Simulation-based inference for simultaneous processes on regular lattices

The article proposes a simulation-based inferential method for simultaneous processes defined on a regular lattice. The focus is on spatio-temporal processes with a simultaneous component, that is such that contemporaneous spatial neighbors are potential explanatory variables in the model. The new method has the advantage of being simpler to implement than maximum likelihood and allows us to propose a robust estimator. We give asymptotic properties, present a Monte Carlo study and an illustrative example.     

产品"商家设计"的价值

由于商业经营者的积极参与而导致设计过程与设计方式发生改变,是当前产品设计活动中出现的一个新的现象,即产品设计过程中的“商家设计”现象。“商家设计”活动由特定的市场环境与技术条件所催生,其价值不仅在于能够为产品生产企业、产品营销商和产品用户带来现实的利益,同时还在于拓展了工业设计实践的领域,为工业设计应用方法研究提供了新的空间。     

血管生成素通过ERK信号通路促进HeLa细胞的增殖

目的通过细胞外信号调节激酶（extracellularregulatedproteinkinases,ERK）通路及NF-xB信号途径探讨血管生成素（angiogenin,Ang）对HeLa细胞的促增殖及抗凋亡作用机制。方法用不同浓度的重组人Ang刺激HeLa细胞,MTr法分析Ang对HeLa细胞的促增殖作用,蛋白质印迹实验检测ERK信号通路相关分子的表达情况。U0126抑制ERK信号通路,检测Ang诱导的ERKl／2的磷酸化及c—myc的表达情况,同时检测Ang对细胞增殖的影响。敲低Ang的表达,检测细胞的凋亡情况。双荧光素酶报告基因检测Ang对NF-KB报告基因的激活。蛋白水平检测Ang刺激的HeLa细胞后,NF—KB通路相关分子的表达。结果Ang能促进HeLa细胞增殖,ERKl／2的磷酸化水平及c—myc的表达随重组人Ang浓度的升高而增加。U0126能抑制Ang诱导的ERKI／2的磷酸化、c—myc的上调及细胞的增殖。Ang的低表达促进HeLa细胞的凋亡,但不影响NF-KB报告基因的激活及NF—KB通路上相关分子的表达。结论Ang能够促进HeLa细胞增殖,并通过活化ERK通路促进细胞的增殖,但其抑凋亡作用与NF-KB通路无关。     

A Bayesian cluster analysis of election results

A Bayesian cluster analysis for the results of an election based on multinomial mixture models is proposed. The number of clusters is chosen based on the careful comparison of the results with predictive simulations from the models, and by checking whether models capture most of the spatial dependence in the results. By implementing the analysis on five recent elections in Barcelona, the reader is walked through the choice of the best statistics and graphical displays to help chose a model and present the results. Even though the models do not use any information about the location of the areas in which the results are broken into, in the example they uncover a four-cluster structure with a strong spatial dependence, that is very stable over time and relates to the demographic composition.     

Networks Matter: Male Mexican Migrants’ Use of Hospitals

Using the behavioral model for health care use and unique data from the Mexican migration project, we explore the factors associated with hospital use among Mexican male migrants to the US. Twenty-eight percent of the respondents reported receiving healthcare from a hospital. In addition to established enabling factors of time in the US and English language ability, this research points to the importance of family social networks as enabling hospital health care use among migrants. Migrants with more ties to family members with migration experience have an increased likelihood of using emergency room healthcare. The research adds to the body of literature by providing evidence that ties to individuals with US migration experience increases migrants’ probability of accessing healthcare at hospitals.     

巴塞罗那的设计和创新

设计在巴塞罗那的生活中具有重要作用.在过去的几百年当中,设计是促进巴塞罗那产生创造力的背后推动力. 大约一百年前,我们在巴塞罗那开展了总体设计,比较著名的设计师有高迪以及和他同期的设计师.     

An iterated greedy algorithm for the flowshop scheduling problem with blocking

This paper proposes an iterated greedy algorithm for solving the blocking flowshop scheduling problem for makespan minimization. Moreover, it presents an improved NEH-based heuristic, which is used as the initial solution procedure for the iterated greedy algorithm. The effectiveness of both procedures was tested on some of Taillard’s benchmark instances that are considered to be blocking flowshop instances. The experimental evaluation showed the efficiency of the proposed algorithm, in spite of its simple structure, in comparison with a state-of-the-art algorithm. In addition, new best solutions for Taillard’s instances are reported for this problem, which can be used as a basis of comparison in future studies.     

Too Big to Learn: The Effects of Major Acquisition Failures on Subsequent Acquisition Divestment

We examine whether firms learn from their major acquisition failures. Drawing from a threat‐rigidity theoretical framework, we suggest that firms do not learn from their major acquisition failures. Furthermore, we hypothesize that host‐country experience reinforces the negative effects of major acquisition failures. Our research hypotheses are tested using an event history analysis of 741 acquisitions undertaken by French listed and non‐listed firms in the USA between January 1988 and December 2008. We use failure divestment (divestment resulting from acquisition failure) as a proxy for acquisition performance. Consistent with our theoretical framework, we find that major acquisition failures have a negative impact on future acquisition performance. Furthermore, we find that such negative effects are reinforced by firms’ host‐country experience.