Testing in semiparametric models with interaction, with applications to gene–environment interactions

Summary.  Motivated from the problem of testing for genetic effects on complex traits in the presence of gene–environment interaction, we develop score tests in general semiparametric regression problems that involves Tukey style 1 degree-of-freedom form of interaction between parametrically and non-parametrically modelled covariates. We find that the score test in this type of model, as recently developed by Chatterjee and co-workers in the fully parametric setting, is biased and requires undersmoothing to be valid in the presence of non-parametric components. Moreover, in the presence of repeated outcomes, the asymptotic distribution of the score test depends on the estimation of functions which are defined as solutions of integral equations, making implementation difficult and computationally taxing. We develop profiled score statistics which are unbiased and asymptotically efficient and can be performed by using standard bandwidth selection methods. In addition, to overcome the difficulty of solving functional equations, we give easy interpretations of the target functions, which in turn allow us to develop estimation procedures that can be easily implemented by using standard computational methods. We present simulation studies to evaluate type I error and power of the method proposed compared with a naive test that does not consider interaction. Finally, we illustrate our methodology by analysing data from a case–control study of colorectal adenoma that was designed to investigate the association between colorectal adenoma and the candidate gene NAT2 in relation to smoking history.     

Robustness of tests for directional mean

In this paper we study the robustness of the likelihood ratio, circular mean and circular trimmed mean test functionals in the context of tests of hypotheses regarding the mean direction of circular normal and wrapped normal distributions. We compute the level and power breakdown properties of the three test functionals and compare them. We find that the circular trimmed mean test functional has the best robustness properties for both the above-mentioned distributions. The level and power properties of the test statistics corresponding to these functionals are also studied. Two examples with real data are given for illustration. We also consider the problem of testing the mean direction of the von-Mises–Fisher distribution on the unit sphere and explore the robustness properties of the spherical mean direction and likelihood ratio test functionals.     

A NOTE ON VARIANCE ESTIMATION FOR THE GENERALIZED REGRESSION PREDICTOR

The generalized regression (GREG) predictor is used for estimating a finite population total when the study variable is well‐related to the auxiliary variable. In 1997, Chaudhuri & Roy provided an optimal estimator for the variance of the GREG predictor within a class of non‐homogeneous quadratic estimators (H) under a certain superpopulation model M. They also found an inequality concerning the expected variances of the estimators of the variance of the GREG predictor belonging to the class H under the model M. This paper shows that the derivation of the optimal estimator and relevant inequality, presented by Chaudhuri & Roy, are incorrect.     

SB-robustness of directional mean for circular distributions

In this paper we study the robustness of the directional mean (a.k.a. circular mean) for different families of circular distributions. We show that the directional mean is robust in the sense of finite standardized gross error sensitivity (SB-robust) for the following families: (1) mixture of two circular normal distributions, (2) mixture of wrapped normal and circular normal distributions and (3) mixture of two wrapped normal distributions. We also show that the directional mean is not SB-robust for the family of all circular normal distributions with varying concentration parameter. We define the circular trimmed mean and prove that it is SB-robust for this family. In general the property of SB-robustness of an estimator at a family of probability distributions is dependent on the choice of the dispersion measure. We introduce the concept of equivalent dispersion measures and prove that if an estimator is SB-robust for one dispersion measure then it is SB-robust for all equivalent dispersion measures. Three different dispersion measures for circular distributions are considered and their equivalence studied.     

Sampling on Two Occasions With Varying Probabilities

In estimating the current value of a finite population total from two consecutive surveys with samples chosen with varying probabilities, we demonstrate through examples the intuitively expected superiority of strategies when current unmatched samples are chosen from the complements of the current matched sub-samples, over the usual ones where these are chosen from the entire population.     

TWO-STAGE SAMPLING OVER TWO OCCASIONS

We propose a general sampling strategy for estimating a finite population total for the current occasion based on a two-stage sampling scheme adopted on the current and a previous occasion. This is in generalization of sampling schemes considered earlier by, among others, Singh (1968), Abraham, Khosla & Kathuria (1969), Singh & Kathuria (1969) and Kathuria (1975). Applications of the general strategy in specific situations are illustrated.     

Estimation of population mean in presence of random non response in two-stage cluster sampling

The present investigation addresses the problem of estimating a finite population mean in two-phase cluster sampling in presence of random non response situations. Utilizing information on an auxiliary variable, regression type estimators has been proposed. Effective imputation techniques have been suggested to deal with the random non response situations. The properties of the proposed estimation strategies have been studied for different cases of random non response situations in practical surveys. The superiority of the suggested methodology over the natural sample mean estimator of population mean has been established through empirical studies carried over the data sets of natural population and artificially generated population.     

Partial orders with respect to continuous covariates and tests for the proportional hazards model

Several omnibus tests of the proportional hazards assumption have been proposed in the literature. In the two-sample case, tests have also been developed against ordered alternatives like monotone hazard ratio and monotone ratio of cumulative hazards. Here we propose a natural extension of these partial orders to the case of continuous and potentially time varying covariates, and develop tests for the proportional hazards assumption against such ordered alternatives. The work is motivated by applications in biomedicine and economics where covariate effects often decay over lifetime. The proposed tests do not make restrictive assumptions on the underlying regression model, and are applicable in the presence of time varying covariates, multiple covariates and frailty. Small sample performance and an application to real data highlight the use of the framework and methodology to identify and model the nature of departures from proportionality.     

ON ESTIMATING THE MEAN OF A FINITE POPULATION SAMPLED ON TWO OCCASIONS WITH VARYING PROBABILITIES

The problem considered is one of estimating the current value of a finite population mean from two samples selected with varying probabilities on the current and a previous occasion. Following the generalized least squares approach of Gurney and Daly (1965) we extend the works of Sin& (1968) and others to obtain two sampling strategies which are respectively more efficient than the ones suggested earlier by Raj (1965) and Chotai (1974).