What Human Capital,Which Migrants? Returned Skilled Migration to Slovakia From the UK1

This article contributes to the understanding of skilled labor migration by exploring some of the differences in the economic behavior of three contrasting groups of returned skilled labor migrants from Slovakia to the United Kingdom: professionals and managers; students; and au pairs. Formal professional experiences and training provide only limited understanding of the value of working/studying abroad. Instead, there is a need to look at particular competences, such as interpersonal skills and self‐confidence, as well as the role of social recognition. The empirical results also emphasize the importance of spatiality and temporality when analyzing skilled labor migration.     

Implementation of an adaptive group sequential design in a bioequivalence study

The study design was a multi-center, multiple-dose, randomized, open-label, 2 x 2 crossover study in patients with advanced solid tumors. Each patient was randomized to receive the test formulation or the reference formulation of the drug. The primary objective of the study was to demonstrate the bioequivalence of the test formulation T relative to the reference formulation R. The primary pharmacokinetic endpoints were AUC and Cmax. Since there were different bioequivalence criteria, different endpoints, with different and highly variable coefficients of variation, an adaptive design with a stopping rule for early establishing the bioequivalence as well as early stopping for futility with a flexible information-based monitoring based on error spending approach was implemented to manage uncertainty in assumptions of variability and expected slow enrollment rates.     

Truncated cross-sectional average length of life: A measure for comparing the mortality history of cohorts

Period life expectancies are commonly used to compare populations, but these correspond to simple juxtapositions of current mortality levels. In order to construct life expectancies for cohorts, a complete historical series of mortality rates is needed, and these are available for only a subset of developed countries. The truncated cross-sectional average length of life (TCAL) is a new measure that captures historical information about all cohorts present at a given moment and is not limited to countries with complete cohort mortality data. The value of TCAL depends on the rates used to complete the cohort series, but differences between TCALs of two populations remain similar irrespective of the data used to complete the cohort series. This result is illustrated by a comparison of TCALs for the US with those for Denmark, Japan, and other high-longevity countries. Specific cohorts that account for most of the disparity in mortality between the populations are identified.

Supplementary material for this article is available at: http://dx.doi.org/10.1080/00324728.2015.1019955     

On Infinitely Divisible Exponential Dispersion Model Related to Poisson-Exponential Distribution

We construct a univariate exponential dispersion model comprised of discrete infinitely divisible distributions. This model emerges in the theory of branching processes. We obtain a representation for the Lévy measure of relevant distributions and characterize their laws as Poisson mixtures and/or compound Poisson distributions. The regularity of the unit variance function of this model is employed for the derivation of approximations by the Poisson-exponential model. We emphasize the role of the latter class. We construct local approximations relating them to properties of special functions and branching diffusions.     

Randomized heuristic algorithms for orthogonal projection of a point onto a set

Abstract

The problem of orthogonal projection of a point onto a set is an essential problem of computational geometry. This problem has many practical applications in different areas such as robotics, computer graphics and so on. In the present paper three algorithms for solving this problem are proposed. This algorithms are based on the idea of heuristic random search. Numerical experiments illustrating the work of the proposed methods are presented.     

A bivariate Bayesian dose‐finding procedure applied to a seamless phase I/II trial in rheumatoid arthritis

We describe a dose escalation procedure for a combined phase I/II clinical trial. The procedure is based on a Bayesian model for the joint distribution of the occurrence of a dose limiting event and of some indicator of efficacy (both considered binary variables), making no assumptions other than monotonicity. Thus, the chances of each outcome are assumed to be non‐decreasing in dose level. We applied the procedure to the design of a placebo‐controlled, sequential trial in rheumatoid arthritis, in each stage of which patients were randomized between placebo and all dose levels that currently appeared safe and non‐futile. On the basis of data from a pilot study, we constructed five different scenarios for the dose–response relationships under which we simulated the trial and assessed the performance of the procedure. The new design appears to have satisfactory operating characteristics and can be adapted to the requirements of a range of trial situations. Copyright © 2012 John Wiley & Sons, Ltd.     

A stochastic process approach to multilayer neutron detectors

The sparsity of the isotope Helium‐3, ongoing since 2009, has initiated a new generation of neutron detectors. One particularly promising development line for detectors is the multilayer gaseous detector. In this paper, a stochastic process approach is used to determine the neutron energy from the additional data afforded by the multilayer nature of these novel detectors. The data from a multilayer detector consist of counts of the number of absorbed neutrons along the sequence of the detector's layers, in which the neutron absorption probability is unknown. We study the maximum likelihood estimator for the intensity and absorption probability and show its consistency and asymptotic normality, as the number of incoming neutrons goes to infinity. We combine these results with known results on the relation between the absorption probability and the wavelength to derive an estimator of the wavelength and to show its consistency and asymptotic normality.     

Doubling Up or Moving Out? The Effect of International Labor Migration on Household Size

We use household panel data from Tajikistan to explore the change in living arrangements as a response to income shifts related to international labour migration. In addition, we analyse the interaction between the effect of idiosyncratic income increase resulting from a completed migration episode, and the effect of an aggregate shock – the global financial crisis – and show how different households adjust their household size during times of financial hardship. The empirical evidence indicates that while current migration is associated with an increase in household size, a completed migration episode two years before the interview was followed by family members moving out. At the same time, our empirical analysis demonstrates that migrant families doubled up in response to a financial crisis to the same extent as non-migrant families, which suggests that labour migration in Tajikistan does not insure against economic shocks in the long run.     

Proposed best practice for projects that involve modelling and simulation

Modelling and simulation has been used in many ways when developing new treatments. To be useful and credible, it is generally agreed that modelling and simulation should be undertaken according to some kind of best practice. A number of authors have suggested elements required for best practice in modelling and simulation. Elements that have been suggested include the pre‐specification of goals, assumptions, methods, and outputs. However, a project that involves modelling and simulation could be simple or complex and could be of relatively low or high importance to the project. It has been argued that the level of detail and the strictness of pre‐specification should be allowed to vary, depending on the complexity and importance of the project. This best practice document does not prescribe how to develop a statistical model. Rather, it describes the elements required for the specification of a project and requires that the practitioner justify in the specification the omission of any of the elements and, in addition, justify the level of detail provided about each element. This document is an initiative of the Special Interest Group for modelling and simulation. The Special Interest Group for modelling and simulation is a body open to members of Statisticians in the Pharmaceutical Industry and the European Federation of Statisticians in the Pharmaceutical Industry. Examples of a very detailed specification and a less detailed specification are included as appendices.