Impulse Control Disorder Behaviors Associated with Pramipexole Used to Treat Fibromyalgia

Objective: Compulsivity has been associated with use of dopamine agonists used to treat Parkinson’s disease (PD). Increasing use of these agents to treat fibromyalgia (FM) raises concern for this unexpected toxicity in a new group of patients. This is the first report of compulsive gambling and shopping among patients taking dopamine agonists for treatment of FM. Design: A retrospective chart review of all patients in a large, active FM research practice was used to identify compulsivity associated with dopamine agonists and describe its remission following dug withdrawal. Results: Of 3006 patients with FM treated between 2002 and 2006, 1356 had taken ≥1 dose of a dopamine agonist ( >95% pramipexole). Twenty-one (3 male, 18 female) were identified with compulsive gambling (33%), shopping (40%) or both (27%) after taking a 4.5 mg mean dose of pramipexole at bedtime for 14.4 ± 14.9 months. Compulsivity resolved in 3–10 days for 19 of 21 patients and by 3 months for all following a monitored, compulsory tapered discontinuation over 7 days. Conclusions: While biologic aspects of PD and FM differ considerably, compulsive gambling and shopping have become important, yet unexpected concerns related to use of dopamine agonists for patients with FM and their treating clinicians.     

How Mood and Task Complexity Affect Children's Recognition of Others' Emotions

Previous studies examined how mood affects children's accuracy in matching emotional expressions and labels (label‐based tasks). This study was the first to assess how induced mood (positive, neutral, or negative) influenced five‐ to eight‐year‐olds' accuracy and reaction time using both context‐based tasks, which required inferring a character's emotion from a vignette, and label‐based tasks. Both tasks required choosing one of four facial expressions to respond. Children responded more accurately to label‐based questions relative to context‐based questions at the age of five to seven, but showed no differences at the age of eight, and when the emotional expression being identified was happiness, sadness, or surprise, but not disgust. For the context‐based questions, children were more accurate at inferring sad and disgusted emotions compared with happy and surprised emotions. Induced positive mood facilitated five‐year‐olds' processing (decreased reaction time) in both tasks compared with induced negative and neutral moods. Results demonstrate how task type and children's mood influence children's emotion processing at different ages.     

‘I shouldn’t be living there because I am a sponger’: negotiating everyday geographies by people with learning disabilities

Learning disability policy has for some time been framed by the goal of inclusion which purports to enable people with learning disabilities to lead a ‘life like any other’ person. This article examines the extent to which this is the case in England, by tracing the lived experiences of people with learning disabilities within their communities. The article draws on two interlinked qualitative studies involving interviews that examined their local place-based experiences of inclusion and exclusion. The findings reveal ‘moments of inclusion’ and opportunities for social encounter from peer support, but these were situated amidst wider experiences of exclusion and harassment.     

Confidence intervals for treatment effect from restricted maximum likelihood

An explicit form of confidence intervals for the treatment effect in random effects meta-analysis model obtained from Harville–Jeske–Kenward–Roger approach is given. These restricted likelihood based intervals are compared to alternative procedures commonly used in collaborative studies when the number of participants is small and study-specific variances are heterogeneous. Monte Carlo simulation experiments show that the former intervals have quite conservative coverage probabilities and favor the latter intervals.     

Economics,psychotherapy and politics

The paper explores the application of ideas derived from psychotherapy to questions of economic and social policy. It is argued that disputes concerning human nature underlie many debates on economic theory. Class is reviewed from internal and emotional perspectives. Psychological obstacles to the achievement of economic inequality are explored and ways of overcoming them critically discussed. Particular attention is paid to the operation of economic sadism in the behaviour of individuals and societies. A range of possible gender differences in relation to money is reviewed. Inherited wealth is explored from the perspective of ‘therapy thinking’. The paper proposes that we reconsider what is deemed to be realistic and what is deemed to be (hopelessly) idealistic in thinking about economics. The paper concludes by proposing a deeper discussion of the problematic of sacrifice in connection with sustainable economics.     

马克思1842年的“国家”基础

作为黑格尔左派的青年马克思基本按照黑格尔的方式思考国家的本质、集体精神以及实证法等问题。尽管马克思很快与青年黑格尔派决裂并最终转向唯物主义的历史理论,但是其成熟的历史理论中仍然保留着黑格尔思考国家本质时采用的思想进路。     

An F Approximation to the Distribution of a Linear Combination of Chi-squared Variables.

A three-parameter F approximation to the distribution of a positive linear combination of central chi-squared variables is described. It is about as easy to implement as the Satterthwaite-Welsh and Hall-Buckley-Eagleson approximations. Some reassuring properties of the F approximation are derived, and numerical results are presented. The numerical results indicate that the new approximation is superior to the Satterthwaite approximation and, for some purposes, better than the Hall-Buckley-Eagleson approximation. It is not quite as good as the Gamma-Weibull approximation due to Solomon and Stephens, but is easier to implement because iterative methods are not required.     

Into the divide: community identities and the visualisation of place

This article discusses the experience of place in a profoundly divided urban area of Sheffield. At a time when the gap between affluence and poverty has reached its widest point since the 1960s, this article explores the relationship between individuals and their sense of place and of the trenchant divisions separating communities. The study employs various methods but centres upon the use of hand-drawn maps; creating a dialogue between the interviewers and a number of local residents. These maps and the accompanying commentaries demonstrate the diverse individual sense of a particular place and a dialectical sense of space. The resulting picture is one of both the persistence of historical divisions, suggesting regulation and control through planning and policing, but also of complex entanglements of social identities, habitus and place which defy easy categorisation.     

Through Civil War, Food Crisis and Drought: Trends in Fertility and Nuptiality in Post-Soviet Tajikistan

This article has two objectives. First, it aims to complement and extend existing research on post-socialist demographic change, which has thus far tended to focus on Central and Eastern Europe. It does this by describing the nature of post-Soviet trends in nuptiality and fertility in Tajikistan, the republic with the highest rate of population growth during the Soviet period. It finds evidence for a decrease in period fertility after independence: initially, through a decline at higher orders; then, through a significant decrease in the rate of first births, associated with a dramatic decrease in the rate of first union formation since the mid-1990s. Second, it aims to contribute to the demography of conflict and of food crisis. Most clearly, it finds strong evidence for a decrease in nuptiality and fertility associated with the 1995 food crisis.