On the use of extreme value tail modeling for generalized pairwise comparisons with censored outcomes

In randomized clinical trials, methods of pairwise comparisons such as the ‘Net Benefit’ or the ‘win ratio’ have recently gained much attention when interests lies in assessing the effect of a treatment as compared to a standard of care. Among other advantages, these methods are usually praised for delivering a treatment measure that can easily handle multiple outcomes of different nature, while keeping a meaningful interpretation for patients and clinicians. For time-to-event outcomes, a recent suggestion emerged in the literature for estimating these treatment measures by providing a natural handling of censored outcomes. However, this estimation procedure may lead to biased estimates when tails of survival functions cannot be reliably estimated using Kaplan–Meier estimators. The problem then extrapolates to the other outcomes incorporated in the pairwise comparison construction. In this work, we suggest to extend the procedure by the consideration of a hybrid survival function estimator that relies on an extreme value tail model through the Generalized Pareto distribution. We provide an estimator of treatment effect measures that notably improves on bias and remains easily apprehended for practical implementation. This is illustrated in an extensive simulation study as well as in an actual trial of a new cancer immunotherapy.     

Effects of pushing height on trunk posture and trunk muscle activity when a cart suddenly starts or stops moving

Unexpected sudden (un)loading of the trunk may induce inadequate responses of trunk muscles and uncontrolled trunk motion. These unexpected perturbations may occur in pushing tasks, when the cart suddenly starts moving (unloading) or is blocked by an obstacle (loading). In pushing, handle height affects the user's working posture, which may influence trunk muscle activity and trunk movement in response to the perturbation. Eleven healthy male subjects pushed a 200 kg cart with handles at shoulder and hip height in a start condition (sudden release of brakes) and a stop condition (bumping into an obstacle). Before the perturbation, the baseline of the trunk inclination, internal moment and trunk extensor muscle activity were significantly higher when pushing at hip height than at shoulder height. After the perturbation, the changes in trunk inclination and internal moment were significantly larger when pushing at shoulder height than at hip height in both conditions. The opposite directions of changes in trunk inclination and internal moment suggest that the unexpected perturbations caused uncontrolled trunk motion. Pushing at shoulder height may impose a high risk of low-back injury due to the low trunk stiffness and large involuntary trunk motion occurring after carts suddenly move or stop.     

The type I distribution of the ratio of independent “Weibullized” generalized beta-prime variables

In this paper we introduce the distribution of , with c >  0, where X _i , i =  1, 2, are independent generalized beta-prime-distributed random variables, and establish a closed form expression of its density. This distribution has as its limiting case the generalized beta type I distribution recently introduced by Nadarajah and Kotz (2004). Due to the presence of several parameters the density can take a wide variety of shapes.      

Child Well‐Being: What Does It Mean?

The notion of child well‐being appears in a large number of publications nowadays. Our review of the literature underlines both the oddly pathogenic approach to child well‐being and the scarcity of papers discussing a still poorly defined notion. Through this review, we identified the recourse to a binary language; from there, we derived five theoretical axes that heed the multidimensional and multilevel nature of well‐being, although for each one, a pole is here predominantly developed. We argue in favour of an override of a one‐dimensional, single‐level, unipolar approach to child well‐being and an exploration of its otherwise underdeveloped positive, hedonic, subjective, spiritual and collective dimensions.     

Gender differences in gambling preferences and problem gambling: a network-level analysis

Most gambling studies have a gender-blind research approach, although a large body of scientific evidence suggests that gambling in females is on the rise and that males and females have different gambling behaviours and experience specific gambling-related harm. This study addressed these gender differences using a network analysis, an innovative approach considering disorders/concepts as dynamic systems of interacting symptoms/items. Data on gambling activities, problem gambling, substance use and mental health were collected in a representative sample of French adult gamblers (n = 8805). The study capitalized on the network analysis directly to compare associations of specific gambling activities with gambling disorder symptoms separately for both genders. The network analysis revealed that problem gambling was strongly associated with gambling machines among females, whereas it was related to sports betting, poker and casino games among males. The networks that included substance use and mental health showed that substance use was related to specific gambling activities. These findings confirm the links between various gender-specific gambling patterns and problem gambling and suggest a need to consider these gender differences to improve prevention efforts. More broadly, the present study further supports the importance of gender differences for gambling research and policy.     

Working in partnership: user perceptions of intensive home visiting

The aim of this study was to explore the perceptions of vulnerable women about the value of intensive home visiting in pregnancy and the first year of life delivered by health visitors trained to work in partnership with families. Twenty in‐depth interviews were conducted with women who had completed the home visiting programme and agreed to be interviewed. The data were fully transcribed and analysed thematically. Despite initial concerns and negative preconceptions about health and social service professionals, participating women greatly valued the relationships that were established with their home visitors and identified a number of ways in which they had benefited. These included increased confidence, improved mental health, better parenting, improved relationships and changes in their attitudes toward professionals. These findings demonstrate the potential of intensive home visiting delivered in partnership with mothers in reaching and helping vulnerable and ‘hard‐to‐reach’ families. They highlight the importance of establishing a trusting relationship between helper and provider, and the need for home visitors to have the necessary skills and qualities to establish such relationships. Copyright © 2007 John Wiley & Sons, Ltd.     

Perceived verbal conflict behaviors associated with physical aggression and sexual coercion in dating relationships: a gender-sensitive analysis

We studied perceived partner verbal behaviors associated with participants' use of dating aggression. Men's reports of their partners' demanding, controlling, and psychologically abusive behaviors during conflicts were expected to predict men's perpetration against partners. In contrast, women's reports of their partners' withdrawal were expected to predict women's perpetration. Data were collected from heterosexual undergraduates (N = 223) in exclusive dating relationships. Participants' reports of partner demands and partner psychological abuse were associated with participants' use of physical aggression and sexual coercion. Reports of partner withdrawal and partner controlling behaviors were associated with participants' sexual coercion only. Significant moderating effects of gender emerged. As expected, partner demands, controlling behaviors, and psychological abuse were associated with physical aggression and sexual coercion in men, but not women. Partner withdrawal was associated with sexual coercion in both women and men. We conclude that gender-sensitive approaches are necessary to understand and prevent verbal conflict patterns associated with physical aggression and sexual coercion in intimate relationships.     

Le faux problème de l'indéfinition de la religion: les origines du ‘problème’ et ses enjeux actuels

When one refuses to participate in shallow debates on the definition of religion, which define in general tactics of declassing the beliefs of others or of under-classing our own beliefs, one recognizes that beyond the emerging patchworked spiritual diversification which emerges in today's advanced industrial societies there is a unified religious dogma. The idea that spirituality will be contradictory to religion does not constitute a pertinent concrete distinction, but occupies a place in this new religious dogma that presents itself as spiritual.     

Drinking Motives,Alcohol Use,and Sexual Attraction in Youth

Sexual minority youth were found to be more likely to drink alcohol during weekdays compared to heterosexual youth. Drinking during weekdays was associated with consuming alcohol as a coping strategy. Sexual minority youth also more frequently consumed alcohol to eliminate personal worries (coping) and to not be excluded by their peers (conformity). Sexual orientation–related alcohol problems should be addressed at an early stage. Such efforts are likely to be effective if insecurities and stress related to sexual orientation are addressed as well.