Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method

The Escalation with Overdose Control (EWOC) design for cancer dose finding clinical trials is a variation of the Continual Reassessment Method (CRM) that was proposed to overcome the limitation of the original CRM of exposing patients to high toxic doses. The properties of EWOC have been studied to some extent, but some aspects of the design are not well studied, and its performance is not fully understood. Comparisons of the EWOC design to the most commonly used modified CRM designs have not yet been performed, and the advantages of EWOC over the modified CRM designs are unclear. In this paper, we assess the properties of the EWOC design and of the restricted CRM and some variations of these designs. We show that EWOC has several weaknesses that CRM does not have that make it impractical to use in its original formulation. We propose modified EWOC designs that address some of the weaknesses and that have some desirable statistical properties compared with the original EWOC design, the restricted CRM design, and the 3 + 3 design. However, their statistical properties are sensitive to correct specification of the prior distribution of their parameters and hence nevertheless will need to be used with some caution. The restricted CRM design is shown to have more stable performance across a wider family of dose‐toxicity curves than EWOC and therefore may be a preferable general choice in cancer clinical research.     

Ceremonial degradation of a doctoral candidate: An essay on the social situation of graduate student ethnographers and other inmates

The recruit comes into the establishment with a conception of himself made possible by certain stable social arrangements in his home world. Upon entrance, he is immediately stripped of the support provided by these arrangements. In the accurate language of some of the oldest total institutions, he begins a series of abasements, degradations, humiliations, and profanations of the self. His self is systematically, if often unintentionally, mortified. He begins some radical shifts in his moral career, a career composed of the progressive changes that occur in the beliefs that he has concerning himself and the significance of others. (Goffman 1961: 14) His research areas are Deviance and Social Control and Social Psychology     

‘Somebody Else's Roadmap’: Lived Experience of Maudsley and Family‐based Therapy for Adolescent Anorexia Nervosa

The Maudsley and more recent family‐based therapy manualised approaches are positioned by some as the gold standard, evidence‐based therapy for adolescent anorexia nervosa (AN). However, a significant proportion of adolescents and their families either discontinue this therapy and/or find that it simply does not work for them. These adolescents and families are under‐represented in the literature on therapeutic interventions for adolescent AN. This paper begins to address this gap with an in‐depth qualitative case study that explores the lived experience of Maudsley family therapy (MFT)/family‐based therapy (FBT) for one female adolescent (age 14 years) and her family over the period of 3 years (ages 11–14). Although initially handing over the responsibility for her eating was comforting and reinstated a sense of control in the family system, these experiences were not maintained. When she did not progress past the first phase of FBT, she and her family experienced the approach as blaming. She felt silenced and family alliances were weakened. This paper analyses how the family members negotiated and preserved their identities within this disabling context.     

Social network engineering and race in a police academy: A longitudinal analysis

This research examined an attempt to facilitate racial integration by populating squads (i.e., workgroups) in a police academy with mixes of recruits that reflected the racial demographics of the larger cohort. This was part of the social infrastructure of the academy. Additionally, a fixed seating arrangement was considered as a second element of academy infrastructure capable of impacting racial integration. We examined the consequences of these academy components over time with regard to race by combining ethnographic accounts with social network data collected throughout the academy and using a variety of network analytic tools. These consequences with regard to race were examined as a part of social network evolution. The academy's social arrangements did accelerate the creation of social knowledge of recruits about each other and the formation of friendship ties both within and between races. However, our results point to clear limitations to such infrastructural engineering and have implications for both recruitment to police academies and dealing with race. They shed light also on processes of homophily and group composition over time and have implications for studying social networks.     

Serious Leisure in the Home: Professional Quilters Negotiate Family Space

Although quilting has become more popular in the USA since its re‐emergence in 1976, with 15 per cent of households participating at the time of writing, quilting is still thought by many to be a frivolous, quaint or silly feminized activity. Those who quilt professionally, or for profit have difficulty legitimating their efforts as ‘real work’. Our focus is on one aspect of the quilting industry — professional quilters — and their negotiation of legitimacy for quilting work that is done in the home. We conduct secondary qualitative data analysis of 147 interviews of mostly women professional quilters from the Quilters' Save Our Stories Oral History Project. Professional quilters have more legitimacy and more claim to home‐based resources such as time and space than do amateur quilters but their work is still devalued as a gendered activity in the home. Despite achieving objective indicators of professional success (e.g., money, prizes and international recognition), professional quilters still have difficulty defending their home‐based employment activities and acquiring resources to carry it out.     

Asymptotic inference on a general measure of monotone dependence

Summary In this paper a class of measures of monotone dependence (concordance/discordance) for arbitrary (not necessarily continuous) bivariate distributions is considered. It is shown that the corresponding sampling index of concordance/discordance (which is the most natural estimator of the population index) converges in law to a normal distribution. A Berry-Esséen bound for its rate of convergence is given. Finally, a consistent estimator of the asymptotic variance of the sampling concordance/ discordance index is proposed. This last result is essential for constructing confidence intervals and testing hypotheses on the population measure of monotone dependence.     

Bootstrap approximations for Bayesian analysis of Geo/G/1 discrete-time queueing models

In this paper we consider a Bayesian nonparametric approach to the analysis of discrete-time queueing models. The main motivation consists in applications to telecommunications, and in particular to asynchronous transfer mode (ATM) systems. Attention is focused on the posterior distribution of the overflow rate. Since the exact distribution of such a quantity is not available in a closed form, an approximation based on “proper” Bayesian bootstrap is proposed, and its properties are studied. Some possible alternatives to proper Bayesian bootstrap are also discussed. Finally, an application to real data is provided.     

Some remarks on an admissibility condition

Summary In this note we deal with some admissibility conditions proved by G. B. Tranquilli to be sufficient in the class of unbiased estimators of finite population parameters and with respect to (w.r.t.) a quadratic loss function. We show that the same conditions:i) are sufficient for the admissibility of an unbiased estimator with any loss function;ii) imply hyperadmissibility with reference to a particular (critical) population of the. From this fact we deduce that, for a fixed critical population, there is at most one estimator, in the class of all unbiased estimator of a finite population parameter, which satisfies Tranquilli condition. This research was partially supported by a M.U.R.S.T. grant ?Metodi inferenziali basati sul ricampionamento?.