Additional results for 'Sequential design approaches for bioequivalence studies with crossover designs'

In 2008, this group published a paper on approaches for two‐stage crossover bioequivalence (BE) studies that allowed for the reestimation of the second‐stage sample size based on the variance estimated from the first‐stage results. The sequential methods considered used an assumed GMR of 0.95 as part of the method for determining power and sample size. This note adds results for an assumed GMR = 0.90. Two of the methods recommended for GMR = 0.95 in the earlier paper have some unacceptable increases in Type I error rate when the GMR is changed to 0.90. If a sponsor wants to assume 0.90 for the GMR, Method D is recommended. Copyright © 2011 John Wiley & Sons, Ltd.     

Rediscovering the social question

Neoliberal policies not only privatise formerly public services but also focus one-sidedly on discourses of individual autonomy and responsibility. This makes it difficult to raise ‘the social question’ (the question what constitutes social bonds) publicly since market principles are presented as allowing no alternatives. Social work owes its professional origins however to a shift from early capitalist individualism to policies recognising the need for social reconstruction and cohesion. It was mandated to reconcile the key principles of modernity, personal freedom and equality, although its methodology, often corresponding with social policy regimes, interpreted this mandate variably. Attempts in current social work to adjust to the cancellation of the social question through techniques of ‘activation’ and individualised care further the crisis of the project of modernity which manifests itself in a split between heightened public control measures and privatised concerns for ‘care’, thereby altering its core identity. Reflections on social work's historical position within varying political contexts help to promote a renewed critical examination of the profession's political role and highlight the need to turn interventions at the personal level into occasions that affirm social citizenship, ensure rights and promote social equality.     

Toward a Libertarian Theory of Evictionism

There are not two but rather three views regarding the issue of abortion. The first two, pro life and pro choice, are well known. The present paper is dedicated to an elucidation of the third, evictionism. In this perspective, the pregnant woman is allowed to evict her unwanted fetus, but, if it is viable outside of the womb, she is not legally permitted, also, to put it to death, as would apply to abortion. In other words, abortion combines two very different acts, eviction and murder, and only the former is licit, under libertarian law.     

Top Management Team Members’ Decision Influence and Cooperative Behaviour: An Empirical Study in the Information Technology Industry

Organizational leadership is generally distributed between the chief executive officer (CEO) and the top management team (TMT) members. Building on this observation, we present an empirical investigation of the cues for CEOs to delegate decision‐making influence to particular TMT members. In the literature, explanations both based on expertise and driven by similarity are described. In this study, we reconcile both explanations by examining the moderating role of the TMT's level of ‘cooperative behaviour’ (collaboration and information exchange). We analyse when and in what circumstances TMT members’ expertise and similarity to the CEO regarding his/her functional background and/or locus‐of‐control predict their decision‐making influence. We postulate that TMT cooperative behaviour will advance the effect of expertise on TMT members’ decision influence but impede the effect of similarity to the CEO. Our hypotheses are tested on a data set of 135 TMT members from 32 Dutch and Belgian information technology firms. Overall, we find that our proposed research model is confirmed for technology‐oriented decisions. Furthermore, we draw exploratory conclusions about the effect of TMT cooperative behaviour on the systematic distribution of decision influence in TMTs.     

Every Choice Function Is Backwards‐Induction Rationalizable

A choice function is backwards‐induction rationalizable if there exists a finite perfect‐information extensive‐form game such that for each subset of alternatives, the backwards‐induction outcome of the restriction of the game to that subset of alternatives coincides with the choice from that subset. We prove that every choice function is backwards‐induction rationalizable.     

Content Analysis of CDQ From 1994–2003: Implications and Trends for Practitioners and Researchers From a Decade of Research

A review of the content of The Career Development Quarterly (CDQ) was conducted for the period between 1994 and 2003. In total, 297 articles were published in CDQ during this period. The content analysis was based on content, authorship, and institutional affiliation. The principal areas of research were career development: life‐span perspectives and women's workforce participation. Of the articles published during this period, 33% fell into 1 of these 2 categories. Compared with the previous analysis (W. Buboltz & M. Savickas, 1994), a change was noted in the amount of research in women's workforce participation, which rose from 1.4% to 12.8%, whereas research on career development interventions fell by approximately 50%. The authors discuss implications and areas for future research.     

Modifications of the Bonferroni-Holm procedure for a multi-way ANOVA

We present step-wise test procedures based on the Bonferroni-Holm principle for multi-way ANOVA-type models. It is shown for two plausible modifications that the multiple level α is preserved. These theoretical results are supplemented by a simulation study, in a two-way ANOVA setting, to compare the multiple procedures with respect to their simultaneous power and the relative frequency of correctly rejected false hypotheses. Financial support of the Deutsche Forschungsgemeinschaft is gratefully acknowledged.     

On Property and Exploitation

The authors contend that what can legitimately be owned in a free society is only rights to physical property, not to the value thereof. You are thus free to undermine the value of our property by underselling us, by inventing a new substitute for our property, etc. But you cannot legitimately physically agress against our property, even if its value remains constant despite your efforts. This revised version was published online in July 2006 with corrections to the Cover Date.