Estimating the parameters of the linear compartment model

In this paper we consider the linear compartment model and consider the estimation procedures of the different parameters. We discuss a method to obtain the initial estimators, which can be used for any iterative procedures to obtain the least-squares estimators. Four different types of confidence intervals have been discussed and they have been compared by computer simulations. We propose different methods to estimate the number of components of the linear compartment model. One data set has been used to see how the different methods work in practice.     

Modified Sarhan–Balakrishnan singular bivariate distribution

Recently Sarhan and Balakrishnan [2007. A new class of bivariate distribution and its mixture. Journal of Multivariate Analysis 98, 1508–1527] introduced a new bivariate distribution using generalized exponential and exponential distributions. They discussed several interesting properties of this new distribution. Unfortunately, they did not discuss any estimation procedure of the unknown parameters. In this paper using the similar idea as of Sarhan and Balakrishnan [2007. A new class of bivariate distribution and its mixture. Journal of Multivariate Analysis 98, 1508–1527], we have proposed a singular bivariate distribution, which has an extra shape parameter. It is observed that the marginal distributions of the proposed bivariate distribution are more flexible than the corresponding marginal distributions of the Marshall–Olkin bivariate exponential distribution, Sarhan–Balakrishnan's bivariate distribution or the bivariate generalized exponential distribution. Different properties of this new distribution have been discussed. We provide the maximum likelihood estimators of the unknown parameters using EM algorithm. We reported some simulation results and performed two data analysis for illustrative purposes. Finally we propose some generalizations of this bivariate model.     

Time truncated acceptance sampling plans for generalized exponential distribution

Acceptance sampling plans for generalized exponential distribution when the lifetime experiment is truncated at a pre-determined time are provided in this article. The tables are provided for the minimum sample size required to ensure a certain median life of the experimental unit when the shape parameter is two. The operating characteristic function values of the sampling plans and the associated producer's risks are also presented. It is shown that the tables presented here can be used if instead of median life, other percentile life is chosen as the criterion or if the shape parameter is not two. Examples are provided for illustrative purposes.     

A class of absolutely continuous bivariate distributions

Block and Basu bivariate exponential distribution is one of the most popular absolutely continuous bivariate distributions. Extensive work has been done on the Block and Basu bivariate exponential model over the past several decades. Interestingly it is observed that the Block and Basu bivariate exponential model can be extended to the Weibull model also. We call this new model as the Block and Basu bivariate Weibull model. We consider different properties of the Block and Basu bivariate Weibull model. The Block and Basu bivariate Weibull model has four unknown parameters and the maximum likelihood estimators cannot be obtained in closed form. To compute the maximum likelihood estimators directly, one needs to solve a four dimensional optimization problem. We propose to use the EM algorithm for computing the maximum likelihood estimators of the unknown parameters. The proposed EM algorithm can be carried out by solving one non-linear equation at each EM step. Our method can be also used to compute the maximum likelihood estimators for the Block and Basu bivariate exponential model. One data analysis has been preformed for illustrative purpose.     

Chernoff distance for doubly truncated distributions

In a recent paper, Nair et al. [Stat Pap 52:893–909, 2011] proposed Chernoff distance measure for left/right-truncated random variables and studied their properties in the context of reliability analysis. Here we extend the definition of Chernoff distance for doubly truncated distributions. This measure may help the information theorists and reliability analysts to study the various characteristics of a system/component when it fails between two time points. We study some properties of this measure and obtain its upper and lower bounds. We also study the interval Chernoff distance between the original and weighted distributions. These results generalize and enhance the related existing results that are developed based on Chernoff distance for one-sided truncated random variables.     

Nonparametric estimation of the number of components of a superposition of renewal processes

Suppose all events occurring in an unknown number (ν)$(\nu )$ of iid renewal processes, with a common renewal distribution F  , are observed for a fixed time τ$\tau$, where both ν$\nu$ and F   are unknown. The individual processes are not known a priori, but for each event, the process that generated it is identified. For example, in software reliability application, the errors (or bugs) in a piece of software are not known a priori, but whenever the software fails, the error causing the failure is identified. We present a nonparametric method for estimating ν$\nu$ and investigate its properties. Our results show that the proposed estimator performs well in terms of bias and asymptotic normality, while the MLE of ν$\nu$ derived assuming that the common renewal distribution is exponential may be seriously biased if that assumption does not hold.     

Stress-strength reliability estimation for exponentially distributed system with common minimum guarantee time

Abstract

In this article, we study the problem of estimating the stress-strength reliability, where the stress and strength variables follow independent exponential distributions with a common location parameter but different scale parameters. All parameters are assumed to be unknown. We derive the MLE, the UMVUE of the reliability parameter. We also derive the Bayes estimators considering conjugate prior distributions for the scale parameters and a dependent prior for the common location parameter. Monte Carlo simulations have been carried out to compare among the proposed estimators with respect to different loss functions.     

Tolerance intervals for exponentiated scale family of distributions

In this article we provide an asymptotic upper β-expectation and β-content γ-level tolerance intervals for a new family of distributions, namely the Exponentiated Scale family of distributions. Expected coverage of a proposed β-expectation Tolerance Interval is obtained. Bootstrap-based tolerance limits are obtained for data arising from an exponentiated exponential distribution.     

Some practical considerations in three‐arm non‐inferiority trial design

Non‐inferiority trials aim to demonstrate whether an experimental therapy is not unacceptably worse than an active reference therapy already in use. When applicable, a three‐arm non‐inferiority trial, including an experiment therapy, an active reference therapy, and a placebo, is often recommended to assess assay sensitivity and internal validity of a trial. In this paper, we share some practical considerations based on our experience from a phase III three‐arm non‐inferiority trial. First, we discuss the determination of the total sample size and its optimal allocation based on the overall power of the non‐inferiority testing procedure and provide ready‐to‐use R code for implementation. Second, we consider the non‐inferiority goal of ‘capturing all possibilities’ and show that it naturally corresponds to a simple two‐step testing procedure. Finally, using this two‐step non‐inferiority testing procedure as an example, we compare extensively commonly used frequentist p ‐value methods with the Bayesian posterior probability approach. Copyright © 2016 John Wiley & Sons, Ltd.     

Nonparametric estimation of time-to-event distribution based on recall data in observational studies

In a cross-sectional observational study, time-to-event distribution can be estimated from data on current status or from recalled data on the time of occurrence. In either case, one can treat the data as having been interval censored, and use the nonparametric maximum likelihood estimator proposed by Turnbull (J R Stat Soc Ser B 38:290–295, 1976). However, the chance of recall may depend on the time span between the occurrence of the event and the time of interview. In such a case, the underlying censoring would be informative, rendering the Turnbull estimator inappropriate. In this article, we provide a nonparametric maximum likelihood estimator of the distribution of interest, by using a model adapted to the special nature of the data at hand. We also provide a computationally simple approximation of this estimator, and establish the consistency of both the original and the approximate versions, under mild conditions. Monte Carlo simulations indicate that the proposed estimators have smaller bias than the Turnbull estimator based on incomplete recall data, smaller variance than the Turnbull estimator based on current status data, and smaller mean squared error than both of them. The method is applied to menarcheal data from a recent Anthropometric study of adolescent and young adult females in Kolkata, India.