risk on social media as they indiscriminately befriend strangers. There is an absence of evidence of ‘unjustified’ intent to harm others. Indeed the findings indicate a strong desire to primarily support and protect those with whom relationships have been carefully established. The research suggests in fact that online engagement through social media can be positive and constructive for young people. It appears to provide them with a challenging ‘space’ to practice identity and relationship management strategies.     

Impaired Probability Estimation and Decision-Making in Pathological Gambling Poker Players

Poker has gained tremendous popularity in recent years, increasing the risk for some individuals to develop pathological gambling. Here, we investigated cognitive biases in a computerized two-player poker task against a fictive opponent, among 12 pathological gambling poker players (PGP), 10 experienced poker players (ExP), and 11 inexperienced poker players (InP). Players were compared on probability estimation and decision-making with the hypothesis that ExP would have significantly lower cognitive biases than PGP and InP, and that the groups could be differentiated based on their cognitive bias styles. The results showed that ExP had a significantly lower average error margin in probability estimation than PGP and InP, and that PGP played hands with lower winning probability than ExP. Binomial logistic regression showed perfect differentiation (100%) between ExP and PGP, and 90.5% classification accuracy between ExP and InP. Multinomial logistic regression showed an overall classification accuracy of 23 out of 33 (69.7%) between the three groups. The classification accuracy of ExP was higher than that of PGP and InP due to the similarities in probability estimation and decision-making between PGP and InP. These impairments in probability estimation and decision-making of PGP may have implications for assessment and treatment of cognitive biases in pathological gambling poker players.     

Assessing Multidimensional Approaches to Measure Program Outcomes in Human Service Organizations

VOLUNTAS: International Journal of Voluntary and Nonprofit Organizations - This study explores scholars’ approaches to measure performance in nonprofit human service organizations. While...     

Ideologies and Forms of Domination in the Organization of the Global Production and Consumption of Goods in the Emerging Postmodern Era: A Case Study of Nike Corporation and the Implications for Gender

This paper uses a case study of Nike Corporation to examine some of the contradictory gender-based ideologies involved in the two main processes of the production and consumption of athletic footwear: manufacturing and advertising. It uses the newly developing paradigm within world-system theory, a commodity chain analysis, to compare and contrast the social relations of gender within each of these two segments at both the micro- and macro-level. Noting the increasing importance of advertising and consumption patterns accompanying emerging post-industrial, postmodern trends, this paper highlights the need for political economy analyses to address more cautiously cultural, political and social factors involved in the production and consumption of goods. This study employs an exploratory approach, using gender as a variable to detect linkages between the economic and cultural realms at the individual and global level. Drawing on some of the post-Marxist literature, it points to new potential for alliances in forging social change. The main attempt is to expand upon development theory which tends to neglect the role of gender, while also expanding studies of gender by investigating gender issues within the framework of the global political economy.     

Money in remarriage: keeping things simple – and separate

This paper investigates money matters in remarried couples. The number of such couples is on the increase, and their financial affairs are likely to be more complex and conflictual than for first-married couples, but there has been little research attention paid to this group in Britain. The present study explores patterns of control and management of money by means of data from semi-structured interviews with 20 couples in which one partner or both had been married before. The men and women were interviewed separately, but in the majority of cases, simultaneously, in separate rooms. This yielded data from 38 interviews since two men declined to take part in the study. Ages of respondents ranged from 28 to 83, with the majority in the 30–55 range. At the time of the study, only half still had dependent children, and not all of the latter were co-resident. A key finding of the study is a degree of separateness in financial arrangements that is in sharp contrast to earlier findings. As many as half of the couples were using an Independent Management system, compared with less than 2 per cent of couples in general. For those with children from previous relationships, this separateness was especially marked in the way they wished their assets to be treated after their death. However, in line with earlier studies, the balance of economic power in second and subsequent marriages still appeared to favour the men, who generally had larger incomes and owned more assets in their own names.     

The many faces of sociology: Ambivalence and conflict in graduate education

This article addresses how the ambivalence of the discipline of sociology affects students’ understanding of it. We consider this ambivalence as multi-layered. The first level embodies the usefulness of sociology as a discipline and sociologists’ ambivalence toward their profession. The second involves applying a sociological perspective to our everyday lives. We discuss the administrative organization of our department, the examination structure, and the structure of asymetric power relations. We conclude that one possible solution toward resolving ambivalences both in our everyday lives and within the profession is to take our critical theoretical training seriously. with special interests in social psychology and qualitative research. She is planning a dissertation on how ideology affects the structure of battered women’s shelters. Barbara G. Brents is a Ph.D. candidate at the University of Missouri with special interests in political economy and aging. She currently is working on a dissertation entitled “The Class Politics of Age: The Social Security Act of 1935.”     

Gambling: The shaping of an opinion

Examining historical and contemporary writings, the authors show that many of the negative arguments about gambling spring from selfish interests in the business and political sectors. The stigma associated with gambling turns out to be a method of preventing competition from gambling, and leads to misguided social policies.The authors are, respectively, associate professor of economics at the Business School of the University of Montreal (HEC), and professor of economics in the department of economics of the University of Montreal. The paper draws on our recently published bookGambling and Speculation (Cambridge University Press, 1990), as well as on events that took place since we finished writing it. We thank Loto-Québec for its financial support.