A structured framework for assessing sensitivity to missing data assumptions in longitudinal clinical trials

The objective of this research was to demonstrate a framework for drawing inference from sensitivity analyses of incomplete longitudinal clinical trial data via a re‐analysis of data from a confirmatory clinical trial in depression. A likelihood‐based approach that assumed missing at random (MAR) was the primary analysis. Robustness to departure from MAR was assessed by comparing the primary result to those from a series of analyses that employed varying missing not at random (MNAR) assumptions (selection models, pattern mixture models and shared parameter models) and to MAR methods that used inclusive models. The key sensitivity analysis used multiple imputation assuming that after dropout the trajectory of drug‐treated patients was that of placebo treated patients with a similar outcome history (placebo multiple imputation). This result was used as the worst reasonable case to define the lower limit of plausible values for the treatment contrast. The endpoint contrast from the primary analysis was ? 2.79 (p = .013). In placebo multiple imputation, the result was ? 2.17. Results from the other sensitivity analyses ranged from ? 2.21 to ? 3.87 and were symmetrically distributed around the primary result. Hence, no clear evidence of bias from missing not at random data was found. In the worst reasonable case scenario, the treatment effect was 80% of the magnitude of the primary result. Therefore, it was concluded that a treatment effect existed. The structured sensitivity framework of using a worst reasonable case result based on a controlled imputation approach with transparent and debatable assumptions supplemented a series of plausible alternative models under varying assumptions was useful in this specific situation and holds promise as a generally useful framework. Copyright © 2012 John Wiley & Sons, Ltd.     

A course in constructing effective displays of data for pharmaceutical research personnel

Interpreting data and communicating effectively through graphs and tables are requisite skills for statisticians and non‐statisticians in the pharmaceutical industry. However, the quality of visual displays of data in the medical and pharmaceutical literature and at scientific conferences is severely lacking. We describe an interactive, workshop‐driven, 2‐day short course that we constructed for pharmaceutical research personnel to learn these skills. The examples in the course and the workshop datasets source from our professional experiences, the scientific literature, and the mass media. During the course, the participants are exposed to and gain hands‐on experience with the principles of visual and graphical perception, design, and construction of both graphic and tabular displays of quantitative and qualitative information. After completing the course, with a critical eye, the participants are able to construct, revise, critique, and interpret graphic and tabular displays according to an extensive set of guidelines. Copyright © 2013 John Wiley & Sons, Ltd.     

Two Pitfalls of Using Standard Regression Diagnostics When Both X and Y Have Measurement Error

Modern exploratory data analysis produces models that are not based on physical theory but that are consistent with pictures of the data. When both X and Y have error this can be risky, because important features are hidden. Two examples are given that show that systematic model departures and heteroscedasticity may not be detectable with standard regression diagnostics.     

Correlation Coefficient Revisited

Elementary approaches to prove basic properties of the correlation coefficient are of pedagogical interest. Besides posing another proof, this article gives variations of the proofs already existing in the statistical literature     

An Improved Boxplot for Univariate Data

The boxplot is an effective data-visualization tool useful in diverse applications and disciplines. Although more sophisticated graphical methods exist, the boxplot remains relevant due to its simplicity, interpretability, and usefulness, even in the age of big data. This article highlights the origins and developments of the boxplot that is now widely viewed as an industry standard as well as its inherent limitations when dealing with data from skewed distributions, particularly when detecting outliers. The proposed Ratio-Skewed boxplot is shown to be practical and suitable for outlier labeling across several parametric distributions.     

Culinary Magazines

Abstract

Marvel Comics, along with rival DC Comics, is one of the two powerhouses of the comic book industry and has been for many decades. The company was founded in 1939 by pulp magazine publisher Martin Goodman. Goodman owned various publishing houses responsible for a variety of pulp titles, including Marvel Science Stories. In 1939, a colleague persuaded Goodman that comic books were the upcoming trend in periodical publishing, so Good-man launched a book called Marvel Comics. Issue no. 1 contained a story by Bill Everett about the Sub-Mariner, as well as the first appearance of the Human Torch. Both characters quickly became leading draws of the Golden Age of comics. Soon after, Goodman hired writer Joe Simon and artist Jack Kirby, who were to become giants in the industry. Simon and Kirby created Captain America, a character who remains a comics icon even today. In those early days, Goodman also hired another future legend: writer Stan Lee, who happened to be Good-man's nephew.

Goodman's comic company was known officially as Timely Comics, Inc., then later as Atlas Publishing. The firm did not change its name to Marvel until the early 1960s. Timely benefitted from the comics boom of the early 1940s, but interest in super-hero stories waned later in the decade. Atlas briefly revived its super-hero line-up in 1954, but the company spent most of the next decade publishing romance, western, horror, and humor comics.1 1. Les Daniels, Marvel: Five Decades of the World's Greatest Comics (NY: Abrams, 1991), pp. 17–23, 26–36, 40–61.¹     

Data-dependent probability matching priors of the second order

In this paper, we consider the preliminary test approach for the estimation of the regression parameter in a multiple regression model under a multicollinearity situation. The preliminary test two-parameter estimators based on the Wald (W), likelihood ratio, and Lagrangian multiplier tests are given, when it is suspected that the regression parameter may be restricted to a subspace and the regression error is distributed with multivariate Student's t distribution. The bias and mean square error of the proposed estimators are derived and compared. The conditions of superiority of the proposed estimators are obtained. Finally, we conclude that the optimum choice of the level of significance becomes the traditional choice by using the Wald test.     

Probability matching priors for two-sided tolerance intervals in balanced one-way and two-way nested random effects models

We consider two-sided Bayesian tolerance intervals, with approximate frequentist validity, for a future observation in balanced one-way and two-way nested random effects models. Probability matching conditions, specific to this problem, are derived in either case via a technique that involves inversion of approximate posterior characteristic functions. In addition to yielding probability matching priors for the present problem, these conditions are useful in evaluating certain other priors that have received attention in the literature.     

Parameter estimation in nonlinear regression models 1

Fisher information contained in record values, inter-record times and their concomitants from a sample of fixed size is derived in general and explicit expressions are deduced for some specific known bivariate classes of distributions. A comparison between fixed sampling and inverse sampling schemes with equal number of records and concomitants is also carried out. We also consider parameter estimation based on bivariate records and a small simulation study is done.     

Book reviews

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