Development of predictive signatures for treatment selection in precision medicine with survival outcomes

For survival endpoints in subgroup selection, a score conversion model is often used to convert the set of biomarkers for each patient into a univariate score and using the median of the univariate scores to divide the patients into biomarker‐positive and biomarker‐negative subgroups. However, this may lead to bias in patient subgroup identification regarding the 2 issues: (1) treatment is equally effective for all patients and/or there is no subgroup difference; (2) the median value of the univariate scores as a cutoff may be inappropriate if the sizes of the 2 subgroups are differ substantially. We utilize a univariate composite score method to convert the set of patient's candidate biomarkers to a univariate response score. We propose applying the likelihood ratio test (LRT) to assess homogeneity of the sampled patients to address the first issue. In the context of identification of the subgroup of responders in adaptive design to demonstrate improvement of treatment efficacy (adaptive power), we suggest that subgroup selection is carried out if the LRT is significant. For the second issue, we utilize a likelihood‐based change‐point algorithm to find an optimal cutoff. Our simulation study shows that type I error generally is controlled, while the overall adaptive power to detect treatment effects sacrifices approximately 4.5% for the simulation designs considered by performing the LRT; furthermore, the change‐point algorithm outperforms the median cutoff considerably when the subgroup sizes differ substantially.     

日本漫画翻译技法初探——以特殊表记为中心

如所周知，特殊表记如今已经成为漫画不可或缺的部分。在创作漫画时加入英文表记和外来语表记能够丰富故事内容，使人物形象更为丰满，同时适当使用这些表记能够使漫画更加贴近年轻受众群体。但是在实际翻译漫画时，这些特殊的表记却极易被漫画的译者所忽视。通过从人物对白、特殊用语以及人名三方面入手，从实用角度结合具体案例探讨了日本漫画中英文表记、外来语表记的处理策略，认为应根据特殊表记出现的位置及作用来具体选择翻译方式，不应一概而论。     

构建舟山群岛新区水资源安全保障体系研究

"新区发展水为先",这是舟山发展一贯经验的科学总结。水资源直接影响着舟山群岛新区建设的速度和质量,关系到人民生活水平的提高,对新区发展具有特殊重要的意义。文章在分析舟山群岛新区水源地环境基本状况的基础上,对水资源供求趋势进行了预测和分析,并从完善有偿使用和取水许可制度、建立水资源统一管理体制,完善增加蓄水资源的引导性政策、健全可持续开发利用的激励配套措施,强化水源与供水工程网络建设、优先开发利用好当地水资源阐释了构建舟山群岛新区水资源安全保障体系的对策。     

论“主体建构”的认识论来源及理论意义

本文着力解决的是主体建构在社会科学诸多范式与取向中的合法性问题。主体建构是一种视角、一个解释工具,也是一种方法论取向,同时也可以被理解为一种认识论倾向。主体建构以现象学关于主体意向性与意义建构的论断为认识论基础,以理解社会学为理论源泉,试图理解关于同一社会现象在不同主体的视角下的不同的意义。主体建构的目的是对这些不同的意义进行差异性理解、过程性理解与情境性理解,并以此解构垄断意义与固化意义,寻求社会现象的多元意义。     

基于消费者效用的生鲜农产品供应链生鲜度激励机制研究

生鲜供应链整体生鲜度的提升对减少浪费、提高供应链整体盈利水平及社会福利有重要意义。本文基于消费者效用理论研究了两供应商和单一零售商组成的供应链系统，构建了单周期下生鲜农产品生鲜度激励模型，模型以供应商为领导者，采用Stackelberg博弈方法求解得到了均衡状态下供应商、零售商的最优定价策略及供应商新鲜度努力选择。研究结果表明，供应商和零售商利润与消费者价格敏感系数呈反向变化，与新鲜度敏感系数呈同向变化。在价格竞争市场，供应商保鲜努力程度和利润与价格替代率呈反向变化；在生鲜度竞争市场，供应商保鲜努力程度和利润与新鲜度替代率呈同向变化。基于研究结论，厂商及政府应当联手引导消费者的消费观念，尽可能减少由于信息不对称引致的道德风险，在市场价格替代率不变甚至降低的情形下，提高生鲜度替代率，使得消费者的意愿支付价格上升，提高自身讨价还价能力，获取更多利润。     

Relational Management Mechanisms for Strategic Alliances Among Nonprofit Organizations

This study employs a qualitative multiple-case study to explore relational management mechanisms for strategic nonprofit alliances (NPAs) formed by at least 3 nonprofit organizations by examining collaborative relationships among farmers associations in Taiwan. We explore these mechanisms by analyzing case data from four strategic cooperation characteristics, which can best explain NPAs. To effectively sustain partnerships, our findings suggest that an NPA applies acceptable collaborative rules and regulations, common standard procedures, symmetric information and communication, and capability building and corrective measures when cooperation involves high input commonality. The results also suggest empowerment for partners with deeper input commitment to direct decisions on resource distribution and utilization when collaborative ties involve low input measurability. Regarding high output commonality, we advise NPAs to enforce common output quality control, efficient substandard-output treatment, and external incentives as mechanisms to encourage partners for continued commitment. If relationships involve low output measurability, our findings suggest that NPAs heighten partners’ voluntary motivation for the common good, with goal-achievement assessment measures, professional certification by external experts, and acceptable and reasonable benefit-sharing methods     

论新媒体冲击下纸媒的生存与发展——以报纸为例

互联网的发展、智能手机的普及使传统的传媒环境和格局发生了翻天覆地的变化。新媒体的崛起与壮大给以纸媒为代表的传统媒体带来了前所未有的冲击，但不可否认的是，纸媒自身依然有不可替代的优势。本文主要以报纸为例，从纸媒传播内容的深度和可信度、纸媒对于受众文化素质的要求以及纸媒的表现形式、和受众的互动等方面的特点入手，分析在新媒体的冲击下纸媒所面临的生存现状，并且在此基础上指出将来纸媒应该如何利用新媒体的技术来促进自身的发展，更好地实现新媒体与传统媒体的融合。     

PROVIDING GLOBAL PUBLIC GOODS: ELECTORAL DELEGATION AND COOPERATION

This study experimentally examines the effect of electoral delegation on providing global public goods shared by several groups. Each group elects one delegate who can freely decide on each group member's contribution to the global public goods. Our results show that people mostly vote for delegates who assign equal contributions for every group member. However, in contrast to standard theoretical predictions for our delegation mechanism, unequal contributions across groups drive cooperation down over time, and it decreases efficiency by almost 50% compared to the selfish benchmark. This pattern is not driven by delegates trying to exploit their fellow group members, as indicated by theory. It is driven by conditional cooperation of delegates across groups. Since one of the potential sources of the resulting inefficiency is the polycentric nature of global public goods provision together with other‐regarding preferences, we use the term P‐inefficiency to describe our finding. (JEL C92, D72, H41)     

我国幼儿食育必要性及其促进策略

食育是饮食行为教育，是对孩子进行包括饮食观念、膳食营养知识和饮食卫生安全等一系列营养学的教育。食育的开展是一项利国利民，值得大力推广的事情。食育应当成为全民的教育，且越早开始越好。目前我国食育还处于萌芽阶段，幼儿食育的推进更是任重而道远，需要幼儿园、家庭、政府、社区乃至全社会的共同参与。