Modeling Lung Carcinogenesis in Radon‐Exposed Miner Cohorts: Accounting for Missing Information on Smoking

Epidemiological miner cohort data used to estimate lung cancer risks related to occupational radon exposure often lack cohort‐wide information on exposure to tobacco smoke, a potential confounder and important effect modifier. We have developed a method to project data on smoking habits from a case‐control study onto an entire cohort by means of a Monte Carlo resampling technique. As a proof of principle, this method is tested on a subcohort of 35,084 former uranium miners employed at the WISMUT company (Germany), with 461 lung cancer deaths in the follow‐up period 1955–1998. After applying the proposed imputation technique, a biologically‐based carcinogenesis model is employed to analyze the cohort's lung cancer mortality data. A sensitivity analysis based on a set of 200 independent projections with subsequent model analyses yields narrow distributions of the free model parameters, indicating that parameter values are relatively stable and independent of individual projections. This technique thus offers a possibility to account for unknown smoking habits, enabling us to unravel risks related to radon, to smoking, and to the combination of both.     

The Johnson System of Frequency Curves—Historical,Graphical, and Limiting Perspectives

Abstract

The idea of transforming one random variate to another with a more convenient density has been developed in the first half of the 20th century. In his thesis, Norman L. Johnson (1917–2004) developed a pioneering system of transformations of the standard normal distribution which gained substantial popularity in the second half of the 20th century and beyond. In Johnson’s 1949 Johnson, N. L. (1949), “Systems of Frequency Curves Generated by Methods of Translation,” Biometrika, 36, 149–176.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar] Biometrika paper entitled Systems of frequency curves generated by methods of translation, summarizing that thesis, one of his primary interests was the behavior of the shape of the probability density functions as their parameter values change. Herein, we attempt to further elucidate this behavior through a series of geometric expositions of that transformation process. In these expositions insight is obtained into the behavior of Johnson’s density functions, and their skewness and kurtosis, as they converge to their limiting distributions, a topic which received little attention.     

The snowball effect of customer slowdown in critical many-server systems

Customer slowdown describes the phenomenon that a customer’s service requirement increases with experienced delay. In healthcare settings, there is substantial empirical evidence for slowdown, particularly when a patient’s delay exceeds a certain threshold. For such threshold slowdown situations, we design and analyze a many-server system that leads to a two-dimensional Markov process. Analysis of this system leads to insights into the potentially detrimental effects of slowdown, especially in heavy-traffic conditions. We quantify the consequences of underprovisioning due to neglecting slowdown, demonstrate the presence of a subtle bistable system behavior, and discuss in detail the snowball effect: A delayed customer has an increased service requirement, causing longer delays for other customers, who in turn due to slowdown might require longer service times.     

Dutch Adolescents’ Motives,Perceptions, and Reflections Toward Sex-Related Internet Use: Results of a Web-Based Focus-Group Study

The Internet offers adolescents unique opportunities to actively shape their own sexual media environment. The aim of this study was to gain in-depth insight into Dutch adolescents’ motives, perceptions, and reflections toward Internet use for (a) finding information or advice related to romance and sexuality; (b) searching for and viewing pornographic or erotic material; and (c) romantic and sexual communication (i.e., cybersex/sexting). Data were collected through 12 Web-based focus groups (36 adolescents aged 16 to 19 years, 72.2% girls) and analyzed through three stages of open, axial, and selective coding. The themes that emerged from the focus-group discussions suggest that sex-related Internet use is a complex and ambivalent experience for adolescents. Sex-related Internet use seems an increasingly normalized and common phenomenon. Participants perceived the Internet as a useful source of sexual information, stimulation, inspiration, and communication. Yet they discussed a range of negative consequences and risks related to sex-related online behaviors, particularly concerning pornography’s potential to create unrealistic expectations about sex and sexual attractiveness. Participants generally believed they had the necessary skills to navigate through the online sexual landscape in a responsible way, although they believed other young people could be influenced inadvertently and adversely by sex-related online content.     

Disentangling the Frequency and Severity of Bullying and Victimization in the Association with Empathy

This study disentangled the frequency and perceived severity of experienced bullying and victimization by investigating their associations with cognitive and affective empathy. Participants were 800 children (7–12 years old) from third‐ to fifth‐grade classrooms who completed self‐report measures of the frequency and perceived severity of their bullying and victimization and of cognitive and affective empathy. Results showed that the frequency and perceived severity of bullying were moderately correlated in the entire sample but unrelated within the subsample of bullies. Frequency and perceived severity of victimization were significantly and positively correlated in the entire sample (moderate effect) and the subsample of victims (small effect). Frequent, but not severe, bullies reported less cognitive empathy than non‐bullies whereas both frequent and severe victims reported more affective empathy than non‐victims. Within subsamples of bullies and victims, frequency of bullying was negatively associated with cognitive and affective empathy, and perceived severity of bullying was positively associated with affective empathy. Frequency of victimization was not associated with cognitive and affective empathy, but perceived severity of victimization was positively associated with both forms of empathy.     

Immigrants’ Attitudes toward Homosexuality: Socialization,Religion, and Acculturation in European Host Societies

With increasing diversity of migrants in Europe, questions around cultural integration are gaining importance. This study focuses on attitudes towards homosexuality amongst first and second generation immigrants from 186 origin countries to examine the role of religion, origin country socialization and acculturation. There is clear evidence for intra‐ and intergenerational acculturation of attitudes with declining importance of origin country context. While individual characteristics of migrants and origin country context can explain a substantial part of religious group differences particularly amongst the first generation, Muslims and to a lesser extent other non‐Christian and Eastern Orthodox migrants hold overall more negative attitudes.     

Going All the Way: Politicizing,Polarizing, and Radicalizing Identity Offline and Online

This essay conceptualizes radicalization as a collective process that evolves within the context of global, national, or local intergroup tensions. People do not radicalize on their own, but as part of a group in which a collective identity is developed. Some members of the group may take a radical activist route to promote or prevent social change. Their interactions with their opponents intensify, while their ideas and beliefs sharpen. In this essay, I propose an interpretative framework to analyze radicalizing collective identities. The framework departs from the notion that supranational processes shape and mold the micro level of (radicalizing) citizens' demands, the meso level of social movements and political parties, and the macro level of national political systems. The answer to questions such as who radicalizes, why people radicalize, and the forms radical action takes lies in the interaction of supranational processes, national political processes, and the context of political mobilization. It is argued that radicalizing identities are key in this process, no radicalization without identification!     

Three Wise Young Men,a Cyber Community and Music — Counselling As Social Action: Storying a Community of Care in the Aftermath of Violence

This article describes counselling practice as social action, reporting on a case of children witnessing community violence and its aftermath. Highlighted is the role of friends who made a stand of solidarity against such violence. Outsider witness practices helped recruit and grow a community of care for the client and his friends. This community of care was significantly enhanced by the involvement of a lawyer/musician/activist who composed a song with the three friends to take a stance against guns and violence in their society. Caring solidarity, generosity and doing hope together formed small but significant alliances against entrenched practices of violence.