Complete diallel crosses plans through balanced incomplete block designs

The present investigation involves the methods of construction of complete diallel cross plans using balanced incomplete block (BIB) designs. Furthermore, the analysis of complete diallel crosses plans are carried out to estimate the general combining ability of the ith line (i=1, r 2, r …, r v) where the intra- block analysis of the adjusted sum of squares for GCA and the unadjusted block sum of squares are also obtained, thereafter the relationship between the estimates of BIB design and the estimates of the GCA effect of CDC plan has been established. Moreover, it has also been shown that the complete diallel crosses design obtained through two BIB designs satisfying v1=b1= 4 5 1+3=v2=b2, r r1=2 5 1+1=r2=k1=k2 and 5 1= 5 2 are universally optimum. These results are further supported by a suitable example of each. However, the need of this study is to show that the analysis of the CDC plan is reducible to the analysis of generating the BIB design.     

Sequential-type nonparametric test using Mann-Whitney statistics

The paper provides a nonparametric test for the identity of two continuous univariate distribution functions when observations are drawn in pairs from the populations, by adopting a sampling scheme which, using Mann-Whitney scores, generalizes the existing inverse binomial sampling technique. Some exact performance characteristics of the proposed test are formulated and compared numerically with existing competitors of the proposed test. The applicability of the proposed test is illustrated using real-life data.     

Incremental Validity of Stressful Life Experiences in Predicting Psychiatric Comorbidity Among Women in Substance Abuse Treatment

ABSTRACT

The dynamic contribution of stressful life experiences in predicting psychiatric comorbidity continues to challenge clinical practice and research. This study tested incremental validity of stressful life experiences related to psychiatric comorbidity among 128 young women in a Midwestern substance abuse treatment facility. Respondents reported low income, homelessness, and health and mental health issues. Using the Addiction Severity Index (ASI), Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, Text Revision, and Stressful Life Experience (SLE) Screen as correlates, hierarchical linear regression demonstrated support for incremental validity of SLE uniquely accounting for 6.5% of variance in ASI psychiatric scores. Findings support future use of SLE in clinical settings for assessment and intervention purposes.     

A RANDOMIZED LONGITUDINAL PLAY-THE-WINNER DESIGN FOR REPEATED BINARY DATA

In some clinical trials with two treatment arms, the patients enter the study at different times and are then allocated to one of two treatment groups. It is important for ethical reasons that there is greater probability of allocating a patient to the group that has displayed more favourable responses up to the patient's entry time. There are many adaptive designs in the literature to meet this ethical constraint, but most have a single binary response. Often the binary response is longitudinal in nature, being observed repeatedly over different monitoring times. This paper develops a randomized longitudinal play‐the‐winner design for such binary responses which meets the ethical constraint. Some performance characteristics of this design have been studied. It has been implemented in a trial of pulsed electro‐magnetic field therapy with rheumatoid arthritis patients.     

Controlling Type-I Error Rate in Monitoring Structural Changes Using Partially Sequential Procedures

In the present article, we develop some asymptotically power on partially sequential nonparametric tests for monitoring structural changes. Our test procedures are based on Wilcoxon score. We use the idea of curved stopping boundaries. We derive some exact results and perform simulation studies to provide various properties of the tests. We see that one of the proposed procedures significantly controls the Type I error rate. This procedure may be very effective for fluctuation monitoring. We illustrate the procedures by using real life data from the stock market.     

A response-adaptive design in crossover trial

In the present work, whenever the response variables are binary, we frame an adaptive allocation rule for a two-treatment two-period crossover design in the presence of possible carry-over effects. The proposed rule is a combination of the play-the-winner and randomized play-the-winner rules. We study various properties of the proposed rule through asymptotics and simulations. Some related inferential problems are also considered. The proposed procedure is compared with some possible competitor.     

Time series analysis of categorical data using auto-odds ratio function

In this paper, we consider the auto-odds ratio function (AORF) as a measure of serial association for a stationary time series process of categorical data at two different time points. Numerical measures such as the autocorrelation function (ACF) have no meaningful interpretation, unless the time series data are numerical. Instead, we use the AORF as a measure of association to study the serial dependency of the categorical time series for both ordinal and nominal categories. Biswas and Song [Discrete-valued ARMA processes. Stat Probab Lett. 2009;79(17):1884–1889] provided some results on this measure for Pegram's operator-based AR(1) process with binary responses. Here, we extend this measure to more general set-ups, i.e. for AR(p) and MA(q) processes and for a general number of categories. We discuss how this method can effectively be used in parameter estimation and model selection. Following Weiß [Empirical measures of signed serial dependence in categorical time series. J Stat Comput Simul. 2011;81(4):411–429], we derive the large sample distribution of the estimator of the AORF under independent and identically distributed (iid) set-up. Some simulation results and two categorical data examples (one is ordinal and other nominal) are presented to illustrate the proposed method.     

Nonparametric estimation of 100(1 − p)% expected shortfall: p → 0 as sample size is increased

Expected shortfall (ES) is a well-known measure of extreme loss associated with a risky asset or portfolio. For any 0 < p < 1, the 100(1 ? p) percent ES is defined as the mean of the conditional loss distribution, given the event that the loss exceeds (1 ? p)th quantile of the marginal loss distribution. Estimation of ES based on asset return data is an important problem in finance. Several nonparametric estimators of the expected shortfall are available in the literature. Using Monte Carlo simulations, we compare the accuracy of these estimators under the condition that p → 0 as n → ∞ for several asset return time series models, where n is the sample size. Not much seems to be known regarding the properties of the ES estimators under this condition. For p close to zero, the ES measures an extreme loss in the right tail of the loss distribution of the asset or portfolio. Our simulations and real-data analysis provide insight into the effect of varying p with n on the performance of nonparametric ES estimators.     

A note on the generalization of William Brass’s model

Demography - The purpose of the present communication is to generalize a model of Brass’s (1958), relating to the probability distribution of births to mothers with completed fertility. A...