A comparison of random balance and two-stage group screening designs: A case study

In this paper we focus on the problem of supersaturated (fewer runs than factors) screening experiments. We consider two major types of designs which have been proposed in this situ¬ation: random balance and two-stage group screening. We discuss the relative merits and demerits of each strategy. In addition, we compare the performance of these strategies by means of a case study in which 100 factors are screened in 20,42,62, and 84 runs.     

Asymptotic equivalence of the harrell-davis median estimator and the sample median

This paper presents an asymptotic equivalence result with a sharp rate of convergence forthe sample median and the Harrell-Davis median estimator. The consequences of this result are discussed.     

A note on the satterthwaite confidence interval for a variance

When using a Satterthwaite chi-squared approximation, it is generally thought that the approximation is satisfactory when it is applied to a positive linear combination of mean squares. In this note, we describe how the Williams - Tukey idea for getting a confidence interval for the among groups variance in a random one-way model can be incorporated into Satterthwaite’s procedure for getting a confidence interval for a variance. This adjusted Satterthwaite procedure insures that his chi-squared approximation is always applied to positive linear combinations of mean squares. A small simulation is included which suggests that the adjustment to the Satterthwaite procedure is effective.     

Estimating the discovery rate in a continuous time recapture model

We consider a family of marked Poisson process models for the discovery of distinct errors in a computer program and also for sampling, in continu-ous time, a population containing an unknown number of distinct biological species. Captures (selections or discoveries) are assumed to occur at a con-stant rate, each event consisting of the discovery of a distinct process (error or species) or the recurrence of a previously discovered process. Using a generalization of Nayak’s (1988) model we derive confidence limits for the discovery rate. The limits are based on the asymptotic distribution of a scaled logarithmic function of the maximum likelihood estimator.     

Recovery of inter-block information: extensions in a two variance component model

For a two variance component mixed linear model, it is shown that under suitable conditions there exists a nonlinear unbiased estimator that is better than a best linear unbiased estimator defined with respect to a given singular covariance matrix. It is also shown how this result applies to improving on intra-block estimators and on estimators like the unweighted means estimator in a random one-way model.     

H-likelihood: problems and solutions

In recent issues of this journal it has been asserted in two papers that the use of h-likelihood is wrong, in the sense of giving unsatisfactory estimates of some parameters for binary data (Kuk and Cheng, 1999; Waddington and Thompson, 2004) or theoretically unsound (Kuk and Cheng, 1999). We wish to refute both these assertions.     

On the Breslow–Holubkov estimator

Breslow and Holubkov (J Roy Stat Soc B 59:447–461 1997a) developed semiparametric maximum likelihood estimation for two-phase studies with a case–control first phase under a logistic regression model and noted that, apart for the overall intercept term, it was the same as the semiparametric estimator for two-phase studies with a prospective first phase developed in Scott and Wild (Biometrica 84:57–71 1997). In this paper we extend the Breslow–Holubkov result to general binary regression models and show that it has a very simple relationship with its prospective first-phase counterpart. We also explore why the design of the first phase only affects the intercept of a logistic model, simplify the calculation of standard errors, establish the semiparametric efficiency of the Breslow–Holubkov estimator and derive its asymptotic distribution in the general case.     

Thinking possibilistically in a probabilistic world

We cannot live on the knife edge of disaster all the time. We cannot even think about disastrous extremes with any clarity, says Lee Clarke . For 300 years we have equated thinking probabilistically with thinking rationally, but is that enough for thinking about terrorism, air crashes—or even God?     

Generalized inferences on the common mean vector of several multivariate normal populations

The hypothesis testing and confidence region are considered for the common mean vector of several multivariate normal populations when the covariance matrices are unknown and possibly unequal. A generalized confidence region is derived using the concepts of generalized method based on the generalized p$p$-value. The generalized confidence region is illustrated with two numerical examples. The merits of the proposed method are numerically compared with those of existing methods with respect to their expected area or expected d-dimensional volumes and coverage probabilities under different scenarios.