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701.
Elizabethkingia spp. are common environmental pathogens responsible for infections in more vulnerable populations. Although the exposure routes of concern are not well understood, some hospital-associated outbreaks have indicated possible waterborne transmission. In order to facilitate quantitative microbial risk assessment (QMRA) for Elizabethkingia spp., this study fit dose–response models to frog and mice datasets that evaluated intramuscular and intraperitoneal exposure to Elizabethkingia spp. The frog datasets could be pooled, and the exact beta-Poisson model was the best fitting model with optimized parameters α = 0.52 and β = 86,351. Using the exact beta-Poisson model, the dose of Elizabethkingia miricola resulting in a 50% morbidity response (LD50) was estimated to be approximately 237,000 CFU. The model developed herein was used to estimate the probability of infection for a hospital patient under a modeled exposure scenario involving a contaminated medical device and reported Elizabethkingia spp. concentrations isolated from hospital sinks after an outbreak. The median exposure dose was approximately 3 CFU/insertion event, and the corresponding median risk of infection was 3.4E-05. The median risk estimated in this case study was lower than the 3% attack rate observed in a previous outbreak, however, there are noted gaps pertaining to the possible concentrations of Elizabethkingia spp. in tap water and the most likely exposure routes. This is the first dose–response model developed for Elizabethkingia spp. thus enabling future risk assessments to help determine levels of risk and potential effective risk management strategies. 相似文献
702.
703.
Local labor market supportability is becoming an increasingly important issue for the United States Army Reserves. As military bases close and Reserve units are consolidated at fewer Reserve centers, the appropriate reassignments of units to Reserve centers require accurate measures of the ability of local labor markets to support such consolidations. A two-stage random effect model is applied to evaluate the geographical extent of the labor market for Army Reserve centers. In the first stage model, a lognormal distribution is used to describe the commuting distance behavior of the Reserve center members. In the second stage model, we estimate the mean of log transformed commute distance as a function of regional characteristics of the Reserve center. An iterative weighted stepwise selection method is used to find a set of characteristics that adequately predict variation of the mean commute distance over Reserve centers. The resulting model is used as inputs to location and market assessment models to assist the marketing decisions of the Army Recruiting Command. 相似文献
704.
Variable time work is no longer abnormal in the post-industrial economy and is accelerating due to digitisation and the COVID-19 pandemic. Previous studies have revealed a causal relationship between working time variability and work–life balance at the individual level; however, there has been less discussion of the role of the institutional context. This study examines the interplay among childcare policy, schedule control, and its relationship with work–life balance. We conducted a multilevel analysis using the European Working Conditions Survey. The analyses revealed that childcare policy has a U-shaped relationship with work–life balance for female variable time workers without schedule control. In contrast, workers with schedule control and male workers did not have a curvilinear relationship with the outcome. Our analyses imply that sufficient childcare intervention and its interaction with schedule control are necessary to offset the negative effect of childcare services on work–life balance. 相似文献
705.
706.
Jerald W. Young 《决策科学》1979,10(1):57-61
Three conceptual and methodological issues of the preceding paper by Bonoma and Johnston are identified and discussed. A theoretical integration of interpersonal trust and locus of control is made, and some necessary conditions for an interpersonal trust-relevant decision-making situation are pointed out. Implications for the design of future research into trust-relevant decision making are drawn. 相似文献