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911.
Jianing Di Daniel Wang H. Robert Brashear Vladimir Dragalin Michael Krams 《Pharmaceutical statistics》2016,15(2):109-122
In clinical trials, continuous monitoring of event incidence rate plays a critical role in making timely decisions affecting trial outcome. For example, continuous monitoring of adverse events protects the safety of trial participants, while continuous monitoring of efficacy events helps identify early signals of efficacy or futility. Because the endpoint of interest is often the event incidence associated with a given length of treatment duration (e.g., incidence proportion of an adverse event with 2 years of dosing), assessing the event proportion before reaching the intended treatment duration becomes challenging, especially when the event onset profile evolves over time with accumulated exposure. In particular, in the earlier part of the study, ignoring censored subjects may result in significant bias in estimating the cumulative event incidence rate. Such a problem is addressed using a predictive approach in the Bayesian framework. In the proposed approach, experts' prior knowledge about both the frequency and timing of the event occurrence is combined with observed data. More specifically, during any interim look, each event‐free subject will be counted with a probability that is derived using prior knowledge. The proposed approach is particularly useful in early stage studies for signal detection based on limited information. But it can also be used as a tool for safety monitoring (e.g., data monitoring committee) during later stage trials. Application of the approach is illustrated using a case study where the incidence rate of an adverse event is continuously monitored during an Alzheimer's disease clinical trial. The performance of the proposed approach is also assessed and compared with other Bayesian and frequentist methods via simulation. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
912.
Testing between hypotheses, when independent sampling is possible, is a well developed subject. In this paper, we propose hypothesis tests that are applicable when the samples are obtained using Markov chain Monte Carlo. These tests are useful when one is interested in deciding whether the expected value of a certain quantity is above or below a given threshold. We show non-asymptotic error bounds and bounds on the expected number of samples for three types of tests, a fixed sample size test, a sequential test with indifference region, and a sequential test without indifference region. Our tests can lead to significant savings in sample size. We illustrate our results on an example of Bayesian parameter inference involving an ODE model of a biochemical pathway. 相似文献
913.
Traceability and Risk Analysis Strategies for Addressing Counterfeit Electronics in Supply Chains for Complex Systems 下载免费PDF全文
Daniel DiMase Zachary A. Collier Jinae Carlson Robin B. Gray Jr. Igor Linkov 《Risk analysis》2016,36(10):1834-1843
Within the microelectronics industry, there is a growing concern regarding the introduction of counterfeit electronic parts into the supply chain. Even though this problem is widespread, there have been limited attempts to implement risk‐based approaches for testing and supply chain management. Supply chain risk management tends to focus on the highly visible disruptions of the supply chain instead of the covert entrance of counterfeits; thus counterfeit risk is difficult to mitigate. This article provides an overview of the complexities of the electronics supply chain, and highlights some gaps in risk assessment practices. In particular, this article calls for enhanced traceability capabilities to track and trace parts at risk through various stages of the supply chain. Placing the focus on risk‐informed decision making through the following strategies is needed, including prioritization of high‐risk parts, moving beyond certificates of conformance, incentivizing best supply chain management practices, adoption of industry standards, and design and management for supply chain resilience. 相似文献
914.
915.
Daniel F. Linder Jingjing Yin Haresh Rochani Hani Samawi Sanjay Sethi 《统计学通讯:理论与方法》2018,47(5):1181-1203
The article details a sampling scheme which can lead to a reduction in sample size and cost in clinical and epidemiological studies of association between a count outcome and risk factor. We show that inference in two common generalized linear models for count data, Poisson and negative binomial regression, is improved by using a ranked auxiliary covariate, which guides the sampling procedure. This type of sampling has typically been used to improve inference on a population mean. The novelty of the current work is its extension to log-linear models and derivations showing that the sampling technique results in an increase in information as compared to simple random sampling. Specifically, we show that under the proposed sampling strategy the maximum likelihood estimate of the risk factor’s coefficient is improved through an increase in the Fisher’s information. A simulation study is performed to compare the mean squared error, bias, variance, and power of the sampling routine with simple random sampling under various data-generating scenarios. We also illustrate the merits of the sampling scheme on a real data set from a clinical setting of males with chronic obstructive pulmonary disease. Empirical results from the simulation study and data analysis coincide with the theoretical derivations, suggesting that a significant reduction in sample size, and hence study cost, can be realized while achieving the same precision as a simple random sample. 相似文献
916.
The primary aim of market segmentation is to identify relevant groups of consumers that can be addressed efficiently by marketing or advertising campaigns. This paper addresses the issue whether consumer groups can be identified from background variables that are not brand-related, and how much personality vs. socio-demographic variables contribute to the identification of consumer clusters. This is done by clustering aggregated preferences for 25 brands across 5 different product categories, and by relating socio-demographic and personality variables to the clusters using logistic regression and random forests over a range of different numbers of clusters. Results indicate that some personality variables contribute significantly to the identification of consumer groups in one sample. However, these results were not replicated on a second sample that was more heterogeneous in terms of socio-demographic characteristics and not representative of the brands target audience. 相似文献
917.
Modeling U‐Shaped Exposure‐Response Relationships for Agents that Demonstrate Toxicity Due to Both Excess and Deficiency 下载免费PDF全文
Brittany Milton Patrick J. Farrell Nicholas Birkett Daniel Krewski 《Risk analysis》2017,37(2):265-279
Essential elements such as copper and manganese may demonstrate U‐shaped exposure‐response relationships due to toxic responses occurring as a result of both excess and deficiency. Previous work on a copper toxicity database employed CatReg, a software program for categorical regression developed by the U.S. Environmental Protection Agency, to model copper excess and deficiency exposure‐response relationships separately. This analysis involved the use of a severity scoring system to place diverse toxic responses on a common severity scale, thereby allowing their inclusion in the same CatReg model. In this article, we present methods for simultaneously fitting excess and deficiency data in the form of a single U‐shaped exposure‐response curve, the minimum of which occurs at the exposure level that minimizes the probability of an adverse outcome due to either excess or deficiency (or both). We also present a closed‐form expression for the point at which the exposure‐response curves for excess and deficiency cross, corresponding to the exposure level at which the risk of an adverse outcome due to excess is equal to that for deficiency. The application of these methods is illustrated using the same copper toxicity database noted above. The use of these methods permits the analysis of all available exposure‐response data from multiple studies expressing multiple endpoints due to both excess and deficiency. The exposure level corresponding to the minimum of this U‐shaped curve, and the confidence limits around this exposure level, may be useful in establishing an acceptable range of exposures that minimize the overall risk associated with the agent of interest. 相似文献
918.
Daniel Navon 《Theory and Society》2017,46(2):143-176
This article examines the way advertising was rationalized in the early twentieth-century United States. Drawing on a targeted archival comparison with the United Kingdom, I show how the extensive mobilization undertaken to legitimate and rationalize advertising, rather than changes in the techniques employed in the content of ads themselves, were seen by actors in the mid-1920s to explain most of the extraordinary advances made by American advertising. Building on that comparison, I show how American advertising was transformed, particularly around World War I, into a legitimate profession situated at the center of a network of expertise about consumers and their media. Under the banner of “truth in advertising” ads came to be regarded as a legitimate, rational, and sustained business investment, leading to an enormous increase in aggregate expenditures. I argue that future research should examine how this process fuelled mass media and contributed to the conditions for modern consumerism. 相似文献
919.
Daniel Giunti 《Journal of homosexuality》2017,64(4):523-537
In Italy, homosexual people are not allowed to perform donor insemination/surrogacy or adoption, thus they become parents mainly in the context of previous heterosexual relationships. The current study examines the experiences of 34 gay fathers and 32 lesbian mothers with children from a heterosexual relationship. Data on homosexuality awareness, reasons for marriage and parenthood, and the coming-out process to children were collected. Most participants reported not being aware of their homosexuality when they married and became parents. The most common reasons for marriage were “love” and “social expectancy,” whereas parenthood was motivated mainly by the “desire for children and family.” Most participants came out to at least one child and reported a positive reaction. The most cited benefit of coming out was “openness/not hiding anymore.” The results suggest that the lives of gay and lesbian parents are shaped by their sexual minority status as well as by societal heterosexism. 相似文献
920.
Daniel Weston 《Journal of Sociolinguistics》2015,19(5):671-687
Schneider's Dynamic Model of Postcolonial English Development (2007) suggests that distinct local identities and their associated varieties of English emerge as a result of British colonization, and reach maturity only when ties to the colonial power are finally severed. While this developmental trajectory is well documented in many of the case studies discussed in, and since, Schneider (2007), a comparison of Hong Kong and Gibraltar shows, in certain cases, that association with Britain can be seen as the best guarantor of these local identities and varieties of English. The present article sketches this alternate developmental trajectory, and examines under what circumstances it may emerge and how widely it might be applied. 相似文献