Diagnostic significance of free salivary testosterone measurement using a direct luminescence immunoassay in healthy men and in patients with disorders of androgenic status

The accurate measurement of testosterone remains a challenge. The determination of the blood testosterone concentrations in serum by conventional immunoassays is inaccurate in men and even more so in females and children. A new luminescence enzyme immunoassay (LIA) has been developed and validated. The high analytical (8.7 pmol/L) and functional (17.3 pmol/L) sensitivity allows the quantification of the very low concentration in saliva, as well as in serum, after 1/40 dilution. This study measured salivary testosterone levels and compared the results with the free levels calculated from total testosterone and sex hormone-binding globulin in eugonadal and hypogonadal men. Salivary testosterone concentrations in healthy men in morning hours were 369 pmol/L (mean), range 263–544 pmol/L, which was statistically significantly higher than that in men with androgen deficiency, 215 pmol/L (mean), range 51–249 pmol/L.

Repetitive determination of free testosterone concentrations in saliva (once a week for 5 weeks) showed high stability of results over time, with coefficient of variation 9% (range 5–23%).

In this study we showed that free salivary testosterone levels in morning samples correlated well with calculated free testosterone in blood, both in healthy men (R = 0.754, P = 0.001), and in patients with androgen deficiency (R = 0.889, P = 0.0001), though in cases with very low testosterone, salivary concentrations were systematically higher than calculated free testosterone levels in blood.     

The bidirectional relationship between gambling and addictive substances

This study aims to analyse the co-occurrence of gambling activity and the consumption of addictive substances, such as tobacco, alcohol and drugs. By using a sample of 709 gamblers in Sardinia (Italy), a multivariate probit approach is proposed since it allows simultaneous study of the extent of correlation between the consumption of different substances.

Our findings document that, on the one hand, betting more money leads to an increase in the propensity to consume tobacco in the middle of the game, and, on the other hand, the simultaneous co-occurrence of smoking, alcohol and drugs drives up the probability of getting more involved in gambling activity. Knowing the positive reinforcing effects of addictive substances is the first step towards implementing the most effective prevention and treatment modalities for problem/pathological gamblers.     

A prevalence study of children with imprisoned fathers: annual and lifetime estimates

In Australia, data are not routinely collected on the parental status of prisoners, so there are no official nationwide figures and few State‐based figures. The current study uses data collected in Queensland over a six‐month period to estimate how many Queensland children, in one year and in their entire childhood, experience paternal imprisonment. Additional data were collected relating to the provision of care for the child prior to, and during, their father's imprisonment. Participants were 303 imprisoned fathers (51 per cent of Aboriginal and/or Torres Strait Islander origin) who reported a total of 753 children. Using these data and population statistics, it was estimated that 0.8 per cent of children in Queensland experienced paternal imprisonment in one year while approximately four per cent experience paternal imprisonment in their lifetime. Indigenous children were nine times more likely to experience paternal imprisonment in one year and four times more likely to experience paternal imprisonment in their lifetime compared to non‐Indigenous children. Approximately half of the children (48 per cent) lived with their father prior to his imprisonment. Results are discussed in relation to whether children were living with their father as well as the possibility of pre‐existing risks in children's lives that may subsequently interact with their father's imprisonment.     

Impact of Geriatric Assessment and Self-Management Support on Community-Dwelling Older Adults with Chronic Illnesses

Purpose: The purpose of this study was to assess the effectiveness of interdisciplinary geriatric home-based assessment and self-management support services to community-dwelling older adults. Design: A quasi-experimental, pre-post test design tested two types of service delivery models. The first protocol included geriatric assessment services, with a brief self-management care plan intervention. The second protocol added a telephone support intervention. Results: All participants showed significant progress in improved self–efficacy, self-rated health, functional status and physical mobility (specifically lower extremity muscle strength), mental health (specifically reduced depression) and in reduced fall hazards in their physical home environment. The telephone support intervention protocol did not provide additional value to the first protocol. Implications: This study demonstrates the value of non-medical intervention strategies for community dwelling older adults with chronic illnesses.     

Diverse Effects of Women’s Employment on Fertility: Insights From Italy and Poland

In this paper, we look into how country-specific factors shape the interrelationship between childbearing and women’s labor supply. To this end, we compare Italy and Poland, two low-fertility countries where the country-specific obstacles to work and family reconciliation are similarly strong but which differ in the history of women’s labor supply and the extent to which couples’ material aspirations are satisfied by men’s earnings. Our findings show that women’s employment clearly conflicts with childbearing in Italy, while in Poland women tend to combine the two activities, despite the similar difficulties they face. These results challenged the standard microeconomic explanations and point to the importance of other country-specific factors, apart from conditions for work and family reconciliation, in shaping women’s employment and fertility decisions, such as economic incentives or culturally rooted behavioral patterns. Overall, our study provides thus foundations for explaining the variation in the relationship between women’s employment and fertility in an enlarged Europe.     

Daily Spillover of Low‐Income Mothers' Perceived Workload to Mood and Mother–Child Interactions

This study investigated associations of low‐income working mothers' daily perceived workload and their reports of their own mood and their interactions with their young children. Sixty‐one mothers were asked to report on their workload, mood, and interactions with their preschool‐age children every day for 2 weeks (N = 520 work days). Low‐income mothers reported significant day‐to‐day variability in workload. The results revealed a curvilinear pattern of negative work‐to‐family spillover: Both lower‐than‐average and higher‐than‐average workload days were associated with increased negative and tired mood, decreased positive mood, and increased harsh mother–child interactions. Although both younger and older mothers experienced a curvilinear pattern of spillover to daily mood, younger mothers in the period of emerging adulthood also experienced spillover to mother–child interactions, perhaps because they are still learning how to balance work and family demands. Both high and low workload are salient stressors in the daily lives of low‐wage working mothers.     

Adolescent Loneliness and Health in Early Adulthood

The health consequence of loneliness in the early life course is an understudied topic in the sociological literature. Using data from Waves 1–3 of the National Longitudinal Study of Adolescent Health, we examine pre‐disease pathways in the relationship between adolescent loneliness and early adult health. Our results indicate that loneliness during adolescence is associated with diagnosed depression, poorer adult self‐rated health, and metabolic risk factors related to cardiovascular disease. High depressive symptoms and parent support are important pathways through which the health consequences of loneliness are exacerbated or offset. There is also evidence that lonely youth remain at higher risk for experiencing adult depression and poor self‐rated health even in the presence of equivalent levels of parental support relative to non‐lonely adolescents. Furthermore, lonely adolescent females are more vulnerable to reporting poor adult self‐rated health and being overweight or obese in adulthood. In sum, our study demonstrates the importance of adolescent loneliness for elevating the risk of poor health outcomes in adulthood.     

A longitudinal examination of risk and protective factors associated with drug use and unsafe sex among young African American females

This study prospectively examined associations among multiple theoretically informed risk (e.g., depression, sexual sensation seeking, and risky peers norms) and protective factors (e.g., social support, STI knowledge, and refusal to have sex self efficacy) on unsafe sex among 715 African American adolescent females aged 15–21 who participated in an STI/HIV prevention intervention. Generalized estimating equation models were used to assess associations between baseline characteristics and sexual risk over a 12-month follow-up period. Overall risk in this population was high: at baseline, nearly a third of women reported sex under the influence of alcohol or substances; ≥ 2 partners for vaginal sex, and casual sex partners in the 60 days prior to baseline, and nearly 75% of those reporting vaginal sex used condoms inconsistently. In multivariable analysis, when risk and protective factors were simultaneously considered, higher levels of sexual sensation seeking were associated with having multiple sex partners and inconsistent condom use. Greater perception of risky peer norms was associated with a higher risk of having sex under the influence of alcohol or drugs. In addition, higher sex refusal self-efficacy was protective against having multiple; casual; and concurrent sex partners. Incorporating these salient factors into prevention programs may be critical to the development of targeted interventions for this population.