The exponentiated reduced Kies distribution: Properties and applications

Here we consider an exponentiated version of the reduced Kies distribution and discuss some of its properties. The parameters of the distribution are estimated by the method of maximum likelihood and illustrated with the help of certain real-life data sets. Asymptotic behavior of the maximum likelihood estimators of the parameters of the distribution is also studied by using certain simulated data sets.     

Confidence Corridors for Multivariate Generalized Quantile Regression

We focus on the construction of confidence corridors for multivariate nonparametric generalized quantile regression functions. This construction is based on asymptotic results for the maximal deviation between a suitable nonparametric estimator and the true function of interest, which follow after a series of approximation steps including a Bahadur representation, a new strong approximation theorem, and exponential tail inequalities for Gaussian random fields. As a byproduct we also obtain multivariate confidence corridors for the regression function in the classical mean regression. To deal with the problem of slowly decreasing error in coverage probability of the asymptotic confidence corridors, which results in meager coverage for small sample sizes, a simple bootstrap procedure is designed based on the leading term of the Bahadur representation. The finite-sample properties of both procedures are investigated by means of a simulation study and it is demonstrated that the bootstrap procedure considerably outperforms the asymptotic bands in terms of coverage accuracy. Finally, the bootstrap confidence corridors are used to study the efficacy of the National Supported Work Demonstration, which is a randomized employment enhancement program launched in the 1970s. This article has supplementary materials online.     

The Generalized Conditional Autoregressive Wishart Model for Multivariate Realized Volatility

It is well known that in finance variances and covariances of asset returns move together over time. Recently, much interest has been aroused by an approach involving the use of the realized covariance (RCOV) matrix constructed from high-frequency returns as the ex-post realization of the covariance matrix of low-frequency returns. For the analysis of dynamics of RCOV matrices, we propose the generalized conditional autoregressive Wishart (GCAW) model. Both the noncentrality matrix and scale matrix of the Wishart distribution are driven by the lagged values of RCOV matrices, and represent two different sources of dynamics, respectively. The GCAW is a generalization of the existing models, and accounts for symmetry and positive definiteness of RCOV matrices without imposing any parametric restriction. Some important properties such as conditional moments, unconditional moments, and stationarity are discussed. Empirical examples including sequences of daily RCOV matrices from the New York Stock Exchange illustrate that our model outperforms the existing models in terms of model fitting and forecasting.     

Prior specification of neighbourhood and interaction structure in binary Markov random fields

We formulate a prior distribution for the energy function of stationary binary Markov random fields (MRFs) defined on a rectangular lattice. In the prior we assign distributions to all parts of the energy function. In particular we define priors for the neighbourhood structure of the MRF, what interactions to include in the model, and for potential values. We define a reversible jump Markov chain Monte Carlo (RJMCMC) procedure to simulate from the corresponding posterior distribution when conditioned to an observed scene. Thereby we are able to learn both the neighbourhood structure and the parametric form of the MRF from the observed scene. We circumvent evaluations of the intractable normalising constant of the MRF when running the RJMCMC algorithm by adopting a previously defined approximate auxiliary variable algorithm. We demonstrate the usefulness of our prior in two simulation examples and one real data example.     

指数-威布尔分布参数贝叶斯估计的混合Gibbs算法

文章利用混合Gibbs算法分别在分组数据和定数截尾场合给出了指数-威布尔分布参数的贝叶斯估计,并进行了Monte-Carlo模拟.结果表明:在两种不完全数据场合,用混合Gibbs算法求指数-威布尔分布参数的贝叶斯估计,结果令人满意,该算法可行、稳定且精度高.     

Statistical modeling for Bayesian extrapolation of adult clinical trial information in pediatric drug evaluation

Children represent a large underserved population of “therapeutic orphans,” as an estimated 80% of children are treated off‐label. However, pediatric drug development often faces substantial challenges, including economic, logistical, technical, and ethical barriers, among others. Among many efforts trying to remove these barriers, increased recent attention has been paid to extrapolation; that is, the leveraging of available data from adults or older age groups to draw conclusions for the pediatric population. The Bayesian statistical paradigm is natural in this setting, as it permits the combining (or “borrowing”) of information across disparate sources, such as the adult and pediatric data. In this paper, authored by the pediatric subteam of the Drug Information Association Bayesian Scientific Working Group and Adaptive Design Working Group, we develop, illustrate, and provide suggestions on Bayesian statistical methods that could be used to design improved pediatric development programs that use all available information in the most efficient manner. A variety of relevant Bayesian approaches are described, several of which are illustrated through 2 case studies: extrapolating adult efficacy data to expand the labeling for Remicade to include pediatric ulcerative colitis and extrapolating adult exposure‐response information for antiepileptic drugs to pediatrics.     

Improving the detection of unusual observations in high‐dimensional settings

Multivariate control charts are used to monitor stochastic processes for changes and unusual observations. Hotelling's T² statistic is calculated for each new observation and an out‐of‐control signal is issued if it goes beyond the control limits. However, this classical approach becomes unreliable as the number of variables p approaches the number of observations n, and impossible when p exceeds n. In this paper, we devise an improvement to the monitoring procedure in high‐dimensional settings. We regularise the covariance matrix to estimate the baseline parameter and incorporate a leave‐one‐out re‐sampling approach to estimate the empirical distribution of future observations. An extensive simulation study demonstrates that the new method outperforms the classical Hotelling T² approach in power, and maintains appropriate false positive rates. We demonstrate the utility of the method using a set of quality control samples collected to monitor a gas chromatography–mass spectrometry apparatus over a period of 67 days.     

Pricing power options with a generalized jump diffusion

In this article, the valuation of power option is investigated when the dynamic of the stock price is governed by a generalized jump-diffusion Markov-modulated model. The systematic risk is characterized by the diffusion part, and the non systematic risk is characterized by the pure jump process. The jumps are described by a generalized renewal process with generalized jump amplitude. By introducing NASDAQ Index Model, their risk premium is identified respectively. A risk-neutral measure is identified by employing Esscher transform with two families of parameters, which represent the two parts risk premium. In this article, the non systematic risk premium is considered, based on which the price of power option is studied under the generalized jump-diffusion Markov-modulated model. In the case of a special renewal process with log double exponential jump amplitude, the accurate expressions for the Esscher parameters and the pricing formula are provided. By numerical simulation, the influence of the non systematic risk’s price and the index of the power options on the price of the option is depicted.     

Extended scaled prediction variance optimality for modified central composite design

Robust parameter designs (RPDs) enable the experimenter to discover how to modify the design of the product to minimize the effect due to variation from noise sources. The aim of this article is to show how this amount of work can be reduced under modified central composite design (MCCD). We propose a measure of extended scaled prediction variance (ESPV) for evaluation of RPDs on MCCD. Using these measures, we show that we can check the error or bias associated with estimating the model parameters and suggest the values of α recommended for MCCS under minimum ESPV.     

The performance of model averaged tail area confidence intervals

We investigate the exact coverage and expected length properties of the model averaged tail area (MATA) confidence interval proposed by Turek and Fletcher, CSDA, 2012, in the context of two nested, normal linear regression models. The simpler model is obtained by applying a single linear constraint on the regression parameter vector of the full model. For given length of response vector and nominal coverage of the MATA confidence interval, we consider all possible models of this type and all possible true parameter values, together with a wide class of design matrices and parameters of interest. Our results show that, while not ideal, MATA confidence intervals perform surprisingly well in our regression scenario, provided that we use the minimum weight within the class of weights that we consider on the simpler model.