Neural mechanisms of language development in infancy

Understanding the neural processes underpinning individual differences in early language development is of increasing interest, as it is known to vary in typical development and to be quite heterogeneous in neurodevelopmental conditions. However, few studies to date have tested whether early brain measures are indicative of the developmental trajectory of language, as opposed to language outcomes at specific ages. We combined recordings from two longitudinal studies, including typically developing infants without a family history of autism, and infants with increased likelihood of developing autism (infant-siblings) (N = 191). Electroencephalograms (EEG) were recorded at 6 months, and behavioral assessments at 6, 12, 18, 24 and 36 months of age. Using a growth curve model, we tested whether absolute EEG spectral power at 6 months was associated with concurrent language abilities, and developmental change in language between 6 and 36 months. We found evidence of an association between 6-month alpha-band power and concurrent, but not developmental change in, expressive language ability in both infant-siblings and control infants. The observed association between 6-month alpha-band power and 6-month expressive language was not moderated by group status, suggesting some continuity in neural mechanisms.     

Non parametric Bayesian analysis of the two-sample problem with censoring

Testing for differences between two groups is a fundamental problem in statistics, and due to developments in Bayesian non parametrics and semiparametrics there has been renewed interest in approaches to this problem. Here we describe a new approach to developing such tests and introduce a class of such tests that take advantage of developments in Bayesian non parametric computing. This class of tests uses the connection between the Dirichlet process (DP) prior and the Wilcoxon rank sum test but extends this idea to the DP mixture prior. Here tests are developed that have appropriate frequentist sampling procedures for large samples but have the potential to outperform the usual frequentist tests. Extensions to interval and right censoring are considered and an application to a high-dimensional data set obtained from an RNA-Seq investigation demonstrates the practical utility of the method.     

Detection and management of mood disorders in the maternity setting: The Australian Clinical Practice Guidelines

BackgroundMood disorders arising in the perinatal period (conception to the first postnatal year), occur in up to 13% of women. The adverse impact of mood disorders on mother, infant and family with potential long-term consequences are well documented. There is a need for clear, evidence-based, guidelines for midwives and other maternity care providers.AimTo describe the process undertaken to develop the Australian Clinical Practice Guidelines for Depression and Related Disorders in the Perinatal Period and to highlight the key recommendations and their implications for the maternity sector.MethodUsing NHMRC criteria, a rigorous systematic literature review was undertaken synthesising the evidence used to formulate graded guideline recommendations. Where there was insufficient evidence for recommendations, Good Practice Points were formulated. These are based on lower quality evidence and/or expert consensus.FindingsThe quality of the evidence was good in regards to the use of the Edinburgh Postnatal Depression Scale and psychological interventions, but limited as regards medication use and safety perinatally. Recommendations were made for staff training in psychosocial assessment; universal screening for depression across the perinatal period; and the use of evidence based psychological interventions for mild to moderate depression postnatally. Good Practice Points addressed the use of comprehensive psychosocial assessment – including risk to mother and infant, and consideration of the mother–infant interaction – and gave advice around the use and safety of psychotropic medications in pregnancy and breastfeeding. In contrast to their international counterparts, the Australian guidelines emphasize a more holistic, woman and family centred approach to the management of mental health and mood disorders in the perinatal setting.ConclusionThe development of these Guidelines is a first step in translating evidence into practice and providing Australian midwives and other maternity care providers with clear guidance on the psychosocial management of women and families.     

原住民治理的宪政构架

在如何理解澳大利亚政府的宪政构架上,需要一个观念转变。这个转变的基础,是理解原住民治理的存在及其在澳大利亚政治组织各个层面的实践,以及澳大利亚州的正式制度已暗中接纳各种形式的原住民治理。澳大利亚的联邦主义经验意味着理解这种转变很容易做到。当联邦和州的原住民政策最终和支持它们的治理构架一样强大时,这一转变必定出现。