Comparison of the EU T25 Single Point Estimate Method with Benchmark Dose Response Modeling for Estimating Potency of Carcinogens

The T25 single-point estimate method of evaluating the carcinogenic potency of a chemical, which is currently used by the European Union (EU) and is denoted the EU approach, is based on the selection of a single dose in a chronic bioassay with an incidence rate that is significantly higher than the background rate. The T25 is determined from that single point by a linear extrapolation or interpolation to the chronic dose (in mg/kg/day), at which a 25% increase in the incidence of the specified tumor type is expected, corrected for the background rate. Another method used to obtain a carcinogenic potency value based on a 25% increase in incidence above the background rate is the estimation of a T25 derived from a benchmark dose (BMD) response model fit to the chronic bioassay data for the specified tumor type. A comparison was made between these two methods using 276 chronic bioassays conducted by the National Toxicology Program. In each of the 2-year bioassays, a tumor type was selected based on statistical and biological significance, and both EU T25 and BMD T25 estimates were determined for that end point. In addition, simulations were done using underlying cumulative probability distributions to examine the effect of dose spacing, the number of animals per dose group, the possibility of a dose threshold, and variation in the background incidence rates on the EU T25 and BMD estimates. The simulations showed that in the majority of cases the EU T25 method underestimated the true T25 dose and overestimated the carcinogenic potency. The BMD estimate is generally less biased and has less variation about the true T25 value than the EU estimate.     

Identifying social innovations in European local rural development initiatives

Social innovation is attracting increasing attention in research and policy, heightened by continuing austerity across Europe. Therefore, this paper examines earlier research into community-led local development (CLLD) initiatives in rural areas of Europe to develop our understanding of the meaning and scope of rural social innovation. We draw on a Schumpeterian view where innovations emerge from new combinations of resources that bring about positive changes and create value in society. A Schumpeterian social innovation framework is derived as the basis for re-analysing data from previous evaluations of LEADER policy in five different national contexts. This elicits a clearer understanding of social innovation in a rural development context, identifying different processes and outcomes that create social value. As the CLLD agenda and the demand for innovation in Europe gather pace, our aspirations are to inform future research and other initiatives on how to integrate social innovation into the design and evaluation of new rural development policies and programmes.     

Environmental determinism as Orientalism: The geo-political ecology of crisis in the Middle East

From ‘Resource Curse’ to ‘Climate Conflict’, more and more analyses of the current crisis in the Middle East start their reasoning from geo-physical or natural conditions as determinants of social life. Paradoxically, despite its resource riches giving rise to conflict, the region's ecology is portrayed as fragile, alien and hostile. This imperial oriental imagination, assumes that a scarce nature is mismanaged by societies and states overall incapable of negotiating modernity. This precarious, crisis driven environment is now pushed to the edge by the effects of climate change with looming desertification and weather extremes and a scramble for shrinking oil reserves threatening to make the region all but inhabitable. This article suggests that this environmental oriental determinism in Middle East can be overcome by entering political ecology into the register of historical sociological analysis. Re-socialising and historicising nature-society relations avoids reifying the Cartesian nature/society divide, offering historical sociology a better toolkit to navigate the current crisis. Vice-versa, it argues that political ecology can benefit from recognising the role of geopolitical relations in the social reproduction nature.     

Concurrent reductions in psychotropic medication,assault, and physical restraint in two residential treatment programs for youth

Over the past decade, the level of clinical needs of youth in residential treatment has increased significantly. Youth in out-of-home settings typically experience higher levels of psychotropic medication use than their peers living at home, even when controlling for the severity of clinical issues. The purpose of the current study was to examine the effects of an approach to clinically reassess psychotropic medication utilization for youth residing in residential treatment settings while also observing the impact on the youth's need for physical containment. Medication changes were based on a data-informed process, using input from a multi-disciplinary treatment team. Data for 531 youth who were consecutively admitted to one of two non-affiliated intensive residential treatment programs, one in the Midwest and one in New England, was analyzed. Over half of these youth (n = 292, 55%) had their medications reduced during their stay and only 14% (n = 76) were prescribed more medication at discharge than they had been taking at admission. The remainder either saw no change during their stay (n = 104, 20%) or were never on medication at any time (n = 59, 11%). From admission to discharge there was a 62% decrease in the number of assaultive incidents as well as a 72% decrease in the use of physical restraints. These results support the view that residential treatment can provide a treatment milieu that allows for thoughtful reassessment of the clinical basis for behavioral disorders in children that can achieve the dual goals of medication reduction and behavioral stabilization.     

Comparing Observed and Unobserved Components of Childhood: Evidence From Finnish Register Data on Midlife Mortality From Siblings and Their Parents

In this study, we argue that the long arm of childhood that determines adult mortality should be thought of as comprising an observed part and its unobserved counterpart, reflecting the observed socioeconomic position of individuals and their parents and unobserved factors shared within a family. Our estimates of the observed and unobserved parts of the long arm of childhood are based on family-level variance in a survival analytic regression model, using siblings nested within families as the units of analysis. The study uses a sample of Finnish siblings born between 1936 and 1950 obtained from Finnish census data. Individuals are followed from ages 35 to 72. To explain familial influence on mortality, we use demographic background factors, the socioeconomic position of the parents, and the individuals’ own socioeconomic position at age 35 as predictors of all-cause and cause-specific mortality. The observed part—demographic and socioeconomic factors, including region; number of siblings; native language; parents’ education and occupation; and individuals’ income, occupation, tenancy status, and education—accounts for between 10 % and 25 % of the total familial influence on mortality. The larger part of the influence of the family on mortality is not explained by observed individual and parental socioeconomic position or demographic background and thus remains an unobserved component of the arm of childhood. This component highlights the need to investigate the influence of childhood circumstances on adult mortality in a comprehensive framework, including demographic, social, behavioral, and genetic information from the family of origin.     

Musculoskeletal problems in bricklayers as a function of length of employment: The role of secondary selection by low-back pain

Abstract

Low-back problems that are caused by heavy physical work should increase with the length of employment. In a cross-sectional study 195 bricklayers were interviewed and subjected to a medical examination concerned with complaints and functional impairments of the musculoskeletal systems of different body regions (neck/shoulder, arms/hands, back, hip/legs/feet). Summary variables for complaints and impairments indicated an increase with increasing age. Contrary to expectation, in pairs of bricklayers of the same age, but different length of employment, a general decline of complaints and impairments with longer employment was observed. This finding suggested a healthy worker effect. In a follow-up the turnover rate among 190 of the 195 bricklayers of the original study was determined. Bricklayers who had quit the job had a higher incidence of low-back troubles before leaving than bricklayers who had stayed in the job; the relation between turnover and low-back problems was limited to bricklayers older than about 40 years.     

Parental Socioeconomic Background and Child Behaviour

Although childhood obesity has long been in focus, little is known about the sensitivity of behavioural choices to measure parental resource constraints. The aim of this study is to examine the heterogeneous effects of children’s (or their parents’) choices of lifestyle subject to information and resource constraints, respectively. We address this issue using a unique longitudinal data set of almost 1,500 schoolchildren attending state schools between 2008 and 2010 in the Danish Municipality of Aalborg. One empirical strategy is to control for a rich set of child and parental characteristics; another is to use child fixed effect to control for fixed unobserved child characteristics. By including the interaction between child behaviour and parental socioeconomic background, a more complete but more complex picture arises. Our findings challenge the predominant assumption that behaviour and weight is a choice made by children, or their parents.     

Analysis of short-term systematic measurement error variance for the difference of paired data without repetition of measurement

The variance of short-term systematic measurement errors for the difference of paired data is estimated. The difference of paired data is determined by subtracting the measurement results of two methods, which measure the same item only once without measurement repetition. The unbiased estimators for short-term systematic measurement error variances based on the one-way random effects model are not fit for practical purpose because they can be negative. The estimators, which are derived for balanced data as well as for unbalanced data, are always positive but biased. The basis of these positive estimators is the one-way random effects model. The biases, variances, and the mean squared errors of the positive estimators are derived as well as their estimators. The positive estimators are fit for practical purpose.     

从心理学走向形而上学——詹姆斯“意识流”学说及其哲学意蕴

詹姆斯的意识流学说使他的心理学具有一种独特的原创性.其中特别值得关注的是他关于心理学的直接描述法和意识现象连续性特征的强调.但意识流学说尚未克服传统二元论的痕迹,这导致了詹姆斯后来向经验主义的转变.意识流学说直接影响了詹姆斯对经验主义的阐述,同时意识流学说中的二元论色彩,也在后来的经验学说那里留下了印记,使詹姆斯的彻底经验主义最终没能真正摆脱基础主义的覆辙.