An Empirical Approach to Sufficient Similarity: Combining Exposure Data and Mixtures Toxicology Data

When assessing risks posed by environmental chemical mixtures, whole mixture approaches are preferred to component approaches. When toxicological data on whole mixtures as they occur in the environment are not available, Environmental Protection Agency guidance states that toxicity data from a mixture considered “sufficiently similar” to the environmental mixture can serve as a surrogate. We propose a novel method to examine whether mixtures are sufficiently similar, when exposure data and mixture toxicity study data from at least one representative mixture are available. We define sufficient similarity using equivalence testing methodology comparing the distance between benchmark dose estimates for mixtures in both data‐rich and data‐poor cases. We construct a “similar mixtures risk indicator”(SMRI) (analogous to the hazard index) on sufficiently similar mixtures linking exposure data with mixtures toxicology data. The methods are illustrated using pyrethroid mixtures occurrence data collected in child care centers (CCC) and dose‐response data examining acute neurobehavioral effects of pyrethroid mixtures in rats. Our method shows that the mixtures from 90% of the CCCs were sufficiently similar to the dose‐response study mixture. Using exposure estimates for a hypothetical child, the 95th percentile of the (weighted) SMRI for these sufficiently similar mixtures was 0.20 (i.e., where SMRI <1, less concern; >1, more concern).     

Business patterns within telecommunications

The global telecommunications changed from a number of co-operating national monopolies offering a restricted range of services to a competitive, growing market with players of many types and sizes, offering a large range of services. How can vertically integrated incumbents align themselves and their systems to best compete in this environment? Business patterns and enterprise modelling offer a tool to model a large organization as a number of smaller enterprises that can compete with and co-operate with smaller specialist players in the market. In order to identify enterprises, this paper proposes that there are only a limited number of types of enterprise (manufacturer, service supplier, reseller, that these enterprise types can only interact in a limited number of ways (component supply, aggregation supply, resell supply, trading, end-supply and commission). With the use of examples, this paper illustrates these types of enterprise and enterprise relationships, and how they can be combined to build both internal and external supply chains, and discusses some of the conclusions that can be drawn from this analysis.     

Privatizing Australian Airports: Ownership, Divestment and Financial Performance

This article addresses the performance of the three largest Australian airports following their privatization. The airports represent cases of divestment of government business enterprises into privately-owned businesses each with differing ownership arrangements. The performances of the privatized airports are considered using financial data obtained from general purpose financial reports of the entities. There are significant implications for future divestment policies, including the value of divestment as a policy response in uncompetitive environments, the use of particular infrastructure investment models, and the nature of the linkage between ownership structure and financial performance.     

Managing Technology for Competitive Advantage : Editors

This paper discusses an example of community action mounted in a rural region of New South Wales, Australia, in response to proposals by the State Government to rationalise agricultural research stations operated by the Department of Primary Industries. Informed by a Foucaultian understanding of power and the concept of governmentality, neoliberalism is theorised as being the broad governmental context in which rationalisation proposals were put forward. Recent literature drawing on this theoretical perspective has emphasised that neoliberalism is enacted through a relationship of power, and is not monolithic or inevitable. Neoliberalism is always negotiated by those seeking to govern and those who are the object of such governmental actions. This paper analyses how plans to rationalise publicly funded agricultural research stations were opposed by those seeking to keep research facilities open in the case study area. The paper discusses the methods and scope of community action and, drawing on interviews, identifies a series of discourses articulated by campaigners. Non-local actors were depicted as uncaring and insensitive. In contrast, campaigners discussed the emergence of a ‘city-country divide’ in domestic politics; the need for specialist agricultural knowledge given the region's unique geographical location; and local impacts of an economic, social and emotional nature. Central were discourses of maintaining community, tradition, and continuity in unique local places defined by their climate, biophysical environment and economy. These were ‘counter-geographies’ that sought (successfully, it would transpire) to disrupt the state's imagined geography of a homogenous and flexible administrative space in which research services could be relocated wherever most efficient. Important too were embodied resistances to the way rural industries and people were subjected. Campaigners refused to accept preferred codes of neoliberal behaviour (particularly mobility and rationality) and instead demanded respect for their careers, families and communities. Important considerations are suggested for further research on impacts and negotiations of neoliberalism. This study particularly highlights the successes—as well as contradictions and limitations—of arguments that construct rural places as socialised, unique and unfairly treated (by governments), in opposition to metropolitan dominance and ‘placeless’ neoliberalism.     

Counter-geographies: The campaign against rationalisation of agricultural research stations in New South Wales, Australia

This paper discusses an example of community action mounted in a rural region of New South Wales, Australia, in response to proposals by the State Government to rationalise agricultural research stations operated by the Department of Primary Industries. Informed by a Foucaultian understanding of power and the concept of governmentality, neoliberalism is theorised as being the broad governmental context in which rationalisation proposals were put forward. Recent literature drawing on this theoretical perspective has emphasised that neoliberalism is enacted through a relationship of power, and is not monolithic or inevitable. Neoliberalism is always negotiated by those seeking to govern and those who are the object of such governmental actions. This paper analyses how plans to rationalise publicly funded agricultural research stations were opposed by those seeking to keep research facilities open in the case study area. The paper discusses the methods and scope of community action and, drawing on interviews, identifies a series of discourses articulated by campaigners. Non-local actors were depicted as uncaring and insensitive. In contrast, campaigners discussed the emergence of a ‘city-country divide’ in domestic politics; the need for specialist agricultural knowledge given the region's unique geographical location; and local impacts of an economic, social and emotional nature. Central were discourses of maintaining community, tradition, and continuity in unique local places defined by their climate, biophysical environment and economy. These were ‘counter-geographies’ that sought (successfully, it would transpire) to disrupt the state's imagined geography of a homogenous and flexible administrative space in which research services could be relocated wherever most efficient. Important too were embodied resistances to the way rural industries and people were subjected. Campaigners refused to accept preferred codes of neoliberal behaviour (particularly mobility and rationality) and instead demanded respect for their careers, families and communities. Important considerations are suggested for further research on impacts and negotiations of neoliberalism. This study particularly highlights the successes—as well as contradictions and limitations—of arguments that construct rural places as socialised, unique and unfairly treated (by governments), in opposition to metropolitan dominance and ‘placeless’ neoliberalism.     

Seeing the woods — statistics for the very young

If you go down to the woods today … you're sure of a big statistical experience. You might run into Chris Du Feu giving 9-year-olds their first lesson in statistics. Tasks for the teacher? One, clear nettles; two, make sure that leaves will stay firmly stuck in place on the bar-chart…     

Do self‐assessment and self‐directed support undermine traditional social work with disabled people?

In recent years, self‐assessment and self‐directed support have become mainstream options within disability services. The Disabled People’s Movement has advocated the need for such change for a long time but this has been persistently resisted by many social workers. In this article, it will be argued that both self‐assessment and self‐directed support undermine traditional social work and that social workers need to begin to work alongside disabled people, rather than ‘for’ disabled people, in order to achieve substantial system change.     

FATHERS’ USE OF LEAVE IN AUSTRALIA

This paper examines Australian fathers’ use of leave at the time of the birth of a child, drawing on data from The Parental Leave in Australia Survey, conducted in 2005, and a subsequent organizational case study. Our analysis shows that although most Australian fathers take some leave for parental purposes, use of formally designated paternity or parental leave is limited. This is unsurprising given the Australian policy framework, which lacks legislative provision for paid paternity or parental leave, and does not require any of the shared unpaid parental-leave entitlement to be reserved for fathers. Use of leave is shown to be influenced primarily by fathers’ employment characteristics, with those working in small organizations or non-permanent positions least likely to utilize paternity or other forms of leave. Overall, the analysis suggests that improvements in the policy framework would increase Australian fathers’ propensity to take parental leave, but highlights barriers to usage associated with labour market divisions and career pressures that will not be solved solely by the adoption of more progressive leave policies.