Estimating the parameters of a truncated weibull distribution

The problem of nonexistence of the maximum likelihood estimators (m.l.e.) with positive probability is investigated for the truncated Weibull distribution. Similar nonexistence of the m.l.e. is known for some other distributions such as truncated exponential, truncated normal, and one parameter truncated gamma. Modified likelihood estimators, which exist with probability one, are given and compared with the m.l.e.     

Flexibility or Cost Saving? Sourcing Decisions with Two Suppliers

This article studies a decentralized supply chain in which there are two suppliers and a single buyer. One supplier offers the quantity flexibility (QF) contract to the buyer, while the other offers the cheaper price. Under the QF contract, the buyer does not assume full responsibility for the forecast, yet the supplier guarantees the availability of the forecasted quantity with additional buffer inventory. On the other hand, the price‐only contract places full inventory burden on the buyer, but with a cheaper price. We study this problem from the buyer's perspective and solve for the buyer's optimal procurement and forecasting decisions. We identify areas where flexibility and cheaper price have an advantage, one over the other. Our results indicate that the buyer significantly benefits from having multiple sources of supply. We also find that, from the system's standpoint, a multisupplier system may outperform a single‐supplier supply chain under certain conditions. Interestingly, we observe that providing too much flexibility may benefit the low‐price supplier rather than benefiting the QF supplier. We discuss the managerial implications and provide directions for future research opportunities.     

Propensity score matched augmented controls in randomized clinical trials: A case study

Existing statutes in the United States and Europe require manufacturers to demonstrate evidence of effectiveness through the conduct of adequate and well‐controlled studies to obtain marketing approval of a therapeutic product. What constitutes adequate and well‐controlled studies is usually interpreted as randomized controlled trials (RCTs). However, these trials are sometimes unfeasible because of their size, duration, cost, patient preference, or in some cases, ethical concerns. For example, RCTs may not be fully powered in rare diseases or in infections caused by multidrug resistant pathogens because of the low number of enrollable patients. In this case, data available from external controls (including historical controls and observational studies or data registries) can complement information provided by RCT. Propensity score matching methods can be used to select or “borrow” additional patients from the external controls, for maintaining a one‐to‐one randomization between the treatment arm and active control, by matching the new treatment and control units based on a set of measured covariates, ie, model‐based pairing of treatment and control units that are similar in terms of their observable pretreatment characteristics. To this end, 2 matching schemes based on propensity scores are explored and applied to a real clinical data example with the objective of using historical or external observations to augment data in a trial where the randomization is disproportionate or asymmetric.     

Shortest confidence and prediction intervals for the log-normal

We provide the shortest prediction interval for X, and the shortest confidence interval for the median of X, when X has the log-normal distribution for both the case σ², the variance of log X, known and unknown. Tables are given to assist the practitioner in constructing these intervals. A real-life example is provided to illustrate the results.     

Simple Approximation Algorithms for MAXNAESP and Hypergraph 2-colorability

Hypergraph 2-colorability, also known as set splitting, is a widely studied problem in graph theory. In this paper we study the maximization version of the same. We recast the problem as a special type of satisfiability problem and give approximation algorithms for it. Our results are valid for hypergraph 2-colorability, set splitting and MAX-CUT (which is a special case of hypergraph 2-colorability) because the reductions are approximation preserving. Here we study the MAXNAESP problem, the optimal solution to which is a truth assignment of the literals that maximizes the number of clauses satisfied. As a main result of the paper, we show that any locally optimal solution (a solution is locally optimal if its value cannot be increased by complementing assignments to literals and pairs of literals) is guaranteed a performance ratio of . This is an improvement over the ratio of attributed to another local improvement heuristic for MAX-CUT (C. Papadimitriou, Computational Complexity, Addison Wesley, 1994). In fact we provide a bound of for this problem, where k 3 is the minimum number of literals in a clause. Such locally optimal algorithms appear to subsume typical greedy algorithms that have been suggested for problems in the general domain of satisfiability. It should be noted that the NAESP problem where each clause has exactly two literals, is equivalent to MAX-CUT. However, obtaining good approximation ratios using semi-definite programming techniques (M. Goemans and D.P. Williamson, in Proceedings of the 26th Annual ACM Symposium on Theory of Computing, 1994a, pp. 422–431) appears difficult. Also, the randomized rounding algorithm as well as the simple randomized algorithm both (M. Goemans and D.P. Williamson, SIAM J. Disc. Math, vol. 7, pp. 656–666, 1994b) yield a bound of for the MAXNAESP problem. In contrast to this, the algorithm proposed in this paper obtains a bound of for this problem.     

Principled leveraging of external data in the evaluation of diagnostic devices via the propensity score-integrated composite likelihood approach

In the area of diagnostics, it is common practice to leverage external data to augment a traditional study of diagnostic accuracy consisting of prospectively enrolled subjects to potentially reduce the time and/or cost needed for the performance evaluation of an investigational diagnostic device. However, the statistical methods currently being used for such leveraging may not clearly separate study design and outcome data analysis, and they may not adequately address possible bias due to differences in clinically relevant characteristics between the subjects constituting the traditional study and those constituting the external data. This paper is intended to draw attention in the field of diagnostics to the recently developed propensity score-integrated composite likelihood approach, which originally focused on therapeutic medical products. This approach applies the outcome-free principle to separate study design and outcome data analysis and can mitigate bias due to imbalance in covariates, thereby increasing the interpretability of study results. While this approach was conceived as a statistical tool for the design and analysis of clinical studies for therapeutic medical products, here, we will show how it can also be applied to the evaluation of sensitivity and specificity of an investigational diagnostic device leveraging external data. We consider two common scenarios for the design of a traditional diagnostic device study consisting of prospectively enrolled subjects, which is to be augmented by external data. The reader will be taken through the process of implementing this approach step-by-step following the outcome-free principle that preserves study integrity.     

'We Got to Figure it Out': Information-sharing and Siblings' Negotiations of Conflicts of Interests

Given the importance of mutual understanding for constructive conflict resolution, this study investigated the influence of information-sharing on siblings faced with conflicts of interests. Thirty-two sibling dyads (ages 4.5 to 8) participated. Siblings were asked to negotiate the division of five toys between themselves. Half of the pairs first shared information on which toys they wanted and why. Results indicated that information-sharing increased children's knowledge of one another's interests, the likelihood of achieving maximally beneficial outcomes, and the involvement of younger siblings in problem-solving.     

Regulation of migrant entrepreneurship: The strained conjunction of laws,policies and practices

We are struck by a curious paradox: the flourishing discourse on migrant entrepreneurship is replete with references to the regulatory environment; yet the precise ways in which regulations exert influence is rarely spelt out. This task is all the more urgent because policymakers are alighting on the fact that migrants often turn to self-employment to make their way in destination societies. Yet, the extent to which regulations – comprising laws and governmental and non-governmental policy measures and practices – is poorly understood. This special section aims at filling this gap by adopting a theoretically informed analytical perspective to understand the role of regulation in migrant entrepreneurship. Articles in this special section analyse the nature of laws, policies and practices, the factors of success/failure of these, the role of governmental and non-governmental actors, and the effect of different welfare regimes and governance conditions.     

Scheduling with Sequencing Flexibility*

This study examines the effects of sequencing flexibility on the performance of rules used to schedule operations in manufacturing systems. The findings show that taking advantage of even low levels of sequencing flexibility in the set of operations required to do a job results in substantial improvement in the performance of scheduling rules with respect to mean flowtime. Differences in the mean flowtime measure for various rules also diminish significantly with increasing sequencing flexibility. Performance improvements additionally result for such due-date related performance measures as mean tardiness and the proportion of jobs tardy. At high levels of sequencing flexibility, some nonparametric scheduling rules outperform the shortest processing time rule in terms of the mean flowtime criterion. Rules based on job due dates also outperform rules based on operation milestones in terms of tardiness related criteria at high levels of sequencing flexibility. The implications of these findings for the design of manufacturing systems and product design are noted.     

Risk-Constrained Information Choice

Ahituv and Wand [1] applied an information economics model to the problem of making information choices using two decision criteria: expected (monetary) payoff and expected risk. Using risk-constrained optimization, they derived a solution in which the use of information is randomized by means of a mixed decision strategy. Although this solution is undominated when the expected payoff/expected risk trade-off boundary is convex, it may be dominated when the boundary is not convex. To avoid such dominance, it is necessary to adjust their solution by randomizing the choice of information rather than its use. For any feasible level of expected risk, this will yield an expected payoff equal to or greater than their solution produces and will always result in an undominated expected payoff/expected risk combination.