蛋白组学方法应用于人肺癌组织蛋白表达的研究

采用蛋白组学方法,利用4例中国肺癌患者的切除肺癌组织测定了磷癌(SQCLC)的蛋白表达 从双向电泳(2-DEgel)切下53个点,49个蛋白与数据库搜索结果吻合。在鉴定的24个蛋白中,17个蛋白有报道是与肺癌相关的蛋白其7个蛋白与人类其它癌症相关。所建立的蛋白组学方法能够用于建立一种基于组织的化验方法,发现肺癌患者组织中表达的蛋白标记物以用于癌症的分子学诊断。     

Multivariate distributions defined in terms of contours

The paper deals with the problem of using contours as the basis for defining probability distributions. First, the most general probability densities with given contours are obtained and the particular cases of circular and elliptical contours are dealt with. It is shown that the so-called elliptically contoured distributions do not include all possible cases. Next, the case of contours defined by polar coordinates is analyzed including its simulation and parameter estimation. Finally, the case of cumulative distribution functions with given contours is discussed. Several examples are used for illustrative purposes.     

Examples of the use of an equivalence theorem in constructing optimum experimental designs for random-effects nonlinear regression models

The problem considered is that of finding an optimum measurement schedule to estimate population parameters in a nonlinear model when the patient effects are random. The paper presents examples of the use of sensitivity functions, derived from the General Equivalence Theorem for D-optimality, in the construction of optimum population designs for such schedules. With independent observations, the theorem applies to the potential inclusion of a single observation. However, in population designs the observations are correlated and the theorem applies to the inclusion of an additional measurement schedule. In one example, three groups of patients of differing size are subject to distinct schedules. Numerical, as opposed to analytical, calculation of the sensitivity function is advocated. The required covariances of the observations are found by simulation.     

后现代国际私法理论探微

后现代国际私法理论是当代国际私法学的一种新兴理论 ,本文从其哲学渊源———后现代主义出发 ,评析其基本主张及其对当代国际私法发展的影响 ,并结合中国的具体理论与实践 ,探讨中国国际私法学对该理论的应对模式。     

小额信贷之违约概率模型:特别考虑异质性

在新巴塞尔资本协议(New Basel Capital Accord)对金融全球化的冲击及金融机构改善资产质量及合并政策的影响下,我国台湾地区金融业进入激烈合并竞争的时代.许多银行颇受降低逾放比率及增加净值报酬率与资产报酬率两难之困扰.消费性信用贷款产品利差大、风险分散,是金融机构授信经营极重要的产品.实证结果显示,采用世代研究(cohort study)建立之模型对样本数据之拟合程度较个案对照研究法(case-control study)的解释变异量为佳,且较符合新巴塞尔资本协议规定及科学程序.虽然Logistic 回归模型在建立逾期概率模型上广泛地被使用,但要求存在于同构型的变异数Var=np(1-p)假设上,且在数据分析上常因为出现变异数之异质性问题,故可采用调整变异数异质性之方法.     

黎族文学试论

本文对黎族文学从多层面加以论述。     

俄罗斯东正教的社会整合与道德教化作用研究

俄罗斯是一个有着深刻宗教情结的民族.东正教作为文化现象和意识形态,深深根植于俄罗斯民众的意识里,浓浓地融入俄罗斯民族的精神中,深刻地影响着俄国的历史与现实.为实现国家统一并加强皇权,以君权神授为宗旨的基督教作为最有力的思想武器被罗斯统治者"请入"罗斯.至此,无论是在鞑靼蒙古人入侵时期,还是在第一、二次卫国战争等俄苏历史的紧要关头,俄罗斯东正教均发挥了其社会整合与道德教化作用,并在促进国家统一、弘扬爱国主义传统、凝聚民族精神、规范民众道德和维护社会稳定等方面做出了积极而重要的历史贡献.     

《汉语大字典》书证疏误举例

《汉语大字典》在义项的书证方面存在一些疏误,内容涉及书证欠妥、书证有误、引文失误、一例两用等问题。     

Form Perception of Partly Occluded Shapes in 4‐Month‐Old Infants

Two habituation experiments were conducted to investigate how 4‐month‐old infants perceive partly occluded shapes. In the first experiment, we presented a simple, partly occluded shape to the infants until habituation was reached. Then we showed either a probable completion (one that would be predicted on the basis of both local and global cues) or an improbable completion. Longer looking times were found for the improbably completed shape (compared to probable and control conditions), suggesting that the probable shape was perceived during partial occlusion. In the second experiment, infants were habituated to more ambiguous partly occluded shapes, where local and global cues would result in different completions. For adults, the percept of these shapes is usually dominated by global influences. However, after habituation the infants looked longer at the globally completed shapes. These results suggest that by the age of 4 months, infants are able to infer the perceptual completion of partly occluded shapes, but for more ambiguous shapes, this completion seems to be dominated by local influences.