On sequential closed testing dose groups with a control

Methods for a sequential test of a dose-response effect in pre-clinical studies are investigated. The objective of the test procedure is to compare several dose groups with a zero-dose control. The sequential testing is conducted within a closed family of one-sided tests. The procedures investigated are based on a monotonicity assumption. These closed procedures strongly control the familywise error rate while providing information about the shape of the dose-responce relationship. Performance of sequential testing procedures are compared via a Monte Carlo simulation study. We illustrae the procedures by application to a real data set.     

Bimodal skew-symmetric normal distribution

ABSTRACT

We introduce a new parsimonious bimodal distribution, referred to as the bimodal skew-symmetric Normal (BSSN) distribution, which is potentially effective in capturing bimodality, excess kurtosis, and skewness. Explicit expressions for the moment-generating function, mean, variance, skewness, and excess kurtosis were derived. The shape properties of the proposed distribution were investigated in regard to skewness, kurtosis, and bimodality. Maximum likelihood estimation was considered and an expression for the observed information matrix was provided. Illustrative examples using medical and financial data as well as simulated data from a mixture of normal distributions were worked.     

Measures of uniformity in experimental designs: A selective overview

ABSTRACT

Discrepancies are measures which are defined as the deviation between the empirical and the theoretical uniform distribution. In this way, discrepancy is a measure of uniformity which provides a way of construction a special kind of space filling designs, namely uniform designs. Several discrepancies have been proposed in recent literature. A brief, selective review of these measures including some construction algorithms are given in this paper. Furthermore, a critical discussion along with some comparisons is provided, as well.     

A new generalized normal distribution: Properties and applications

Abstract

The most commonly studied generalized normal distribution is the well-known skew-normal by Azzalini. In this paper, a new generalized normal distribution is defined and studied. The distribution is unimodal and it can be skewed right or left. The relationships between the parameters and the mean, variance, skewness, and kurtosis are discussed. It is observed that the new distribution has a much wider range of skewness and kurtosis than the skew-normal distribution. The method of maximum likelihood is proposed to estimate the distribution parameters. Two real data sets are applied to illustrate the flexibility of the distribution.     

A Design of s Control Charts with a Combined Double Sampling and Variable Sampling Interval Scheme

In this paper, we propose new estimation techniques in connection with the system of S-distributions. Besides “exact” maximum likelihood (ML), we propose simulated ML and a characteristic function-based procedure. The “exact” and simulated likelihoods can be used to provide numerical, MCMC-based Bayesian inferences.     

The Scale Invariant Wigner Spectrum Estimation of Gaussian Locally Self-Similar Processes

We study locally self-similar processes (LSSPs) in Silverman’s sense. By deriving the minimum mean-square optimal kernel within Cohen’s class counterpart of time–frequency representations, we obtain an optimal estimation for the scale invariant Wigner spectrum (SIWS) of Gaussian LSSPs. The class of estimators is completely characterized in terms of kernels, so the optimal kernel minimizes the mean-square error of the estimation. We obtain the SIWS estimation for two cases: global and local, where in the local case, the kernel is allowed to vary with time and frequency. We also introduce two generalizations of LSSPs: the locally self-similar chirp process and the multicomponent LSSP, and obtain their optimal kernels. Finally, the performance and accuracy of the estimation is studied via simulation.     

A New Control Scheme Always Better Than X-Bar Chart

A new control scheme is proposed by borrowing the idea of the Benjamini–Hochberg procedure for controlling the false discovery rate in multiple testing. It is shown theoretically that the proposed 2-span control scheme outperforms the Shewhart X-bar chart in terms of the average run length under any size of mean shifts. Some simulations are carried out to demonstrate that the proposed scheme having various span sizes always outperforms the X-bar chart in terms of the average run lengths.     

A generalization of mosteller's test

A generalization of Mosteller's test for slippage of the location parameter is proposed. The distribution of the test statistic under the null hypothesis is obtained and the power of the test is compared with that of Mosteller's test     

Qdf misclassification probabilities for known population parameters

Approximated QDF misclassification probabilities have been derived for bivariate normal populations with known parameter values. Tne effect of unequal covariances and population distance on the misclassification probabilities are examined