A comparison of classification models to identify the Fragile X Syndrome

The main models of machine learning are briefly reviewed and considered for building a classifier to identify the Fragile X Syndrome (FXS). We have analyzed 172 patients potentially affected by FXS in Andalusia (Spain) and, by means of a DNA test, each member of the data set is known to belong to one of two classes: affected, not affected. The whole predictor set, formed by 40 variables, and a reduced set with only nine predictors significantly associated with the response are considered. Four alternative base classification models have been investigated: logistic regression, classification trees, multilayer perceptron and support vector machines. For both predictor sets, the best accuracy, considering both the mean and the standard deviation of the test error rate, is achieved by the support vector machines, confirming the increasing importance of this learning algorithm. Three ensemble methods - bagging, random forests and boosting - were also considered, amongst which the bagged versions of support vector machines stand out, especially when they are constructed with the reduced set of predictor variables. The analysis of the sensitivity, the specificity and the area under the ROC curve agrees with the main conclusions extracted from the accuracy results. All of these models can be fitted by free R programs.     

`Sex-Equal' Stable Matchings

The paper defines a measure on the set of stable matchings in the marriage problem. This measure is based on the minimization of the envy difference between the sets of men and women, while preserving stability and selects stable matchings with the least conflict of interest between both groups of agents. The solution concept proposed is called Sex-equal Matching (SEM) and the paper also provides an algorithm to compute the set of SEM.     

Social mobility and demand for redistribution in Europe: a comparative analysis

The literature on preferences for redistribution has paid little attention to the effect of social mobility on the demand for redistribution and no systematic test of the hypotheses connecting social mobility and preferences for redistribution has yet been done to date. We use the diagonal reference model to estimate the effect of origin and destination classes on preferences for redistribution in a large sample of European countries using data from the European Social Survey. Our findings are consistent with the logic of acculturation in the sense that newcomers tend to adapt their views to those of the destination class at early stages and that upward and downward mobility do not have distinctive effects on the formation of political preferences. However, even though social origins seem to have a limited impact on preferences for redistribution, the evidence does not support the hypothesis that mobile and non‐mobile individuals are alike. We also find that the effect of social origin on preferences varies largely across countries. The empirical evidence leads to the conclusion that the effect of social origin on preferences for redistribution increases in contexts of strong familism.     

Physical activity is inversely related to drug consumption in elderly patients with cardiovascular events

Elderly patients with cardiovascular events are characterized by high drug consumptions. Whether high drug consumptions are related to physical activity is not known. In order to examine whether physical activity is related to drug consumption in the elderly, patients older than 65 years (n?=?250) with a recent cardiovascular event were studied. Physical activity was analyzed according to the Physical Activity Scale for the Elderly (PASE) score and related to drug consumption. PASE score was 72.4?±?45.0 and drug consumption was 8.3?±?2.2. Elderly patients with greater comorbidity took more drugs (8.7?±?2.1) and are less active (PASE?=?64.4?±?50.6) than patients with Cumulative Illness Rating Scale severity score higher than 1.8 than those with a score lower than 1.8 (76.3?±?41.4, p?<?0.05, and 8.0?±?2.0, p?=?0.006, respectively). Multivariate analysis correlation confirmed that PASE score is negatively associated with drug consumption (β?=??0.149, p?=?0.031), independently of several variables including comorbidity. Thus, physical activity is inversely related to drug consumption in elderly patients with cardiovascular events. This inverse relationship may be attributable to the high degree of comorbidity observed in elderly patients in whom poor level of physical activity and high drug consumption are predominant.     

Assessing the pattern of covariance matrices via an augmentation multiple testing procedure

This paper extends the scedasticity comparison among several groups of observations, usually complying with the homoscedastic and the heteroscedastic cases, in order to deal with data sets laying in an intermediate situation. As is well known, homoscedasticity corresponds to equality in orientation, shape and size of the group scatters. Here our attention is focused on two weaker requirements: scatters with the same orientation, but with different shape and size, or scatters with the same shape and size but different orientation. We introduce a multiple testing procedure that takes into account each of the above conditions. This approach discloses a richer information on the data underlying structure than the classical method only based on homo/heteroscedasticity. At the same time, it allows a more parsimonious parametrization, whenever the patterned model is appropriate to describe the real data. The new inferential methodology is then applied to some well-known data sets, chosen in the multivariate literature, to show the real gain in using this more informative approach. Finally, a wide simulation study illustrates and compares the performance of the proposal using data sets with gradual departure from homoscedasticity.     

Regulation and the future of work: The employment relationship as an innovation facilitator

Digital transformation and the reorganization of the firm have given rise to new forms of work that diverge significantly from the standard employment relationship. Advocates of digital disruption suggest that the existing legal framework cannot accommodate “innovative” working templates and business models. This article, however, argues that labour regulation can continue to facilitate innovation, presenting the employment relationship as a flexible instrument, and standard forms of employment as the means of achieving efficiencies and cost advantages. First, they allow for the full exercise of managerial prerogative and attendant internal flexibility in workforce deployment, and, second, they constitute an effective device to deliver training and develop skills.     

Land,territory and commons: voices and visions from the struggles

ABSTRACT

All over the world, financial capitalism and extractivism are appropriating land as if it was nothing more than a commodity, a mere ‘factor’ of production that can be exploited to generate financial returns. Movements and activists are organizing, resisting, protecting and promoting life-giving visions against this continuous enclosure of living beings and paces: they use their bodies, laws, educational projects, histories and visions to regain control over territory as a political space, self-determine and create solidarities. In the act resistance, they are the target of moral, physical and legal violence. They and their ideas are criminalized, disciplined, punished and in some cases exterminated. In this contribution, activists from the Basque Country, Guatemala, Kenya and the Six Nations and a group of academics get together to learn from each other, support the ongoing search for common vocabularies and identify possible milestones of a coordinated and international strategy for a life-enhancing future.