Informed consent for research on stored blood and tissue samples: a survey of institutional review board practices

Numerous position papers have outlined informed consent recommendations for the collection, storage, and future use of biological samples; however, there currently is no consensus regarding what kinds of information should be included in consent forms. This study aimed to determine whether institutional review boards (IRBs) vary in their informed consent requirements for research on stored biological samples, and whether any variation observed could be correlated to factors such as volume of work, IRB members' familiarity with ethical issues in genetic research, and IRBs' use of either of two policy guidelines as resources. A brief survey was mailed to all IRB chairpersons on a mailing list obtained from the Office for Human Research Protections. Survey questions included whether consent forms for the collection of biological samples for future use address each of six provisions recommended in current guidelines and position statements, and whether IRBs used the Office for Protection from Research Risks' 1993 Protecting Human Research Subjects: Institutional Review Board Guidebook, chapter 5 (hereinafter IRB Guidebook) or the National Bioethics Advisory Commission's 1999 Research Involving Human Biological Materials: Ethical Issues and Policy Guidance, Volume I (hereinafter Report) in their deliberations. Despite a low response rate (22%, 427 respondents), results indicate that IRB practices vary substantially. The degree to which the provisions were included in consent forms was found to correlate positively with IRBs that review a greater volume of protocols annually, those that use the National Bioethics Advisory Commission Report in their deliberations, and those that draw on both the Report and the IRB Guidebook.     

The Relationship of Adaptive and Maladaptive Behaviour to Social Outcomes for Individuals with Developmental Disabilities

The purpose of this study is to examine social outcomes including social interaction opportunities and self-expression, and how they relate to other quality of life indicators. These indicators include the overall assessment of adaptive skills, and the frequency and severity of challenging behaviour. The social interaction opportunities measured in this research include family contact, hours of habilitation, community outings, hours of employment and hours of education. Self-expression refers to the extent to which the individuals assessed indicated liking and choosing what they do in their everyday lives. The data utilised in this study were obtained from personal interviews from 3781 individuals with developmental disabilities and their caregivers. Interviewers received extensive training prior to conducting the assessments. The results indicate that people with higher adaptive ability had more contact with their families, received fewer hours of habilitation, were reported to participate in community outings more frequently, worked more hours and spent fewer hours in education. These significant correlations, however, were of marginal strength. Overall, the frequency and severity of challenging behaviour were not associated with the social interaction opportunities assessed in this study.     

Mastery, Frequency, and Interaction of Managerial Behaviors Relative to Subunit Effectiveness

The relationships among mastery and frequency ofmanagerial behaviors, and subunit effectiveness havefrequently been confused. This study investigates bothmain and interactive effects. The results show that the interaction effect can often be thestrongest effect and that increasing frequency withoutimproving mastery can sometimes be detrimental.Furthermore, these results offer a possible explanation as to why research of managerial behavior hasbeen so inconclusive. In addition, the results questionpopular advice given often to managers. Finally, somerecommendations are made as to how management development could be made more effective basedon the results of this study.     

The Evolution of Organizations: Suggestions from Complexity Theory About the Interplay Between Natural Selection and Adaptation

There has been much debate in the managementliterature between neo-Darwinists (who believe in thenatural selection of populations of organizations) andadaptationists (who contend that changes in organization structure and behavior occur in response to theenvironment). The general thesis of neo-Darwinism isthat species are blindly selected for survival by theenvironment. The latest empirical support for the dominant neo-Darwinism perspective adopted bymost biologists is based primarily on the experimentsconducted by Salvador Luria who claims to haveconclusively demonstrated that genes mutate randomly.Recently, however, biologists have re-examined Luria sresearch methods and, after replications of hisexperiments, now question some aspects of the validityof his results. Moreover, there is now new researchwhich provides support for the earlier adaptationistposition, namely, the existence of evolutionary driversand directors existing within self-organizing systems.Of particular importance to the present study is the experimental indication thatself-organizing systems play a conscious role in theirown evolution. We propose that similar mechanisms orprocesses operate in organizational adaptation, thuspointing toward a theoretical modification ofneo-Darwinism that embraces both adaptation and naturalselection in a general, unified theory.     

Reliance on sources of information for water-saving practices by irrigators in the High Plains of the U.S.A.

Who do farmers trust? Irrigators in the High Plains are confronted with a wide range of information sources with respect to water-saving practices. From a survey of 709 irrigators in 10 countries the most widely accepted sources are identified, regional variability of information is examined, the role of irrigator characteristics on source selection is determined, and the level of association between adoption and source preference is analyzed. Differences in irrigators' reliance on specific sources are more associated with location than irrigator characteristics. Information sources viewed as important by many irrigators frequently influence adoption decisions less than sources having a wide range of preference among irrigators. Mass media and advisor-oriented sources are much more significantly linked to adoption than inter-personal sources such as friends and neighbors. The three sources that best discriminate adoption behavior are private agricultural consulting firms, university research stations, and trade magazines.     

EXAMINING THE MULTIFACETED NOTION OF ISOMORPHISM IN MARRIAGE AND FAMILY THERAPY SUPERVISION: A QUEST FOR CONCEPTUAL CLARITY

The notion of isomorphism has been recommended as a comceptual framework to guide the practice of marrige and family therapy (MFT) supervision. The term is frequently cited in the MFT training literature but is often used in different ways. A panel of MFT supervirors rated the impotance and relevance to both therapy and supervision of a large pool of variables. The majority of variables were found to be a equally relevant or isomorphic to the domains of MFT and MFT supervisoin. A qualitative interview with a small subset of the panelists suggested that the concept, to varying degrees, has influenced their work as supervisors. The implications of the results for theory development, research, and supervisory practices are discussed.     

TAXING POLITICAL LIFE:

Previous research has shown that participation in voluntary associations, including those labeled nonpolitical, increases political participation. Using data gathered from 2,517 interviews for the American Citizen Participation Study, we complicate this understanding by exploring the relationship between voluntary association involvement and political activity in a more nuanced manner–separating association involvements according to the level of exposure to political dialogue and information, even within organizations typically considered apolitical. We find that the extent to which association involvement predicts political participation is dependent upon the level of political activity that transpires within these otherwise nonpolitical organizations. In order for participation in voluntary associations to lead to increases in political participation, participants must have exposure to political discourse. It is not the generic act of participation that supports political life but rather the opportunity to engage with politics that serves as an impetus for political activity. In light of this, we offer a critical exploration of existing federal tax policies governing nonprofit organizations.