Identifying radon-prone building typologies by marginal modelling

Radon is a naturally occurring decay product of uranium known to be the main contributor to natural background radiation exposure. It has been established that the health risk related to radon exposure is lung cancer. In fact, radon is considered to be a major leading cause of lung cancer, second only to smoking. In this paper, we identified building typologies that affect the probability of detecting indoor radon concentration above reference values, using the data collected within two monitoring campaigns recently conducted in Northern Italy. This information is fundamental both in prevention, i.e. when the construction of a new building is planned and in mitigation, i.e. when a high concentration detected inside buildings has to be reduced. A spatial regression approach for binary data was adopted for this goal where some relevant covariates on the soil were retrieved by linking external spatial databases.     

Bayesian quantile regression for single-index models

Using an asymmetric Laplace distribution, which provides a mechanism for Bayesian inference of quantile regression models, we develop a fully Bayesian approach to fitting single-index models in conditional quantile regression. In this work, we use a Gaussian process prior for the unknown nonparametric link function and a Laplace distribution on the index vector, with the latter motivated by the recent popularity of the Bayesian lasso idea. We design a Markov chain Monte Carlo algorithm for posterior inference. Careful consideration of the singularity of the kernel matrix, and tractability of some of the full conditional distributions leads to a partially collapsed approach where the nonparametric link function is integrated out in some of the sampling steps. Our simulations demonstrate the superior performance of the Bayesian method versus the frequentist approach. The method is further illustrated by an application to the hurricane data.     

Understanding increments in model performance metrics

The area under the receiver operating characteristic curve (AUC) is the most commonly reported measure of discrimination for prediction models with binary outcomes. However, recently it has been criticized for its inability to increase when important risk factors are added to a baseline model with good discrimination. This has led to the claim that the reliance on the AUC as a measure of discrimination may miss important improvements in clinical performance of risk prediction rules derived from a baseline model. In this paper we investigate this claim by relating the AUC to measures of clinical performance based on sensitivity and specificity under the assumption of multivariate normality. The behavior of the AUC is contrasted with that of discrimination slope. We show that unless rules with very good specificity are desired, the change in the AUC does an adequate job as a predictor of the change in measures of clinical performance. However, stronger or more numerous predictors are needed to achieve the same increment in the AUC for baseline models with good versus poor discrimination. When excellent specificity is desired, our results suggest that the discrimination slope might be a better measure of model improvement than AUC. The theoretical results are illustrated using a Framingham Heart Study example of a model for predicting the 10-year incidence of atrial fibrillation.     

On optimising the estimation of high quantiles of a probability distribution

One of the major aims of one-dimensional extreme-value theory is to estimate quantiles outside the sample or at the boundary of the sample. The underlying idea of any method to do this is to estimate a quantile well inside the sample but near the boundary and then to shift it somehow to the right place. The choice of this “anchor quantile” plays a major role in the accuracy of the method. We present a bootstrap method to achieve the optimal choice of sample fraction in the estimation of either high quantile or endpoint estimation which extends earlier results by Hall and Weissman (1997) in the case of high quantile estimation. We give detailed results for the estimators used by Dekkers et al. (1989). An alternative way of attacking problems like this one is given in a paper by Drees and Kaufmann (1998).     

Optimal designs for exponential regression

This paper is concerned with the optimal design problem for the particular case of non-linear parametrisation:the parameters to be estimated are included in exponents.Some properties of locally optimal designs as functions of estimated parameters are investigated and a table of such designs in given.We consider also designs to be optimal in the sense of minimax approach.     

Exact distribution of the MLEs of the parameters and of the quantiles of two-parameter exponential distribution under hybrid censoring

Epstein [Truncated life tests in the exponential case, Ann. Math. Statist. 25 (1954), pp. 555–564] introduced a hybrid censoring scheme (called Type-I hybrid censoring) and Chen and Bhattacharyya [Exact confidence bounds for an exponential parameter under hybrid censoring, Comm. Statist. Theory Methods 17 (1988), pp. 1857–1870] derived the exact distribution of the maximum-likelihood estimator (MLE) of the mean of a scaled exponential distribution based on a Type-I hybrid censored sample. Childs et al. [Exact likelihood inference based on Type-I and Type-II hybrid censored samples from the exponential distribution, Ann. Inst. Statist. Math. 55 (2003), pp. 319–330] provided an alternate simpler expression for this distribution, and also developed analogous results for another hybrid censoring scheme (called Type-II hybrid censoring). The purpose of this paper is to derive the exact bivariate distribution of the MLE of the parameter vector of a two-parameter exponential model based on hybrid censored samples. The marginal distributions are derived and exact confidence bounds for the parameters are obtained. The results are also used to derive the exact distribution of the MLE of the pth quantile, as well as the corresponding confidence bounds. These exact confidence intervals are then compared with parametric bootstrap confidence intervals in terms of coverage probabilities. Finally, we present some numerical examples to illustrate the methods of inference developed here.     

On the construction of optimal experimental designs: a penalty approach

Tn optimal experimental design theory there are well-known situations, in which additional constraints are implied to the design set. These constraints destroy in general the simplex structure of the set of feasible points of the design set. Thus the available iteration procedures for the unrestricted case are no longer applicable.

In this paper a penalty approach is suggested which transforms the restricted problem to the unrestricted case and allows the application of well-known algorithms such as the Fedorov-Wynn-type or the projected gradient procedure.